Abstract
Objective: Quantify the enhancement of parkinsonian rigidity associated with a contralateral activation maneuver. Methods: Twelve subjects with PD and eight controls participated in the study protocol. Subjects' tested hand was displaced by a servo-motor throughout wrist flexion and extension motions of 60° without and with a concurrent gripping activation in the contralateral hand, referred to as Passive and Active conditions, respectively. Subjects with PD were tested in both OFF-MED and ON-MED states. Rigidity was quantified by integrating torque with position during both flexion and extension (torque resistance). ANOVA was performed to assess the effect of contralateral activation on rigidity. Results: PD patients had significantly (0.038) enhanced torque resistance in OFF-MED compared to healthy controls and ON-MED. In the Active condition, differences in torque resistance were magnified (p= 0.002). Medication substantially reduced differences in torque resistance between controls and PD patients in the Passive and Active conditions. Conclusions: A contralateral activation maneuver substantially increases rigidity in patients with PD, specifically the OFF-MED state. Rigidity is reduced with the application of dopaminergic medication, even with the presence of a contralateral activation maneuver. Significance: These data support the use of a contralateral activation maneuver as a tool in the diagnosis of PD.
| Original language | English |
|---|---|
| Pages (from-to) | 1595-1601 |
| Number of pages | 7 |
| Journal | Clinical Neurophysiology |
| Volume | 122 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2011 |
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All Science Journal Classification (ASJC) codes
- Clinical Neurology
- Neurology
- Physiology (medical)
- Sensory Systems
Cite this
Enhancement of parkinsonian rigidity with contralateral hand activation. / Powell, Douglas; Hanson, Nicholas; Threlkeld, Joseph; Fang, Xiang; Xia, Ruiping.
In: Clinical Neurophysiology, Vol. 122, No. 8, 08.2011, p. 1595-1601.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Enhancement of parkinsonian rigidity with contralateral hand activation
AU - Powell, Douglas
AU - Hanson, Nicholas
AU - Threlkeld, Joseph
AU - Fang, Xiang
AU - Xia, Ruiping
PY - 2011/8
Y1 - 2011/8
N2 - Objective: Quantify the enhancement of parkinsonian rigidity associated with a contralateral activation maneuver. Methods: Twelve subjects with PD and eight controls participated in the study protocol. Subjects' tested hand was displaced by a servo-motor throughout wrist flexion and extension motions of 60° without and with a concurrent gripping activation in the contralateral hand, referred to as Passive and Active conditions, respectively. Subjects with PD were tested in both OFF-MED and ON-MED states. Rigidity was quantified by integrating torque with position during both flexion and extension (torque resistance). ANOVA was performed to assess the effect of contralateral activation on rigidity. Results: PD patients had significantly (0.038) enhanced torque resistance in OFF-MED compared to healthy controls and ON-MED. In the Active condition, differences in torque resistance were magnified (p= 0.002). Medication substantially reduced differences in torque resistance between controls and PD patients in the Passive and Active conditions. Conclusions: A contralateral activation maneuver substantially increases rigidity in patients with PD, specifically the OFF-MED state. Rigidity is reduced with the application of dopaminergic medication, even with the presence of a contralateral activation maneuver. Significance: These data support the use of a contralateral activation maneuver as a tool in the diagnosis of PD.
AB - Objective: Quantify the enhancement of parkinsonian rigidity associated with a contralateral activation maneuver. Methods: Twelve subjects with PD and eight controls participated in the study protocol. Subjects' tested hand was displaced by a servo-motor throughout wrist flexion and extension motions of 60° without and with a concurrent gripping activation in the contralateral hand, referred to as Passive and Active conditions, respectively. Subjects with PD were tested in both OFF-MED and ON-MED states. Rigidity was quantified by integrating torque with position during both flexion and extension (torque resistance). ANOVA was performed to assess the effect of contralateral activation on rigidity. Results: PD patients had significantly (0.038) enhanced torque resistance in OFF-MED compared to healthy controls and ON-MED. In the Active condition, differences in torque resistance were magnified (p= 0.002). Medication substantially reduced differences in torque resistance between controls and PD patients in the Passive and Active conditions. Conclusions: A contralateral activation maneuver substantially increases rigidity in patients with PD, specifically the OFF-MED state. Rigidity is reduced with the application of dopaminergic medication, even with the presence of a contralateral activation maneuver. Significance: These data support the use of a contralateral activation maneuver as a tool in the diagnosis of PD.
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U2 - 10.1016/j.clinph.2011.01.010
DO - 10.1016/j.clinph.2011.01.010
M3 - Article
C2 - 21330199
AN - SCOPUS:79960242074
VL - 122
SP - 1595
EP - 1601
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 8
ER -