Enhancement of parkinsonian rigidity with contralateral hand activation

Douglas Powell, Nicholas Hanson, Joseph Threlkeld, Xiang Fang, Ruiping Xia

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: Quantify the enhancement of parkinsonian rigidity associated with a contralateral activation maneuver. Methods: Twelve subjects with PD and eight controls participated in the study protocol. Subjects' tested hand was displaced by a servo-motor throughout wrist flexion and extension motions of 60° without and with a concurrent gripping activation in the contralateral hand, referred to as Passive and Active conditions, respectively. Subjects with PD were tested in both OFF-MED and ON-MED states. Rigidity was quantified by integrating torque with position during both flexion and extension (torque resistance). ANOVA was performed to assess the effect of contralateral activation on rigidity. Results: PD patients had significantly (0.038) enhanced torque resistance in OFF-MED compared to healthy controls and ON-MED. In the Active condition, differences in torque resistance were magnified (p= 0.002). Medication substantially reduced differences in torque resistance between controls and PD patients in the Passive and Active conditions. Conclusions: A contralateral activation maneuver substantially increases rigidity in patients with PD, specifically the OFF-MED state. Rigidity is reduced with the application of dopaminergic medication, even with the presence of a contralateral activation maneuver. Significance: These data support the use of a contralateral activation maneuver as a tool in the diagnosis of PD.

Original languageEnglish
Pages (from-to)1595-1601
Number of pages7
JournalClinical Neurophysiology
Volume122
Issue number8
DOIs
StatePublished - Aug 2011

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Torque
Hand
Wrist
Analysis of Variance

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

Cite this

Enhancement of parkinsonian rigidity with contralateral hand activation. / Powell, Douglas; Hanson, Nicholas; Threlkeld, Joseph; Fang, Xiang; Xia, Ruiping.

In: Clinical Neurophysiology, Vol. 122, No. 8, 08.2011, p. 1595-1601.

Research output: Contribution to journalArticle

Powell, Douglas ; Hanson, Nicholas ; Threlkeld, Joseph ; Fang, Xiang ; Xia, Ruiping. / Enhancement of parkinsonian rigidity with contralateral hand activation. In: Clinical Neurophysiology. 2011 ; Vol. 122, No. 8. pp. 1595-1601.
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