Eosinophil accumulation and activation in antigen-induced late asthmatic response in Guinea pigs

Haruhito Sugiyama, Ryosuke Eda, Chiharu Okada, Russell J. Hopp, Againdra K. Bewtra, Robert G. Townley

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The purpose of this study was to investigate the participation of airway eosinophils in the antigen-induced late asthmatic response (LAR) and increased airway responsiveness in the guinea pig model of asthma. After antigen challenge, guinea pigs sensitized with aerosolized ovalbumin showed a late-phase decrease in specific airway conductance, which was accompanied by airway hyperresponsiveness to histamine, eosinophilia in the bronchoalveolar lavage fluid (BALF), decreased BALF eosinophil density, and increased generation of superoxide anions from purified BALF eosinophils. We demonstrated an association of the LAR with eosinophil accumulation and activation in the airway.

Original languageEnglish (US)
Pages (from-to)37-45
Number of pages9
JournalJournal of Asthma
Volume32
Issue number1
DOIs
StatePublished - Jan 1 1995

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

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    Sugiyama, H., Eda, R., Okada, C., Hopp, R. J., Bewtra, A. K., & Townley, R. G. (1995). Eosinophil accumulation and activation in antigen-induced late asthmatic response in Guinea pigs. Journal of Asthma, 32(1), 37-45. https://doi.org/10.3109/02770909509089498