Eosinophil accumulation and activation in antigen-induced late asthmatic response in Guinea pigs

Haruhito Sugiyama, Ryosuke Eda, Chiharu Okada, Russell J. Hopp, Againdra K. Bewtra, Robert G. Townley

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The purpose of this study was to investigate the participation of airway eosinophils in the antigen-induced late asthmatic response (LAR) and increased airway responsiveness in the guinea pig model of asthma. After antigen challenge, guinea pigs sensitized with aerosolized ovalbumin showed a late-phase decrease in specific airway conductance, which was accompanied by airway hyperresponsiveness to histamine, eosinophilia in the bronchoalveolar lavage fluid (BALF), decreased BALF eosinophil density, and increased generation of superoxide anions from purified BALF eosinophils. We demonstrated an association of the LAR with eosinophil accumulation and activation in the airway.

Original languageEnglish
Pages (from-to)37-45
Number of pages9
JournalJournal of Asthma
Volume32
Issue number1
DOIs
StatePublished - 1995

Fingerprint

Eosinophils
Bronchoalveolar Lavage Fluid
Guinea Pigs
Antigens
Ovalbumin
Eosinophilia
Superoxides
Histamine
Asthma

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health

Cite this

Eosinophil accumulation and activation in antigen-induced late asthmatic response in Guinea pigs. / Sugiyama, Haruhito; Eda, Ryosuke; Okada, Chiharu; Hopp, Russell J.; Bewtra, Againdra K.; Townley, Robert G.

In: Journal of Asthma, Vol. 32, No. 1, 1995, p. 37-45.

Research output: Contribution to journalArticle

Sugiyama, Haruhito ; Eda, Ryosuke ; Okada, Chiharu ; Hopp, Russell J. ; Bewtra, Againdra K. ; Townley, Robert G. / Eosinophil accumulation and activation in antigen-induced late asthmatic response in Guinea pigs. In: Journal of Asthma. 1995 ; Vol. 32, No. 1. pp. 37-45.
@article{e68f36c5469045f790fb2cae36a50d18,
title = "Eosinophil accumulation and activation in antigen-induced late asthmatic response in Guinea pigs",
abstract = "The purpose of this study was to investigate the participation of airway eosinophils in the antigen-induced late asthmatic response (LAR) and increased airway responsiveness in the guinea pig model of asthma. After antigen challenge, guinea pigs sensitized with aerosolized ovalbumin showed a late-phase decrease in specific airway conductance, which was accompanied by airway hyperresponsiveness to histamine, eosinophilia in the bronchoalveolar lavage fluid (BALF), decreased BALF eosinophil density, and increased generation of superoxide anions from purified BALF eosinophils. We demonstrated an association of the LAR with eosinophil accumulation and activation in the airway.",
author = "Haruhito Sugiyama and Ryosuke Eda and Chiharu Okada and Hopp, {Russell J.} and Bewtra, {Againdra K.} and Townley, {Robert G.}",
year = "1995",
doi = "10.3109/02770909509089498",
language = "English",
volume = "32",
pages = "37--45",
journal = "Journal of Asthma",
issn = "0277-0903",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Eosinophil accumulation and activation in antigen-induced late asthmatic response in Guinea pigs

AU - Sugiyama, Haruhito

AU - Eda, Ryosuke

AU - Okada, Chiharu

AU - Hopp, Russell J.

AU - Bewtra, Againdra K.

AU - Townley, Robert G.

PY - 1995

Y1 - 1995

N2 - The purpose of this study was to investigate the participation of airway eosinophils in the antigen-induced late asthmatic response (LAR) and increased airway responsiveness in the guinea pig model of asthma. After antigen challenge, guinea pigs sensitized with aerosolized ovalbumin showed a late-phase decrease in specific airway conductance, which was accompanied by airway hyperresponsiveness to histamine, eosinophilia in the bronchoalveolar lavage fluid (BALF), decreased BALF eosinophil density, and increased generation of superoxide anions from purified BALF eosinophils. We demonstrated an association of the LAR with eosinophil accumulation and activation in the airway.

AB - The purpose of this study was to investigate the participation of airway eosinophils in the antigen-induced late asthmatic response (LAR) and increased airway responsiveness in the guinea pig model of asthma. After antigen challenge, guinea pigs sensitized with aerosolized ovalbumin showed a late-phase decrease in specific airway conductance, which was accompanied by airway hyperresponsiveness to histamine, eosinophilia in the bronchoalveolar lavage fluid (BALF), decreased BALF eosinophil density, and increased generation of superoxide anions from purified BALF eosinophils. We demonstrated an association of the LAR with eosinophil accumulation and activation in the airway.

UR - http://www.scopus.com/inward/record.url?scp=0028932278&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028932278&partnerID=8YFLogxK

U2 - 10.3109/02770909509089498

DO - 10.3109/02770909509089498

M3 - Article

VL - 32

SP - 37

EP - 45

JO - Journal of Asthma

JF - Journal of Asthma

SN - 0277-0903

IS - 1

ER -