Epidemiologic characteristics of the flat adenoma of muto - A prospective study

Stephen J. Lanspa, J. Rouse, T. Smyrk, P. Watson, J. X. Jenkins, Henry T. Lynch

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

The flat adenoma is an endoscopically visible lesion that histologically consists of adenomatous change near the luminal surface of colonic tubules. We have described three families with hereditary colon cancer with later age of onset than familial adenomatous polyposis (FAP) and with multiple proximal colonic flat adenomas. These families have been linked to the FAP locus on chromosome 5. Our aim was to determine whether the flat adenoma is pathognomonic of this hereditary flat adenoma syndrome (HFAS) or merely an atypical or early tubular adenoma with occurrence in patients other than those from colon cancer-prone families. Methods: We prospectively examined a population referred for colonoscopy within a one-year period. During colonoscopy, flat adenomas were specifically sought and all lesions were removed endoscopically and evaluated histologically. Members of known hereditary colon cancer families were excluded. Results: One hundred forty-eight patients underwent colonoscopy (64 men and 84 women). Median age was 61 years. Fifty-seven patients had 157 polyps. One hundred thirty-six polyps were reviewed histologically. Thirty-five (23.6 percent) of the referred patients had adenomas, of whom twelve patients had only flat adenomas while six had both flat and other adenomas (18=12 percent of 148). The associations between flat adenoma occurrence and various predictors (sex, race, prior colonic neoplasms, family history of cancer, synchronous adenomas) were similar to those seen with other adenomas. Flat adenomas were found in nearly equal proportions of patients under or over age 61 years (11 percent and 13 percent, respectively). Other adenomas were significantly more common in the older group (6 percentvs. 25 percent;P

Original languageEnglish
Pages (from-to)543-546
Number of pages4
JournalDiseases of the Colon and Rectum
Volume35
Issue number6
DOIs
StatePublished - Jun 1992

Fingerprint

Adenoma
Prospective Studies
Colonic Neoplasms
Colonoscopy
Adenomatous Polyposis Coli
Polyps
Chromosomes, Human, Pair 5
Age of Onset

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Epidemiologic characteristics of the flat adenoma of muto - A prospective study. / Lanspa, Stephen J.; Rouse, J.; Smyrk, T.; Watson, P.; Jenkins, J. X.; Lynch, Henry T.

In: Diseases of the Colon and Rectum, Vol. 35, No. 6, 06.1992, p. 543-546.

Research output: Contribution to journalArticle

Lanspa, Stephen J. ; Rouse, J. ; Smyrk, T. ; Watson, P. ; Jenkins, J. X. ; Lynch, Henry T. / Epidemiologic characteristics of the flat adenoma of muto - A prospective study. In: Diseases of the Colon and Rectum. 1992 ; Vol. 35, No. 6. pp. 543-546.
@article{6bfec98947b84b65ba986350e12eeb88,
title = "Epidemiologic characteristics of the flat adenoma of muto - A prospective study",
abstract = "The flat adenoma is an endoscopically visible lesion that histologically consists of adenomatous change near the luminal surface of colonic tubules. We have described three families with hereditary colon cancer with later age of onset than familial adenomatous polyposis (FAP) and with multiple proximal colonic flat adenomas. These families have been linked to the FAP locus on chromosome 5. Our aim was to determine whether the flat adenoma is pathognomonic of this hereditary flat adenoma syndrome (HFAS) or merely an atypical or early tubular adenoma with occurrence in patients other than those from colon cancer-prone families. Methods: We prospectively examined a population referred for colonoscopy within a one-year period. During colonoscopy, flat adenomas were specifically sought and all lesions were removed endoscopically and evaluated histologically. Members of known hereditary colon cancer families were excluded. Results: One hundred forty-eight patients underwent colonoscopy (64 men and 84 women). Median age was 61 years. Fifty-seven patients had 157 polyps. One hundred thirty-six polyps were reviewed histologically. Thirty-five (23.6 percent) of the referred patients had adenomas, of whom twelve patients had only flat adenomas while six had both flat and other adenomas (18=12 percent of 148). The associations between flat adenoma occurrence and various predictors (sex, race, prior colonic neoplasms, family history of cancer, synchronous adenomas) were similar to those seen with other adenomas. Flat adenomas were found in nearly equal proportions of patients under or over age 61 years (11 percent and 13 percent, respectively). Other adenomas were significantly more common in the older group (6 percentvs. 25 percent;P",
author = "Lanspa, {Stephen J.} and J. Rouse and T. Smyrk and P. Watson and Jenkins, {J. X.} and Lynch, {Henry T.}",
year = "1992",
month = "6",
doi = "10.1007/BF02050533",
language = "English",
volume = "35",
pages = "543--546",
journal = "Diseases of the Colon and Rectum",
issn = "0012-3706",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Epidemiologic characteristics of the flat adenoma of muto - A prospective study

AU - Lanspa, Stephen J.

AU - Rouse, J.

AU - Smyrk, T.

AU - Watson, P.

AU - Jenkins, J. X.

AU - Lynch, Henry T.

PY - 1992/6

Y1 - 1992/6

N2 - The flat adenoma is an endoscopically visible lesion that histologically consists of adenomatous change near the luminal surface of colonic tubules. We have described three families with hereditary colon cancer with later age of onset than familial adenomatous polyposis (FAP) and with multiple proximal colonic flat adenomas. These families have been linked to the FAP locus on chromosome 5. Our aim was to determine whether the flat adenoma is pathognomonic of this hereditary flat adenoma syndrome (HFAS) or merely an atypical or early tubular adenoma with occurrence in patients other than those from colon cancer-prone families. Methods: We prospectively examined a population referred for colonoscopy within a one-year period. During colonoscopy, flat adenomas were specifically sought and all lesions were removed endoscopically and evaluated histologically. Members of known hereditary colon cancer families were excluded. Results: One hundred forty-eight patients underwent colonoscopy (64 men and 84 women). Median age was 61 years. Fifty-seven patients had 157 polyps. One hundred thirty-six polyps were reviewed histologically. Thirty-five (23.6 percent) of the referred patients had adenomas, of whom twelve patients had only flat adenomas while six had both flat and other adenomas (18=12 percent of 148). The associations between flat adenoma occurrence and various predictors (sex, race, prior colonic neoplasms, family history of cancer, synchronous adenomas) were similar to those seen with other adenomas. Flat adenomas were found in nearly equal proportions of patients under or over age 61 years (11 percent and 13 percent, respectively). Other adenomas were significantly more common in the older group (6 percentvs. 25 percent;P

AB - The flat adenoma is an endoscopically visible lesion that histologically consists of adenomatous change near the luminal surface of colonic tubules. We have described three families with hereditary colon cancer with later age of onset than familial adenomatous polyposis (FAP) and with multiple proximal colonic flat adenomas. These families have been linked to the FAP locus on chromosome 5. Our aim was to determine whether the flat adenoma is pathognomonic of this hereditary flat adenoma syndrome (HFAS) or merely an atypical or early tubular adenoma with occurrence in patients other than those from colon cancer-prone families. Methods: We prospectively examined a population referred for colonoscopy within a one-year period. During colonoscopy, flat adenomas were specifically sought and all lesions were removed endoscopically and evaluated histologically. Members of known hereditary colon cancer families were excluded. Results: One hundred forty-eight patients underwent colonoscopy (64 men and 84 women). Median age was 61 years. Fifty-seven patients had 157 polyps. One hundred thirty-six polyps were reviewed histologically. Thirty-five (23.6 percent) of the referred patients had adenomas, of whom twelve patients had only flat adenomas while six had both flat and other adenomas (18=12 percent of 148). The associations between flat adenoma occurrence and various predictors (sex, race, prior colonic neoplasms, family history of cancer, synchronous adenomas) were similar to those seen with other adenomas. Flat adenomas were found in nearly equal proportions of patients under or over age 61 years (11 percent and 13 percent, respectively). Other adenomas were significantly more common in the older group (6 percentvs. 25 percent;P

UR - http://www.scopus.com/inward/record.url?scp=0026762432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026762432&partnerID=8YFLogxK

U2 - 10.1007/BF02050533

DO - 10.1007/BF02050533

M3 - Article

VL - 35

SP - 543

EP - 546

JO - Diseases of the Colon and Rectum

JF - Diseases of the Colon and Rectum

SN - 0012-3706

IS - 6

ER -