Abstract
Cancer of the colon and rectum is extremely common in the Western hemisphere. The etiopathogenesis of colorectal cancer is an intertwined play of several genetic and environmental factors to which an individual is exposed to during the lifetime. The predominance of one factor over another decides the timing of development of this cancer with respect to the individual’s age. Familial syndromes like Lynch syndrome and familial adenomatous polyposis predispose an individual to cancer early in their lifespan since they carry the genetic mutation. A sporadic cancer, on the other hand, follows a very interesting and often predictable path from a polyp to carcinoma. There are three such pathways which the colonic epithelium may undertake toward the development of cancer. Each of the pathways has its own unique set of genotypic and phenotypic expression which needs to be understood well to accomplish our ultimate goal for prevention of colorectal cancer.
| Original language | English (US) |
|---|---|
| Title of host publication | Surgical Techniques in Rectal Cancer |
| Subtitle of host publication | Transanal, Laparoscopic and Robotic Approach |
| Publisher | Springer Japan |
| Pages | 19-35 |
| Number of pages | 17 |
| ISBN (Electronic) | 9784431555797 |
| ISBN (Print) | 9784431555780 |
| DOIs | |
| State | Published - Jan 1 2018 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
Cite this
Epidemiology and carcinogenesis of rectal cancer. / Bikhchandani, Jai; Thorson, Alan G.; Lynch, Henry T.
Surgical Techniques in Rectal Cancer: Transanal, Laparoscopic and Robotic Approach. Springer Japan, 2018. p. 19-35.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Epidemiology and carcinogenesis of rectal cancer
AU - Bikhchandani, Jai
AU - Thorson, Alan G.
AU - Lynch, Henry T.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Cancer of the colon and rectum is extremely common in the Western hemisphere. The etiopathogenesis of colorectal cancer is an intertwined play of several genetic and environmental factors to which an individual is exposed to during the lifetime. The predominance of one factor over another decides the timing of development of this cancer with respect to the individual’s age. Familial syndromes like Lynch syndrome and familial adenomatous polyposis predispose an individual to cancer early in their lifespan since they carry the genetic mutation. A sporadic cancer, on the other hand, follows a very interesting and often predictable path from a polyp to carcinoma. There are three such pathways which the colonic epithelium may undertake toward the development of cancer. Each of the pathways has its own unique set of genotypic and phenotypic expression which needs to be understood well to accomplish our ultimate goal for prevention of colorectal cancer.
AB - Cancer of the colon and rectum is extremely common in the Western hemisphere. The etiopathogenesis of colorectal cancer is an intertwined play of several genetic and environmental factors to which an individual is exposed to during the lifetime. The predominance of one factor over another decides the timing of development of this cancer with respect to the individual’s age. Familial syndromes like Lynch syndrome and familial adenomatous polyposis predispose an individual to cancer early in their lifespan since they carry the genetic mutation. A sporadic cancer, on the other hand, follows a very interesting and often predictable path from a polyp to carcinoma. There are three such pathways which the colonic epithelium may undertake toward the development of cancer. Each of the pathways has its own unique set of genotypic and phenotypic expression which needs to be understood well to accomplish our ultimate goal for prevention of colorectal cancer.
UR - http://www.scopus.com/inward/record.url?scp=85046413238&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85046413238&partnerID=8YFLogxK
U2 - 10.1007/978-4-431-55579-7_2
DO - 10.1007/978-4-431-55579-7_2
M3 - Chapter
AN - SCOPUS:85046413238
SN - 9784431555780
SP - 19
EP - 35
BT - Surgical Techniques in Rectal Cancer
PB - Springer Japan
ER -