Abstract
Leukemia/lymphoma related factor/POK erythroid myeloid ontogenic factor (LRF/Pokemon) is a member of the POK family of proteins that promotes oncogenesis in several forms of cancer. Recently, we found higher LRF expression in human breast and prostate carcinomas compared to the corresponding normal tissues. The aim of this study was to examine the regulation of LRF expression in human prostate cells. Epidermal growth factor (EGF) and its receptors mediate several tumorigenic cascades that regulate cell differentiation, proliferation, migration and survival of prostate cancer cells. There was significantly higher level of LRF expression in the nucleus of LNCaP and PC-3 cells than RWPE-1 cells. A significant increase in LRF expression was observed with increasing doses of EGF in more aggressive and androgen-sensitive prostate cancer cells suggesting that EGF signaling pathway is critical in upregulating the expression of LRF/Pokemon to promote oncogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 496-501 |
| Number of pages | 6 |
| Journal | Experimental and Molecular Pathology |
| Volume | 91 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 2011 |
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All Science Journal Classification (ASJC) codes
- Clinical Biochemistry
- Molecular Biology
- Pathology and Forensic Medicine
Cite this
Epidermal growth factor increases LRF/Pokemon expression in human prostate cancer cells. / Aggarwal, Himanshu; Aggarwal, Anshu; Agrawal, Devendra K.
In: Experimental and Molecular Pathology, Vol. 91, No. 2, 10.2011, p. 496-501.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Epidermal growth factor increases LRF/Pokemon expression in human prostate cancer cells
AU - Aggarwal, Himanshu
AU - Aggarwal, Anshu
AU - Agrawal, Devendra K.
PY - 2011/10
Y1 - 2011/10
N2 - Leukemia/lymphoma related factor/POK erythroid myeloid ontogenic factor (LRF/Pokemon) is a member of the POK family of proteins that promotes oncogenesis in several forms of cancer. Recently, we found higher LRF expression in human breast and prostate carcinomas compared to the corresponding normal tissues. The aim of this study was to examine the regulation of LRF expression in human prostate cells. Epidermal growth factor (EGF) and its receptors mediate several tumorigenic cascades that regulate cell differentiation, proliferation, migration and survival of prostate cancer cells. There was significantly higher level of LRF expression in the nucleus of LNCaP and PC-3 cells than RWPE-1 cells. A significant increase in LRF expression was observed with increasing doses of EGF in more aggressive and androgen-sensitive prostate cancer cells suggesting that EGF signaling pathway is critical in upregulating the expression of LRF/Pokemon to promote oncogenesis.
AB - Leukemia/lymphoma related factor/POK erythroid myeloid ontogenic factor (LRF/Pokemon) is a member of the POK family of proteins that promotes oncogenesis in several forms of cancer. Recently, we found higher LRF expression in human breast and prostate carcinomas compared to the corresponding normal tissues. The aim of this study was to examine the regulation of LRF expression in human prostate cells. Epidermal growth factor (EGF) and its receptors mediate several tumorigenic cascades that regulate cell differentiation, proliferation, migration and survival of prostate cancer cells. There was significantly higher level of LRF expression in the nucleus of LNCaP and PC-3 cells than RWPE-1 cells. A significant increase in LRF expression was observed with increasing doses of EGF in more aggressive and androgen-sensitive prostate cancer cells suggesting that EGF signaling pathway is critical in upregulating the expression of LRF/Pokemon to promote oncogenesis.
UR - http://www.scopus.com/inward/record.url?scp=79959214020&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79959214020&partnerID=8YFLogxK
U2 - 10.1016/j.yexmp.2011.05.006
DO - 10.1016/j.yexmp.2011.05.006
M3 - Article
C2 - 21640721
AN - SCOPUS:79959214020
VL - 91
SP - 496
EP - 501
JO - Experimental and Molecular Pathology
JF - Experimental and Molecular Pathology
SN - 0014-4800
IS - 2
ER -