Epidermal growth factor increases LRF/Pokemon expression in human prostate cancer cells

Himanshu Aggarwal, Anshu Aggarwal, Devendra K. Agrawal

    Research output: Contribution to journalArticlepeer-review

    14 Scopus citations

    Abstract

    Leukemia/lymphoma related factor/POK erythroid myeloid ontogenic factor (LRF/Pokemon) is a member of the POK family of proteins that promotes oncogenesis in several forms of cancer. Recently, we found higher LRF expression in human breast and prostate carcinomas compared to the corresponding normal tissues. The aim of this study was to examine the regulation of LRF expression in human prostate cells. Epidermal growth factor (EGF) and its receptors mediate several tumorigenic cascades that regulate cell differentiation, proliferation, migration and survival of prostate cancer cells. There was significantly higher level of LRF expression in the nucleus of LNCaP and PC-3 cells than RWPE-1 cells. A significant increase in LRF expression was observed with increasing doses of EGF in more aggressive and androgen-sensitive prostate cancer cells suggesting that EGF signaling pathway is critical in upregulating the expression of LRF/Pokemon to promote oncogenesis.

    Original languageEnglish
    Pages (from-to)496-501
    Number of pages6
    JournalExperimental and Molecular Pathology
    Volume91
    Issue number2
    DOIs
    StatePublished - Oct 2011

    All Science Journal Classification (ASJC) codes

    • Clinical Biochemistry
    • Molecular Biology
    • Pathology and Forensic Medicine

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