Epidermal growth factor increases LRF/Pokemon expression in human prostate cancer cells

Himanshu Aggarwal, Anshu Aggarwal, Devendra K. Agrawal

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Leukemia/lymphoma related factor/POK erythroid myeloid ontogenic factor (LRF/Pokemon) is a member of the POK family of proteins that promotes oncogenesis in several forms of cancer. Recently, we found higher LRF expression in human breast and prostate carcinomas compared to the corresponding normal tissues. The aim of this study was to examine the regulation of LRF expression in human prostate cells. Epidermal growth factor (EGF) and its receptors mediate several tumorigenic cascades that regulate cell differentiation, proliferation, migration and survival of prostate cancer cells. There was significantly higher level of LRF expression in the nucleus of LNCaP and PC-3 cells than RWPE-1 cells. A significant increase in LRF expression was observed with increasing doses of EGF in more aggressive and androgen-sensitive prostate cancer cells suggesting that EGF signaling pathway is critical in upregulating the expression of LRF/Pokemon to promote oncogenesis.

Original languageEnglish
Pages (from-to)496-501
Number of pages6
JournalExperimental and Molecular Pathology
Volume91
Issue number2
DOIs
StatePublished - Oct 2011

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine

Cite this