Epidermal growth factor increases LRF/Pokemon expression in human prostate cancer cells

Himanshu Aggarwal, Anshu Aggarwal, Devendra K. Agrawal

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Leukemia/lymphoma related factor/POK erythroid myeloid ontogenic factor (LRF/Pokemon) is a member of the POK family of proteins that promotes oncogenesis in several forms of cancer. Recently, we found higher LRF expression in human breast and prostate carcinomas compared to the corresponding normal tissues. The aim of this study was to examine the regulation of LRF expression in human prostate cells. Epidermal growth factor (EGF) and its receptors mediate several tumorigenic cascades that regulate cell differentiation, proliferation, migration and survival of prostate cancer cells. There was significantly higher level of LRF expression in the nucleus of LNCaP and PC-3 cells than RWPE-1 cells. A significant increase in LRF expression was observed with increasing doses of EGF in more aggressive and androgen-sensitive prostate cancer cells suggesting that EGF signaling pathway is critical in upregulating the expression of LRF/Pokemon to promote oncogenesis.

Original languageEnglish
Pages (from-to)496-501
Number of pages6
JournalExperimental and Molecular Pathology
Volume91
Issue number2
DOIs
StatePublished - Oct 2011

Fingerprint

Epidermal Growth Factor
Lymphoma
Prostatic Neoplasms
Cells
Androgens
Tissue
Prostate
Carcinogenesis
Critical Pathways
Proteins
Cell Differentiation
Cell Survival
Leukemia
Cell Proliferation
Breast Neoplasms
Neoplasms
ErbB Receptors

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine

Cite this

Epidermal growth factor increases LRF/Pokemon expression in human prostate cancer cells. / Aggarwal, Himanshu; Aggarwal, Anshu; Agrawal, Devendra K.

In: Experimental and Molecular Pathology, Vol. 91, No. 2, 10.2011, p. 496-501.

Research output: Contribution to journalArticle

@article{d2b8824c14614803ac8a20c412c20054,
title = "Epidermal growth factor increases LRF/Pokemon expression in human prostate cancer cells",
abstract = "Leukemia/lymphoma related factor/POK erythroid myeloid ontogenic factor (LRF/Pokemon) is a member of the POK family of proteins that promotes oncogenesis in several forms of cancer. Recently, we found higher LRF expression in human breast and prostate carcinomas compared to the corresponding normal tissues. The aim of this study was to examine the regulation of LRF expression in human prostate cells. Epidermal growth factor (EGF) and its receptors mediate several tumorigenic cascades that regulate cell differentiation, proliferation, migration and survival of prostate cancer cells. There was significantly higher level of LRF expression in the nucleus of LNCaP and PC-3 cells than RWPE-1 cells. A significant increase in LRF expression was observed with increasing doses of EGF in more aggressive and androgen-sensitive prostate cancer cells suggesting that EGF signaling pathway is critical in upregulating the expression of LRF/Pokemon to promote oncogenesis.",
author = "Himanshu Aggarwal and Anshu Aggarwal and Agrawal, {Devendra K.}",
year = "2011",
month = "10",
doi = "10.1016/j.yexmp.2011.05.006",
language = "English",
volume = "91",
pages = "496--501",
journal = "Experimental and Molecular Pathology",
issn = "0014-4800",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Epidermal growth factor increases LRF/Pokemon expression in human prostate cancer cells

AU - Aggarwal, Himanshu

AU - Aggarwal, Anshu

AU - Agrawal, Devendra K.

PY - 2011/10

Y1 - 2011/10

N2 - Leukemia/lymphoma related factor/POK erythroid myeloid ontogenic factor (LRF/Pokemon) is a member of the POK family of proteins that promotes oncogenesis in several forms of cancer. Recently, we found higher LRF expression in human breast and prostate carcinomas compared to the corresponding normal tissues. The aim of this study was to examine the regulation of LRF expression in human prostate cells. Epidermal growth factor (EGF) and its receptors mediate several tumorigenic cascades that regulate cell differentiation, proliferation, migration and survival of prostate cancer cells. There was significantly higher level of LRF expression in the nucleus of LNCaP and PC-3 cells than RWPE-1 cells. A significant increase in LRF expression was observed with increasing doses of EGF in more aggressive and androgen-sensitive prostate cancer cells suggesting that EGF signaling pathway is critical in upregulating the expression of LRF/Pokemon to promote oncogenesis.

AB - Leukemia/lymphoma related factor/POK erythroid myeloid ontogenic factor (LRF/Pokemon) is a member of the POK family of proteins that promotes oncogenesis in several forms of cancer. Recently, we found higher LRF expression in human breast and prostate carcinomas compared to the corresponding normal tissues. The aim of this study was to examine the regulation of LRF expression in human prostate cells. Epidermal growth factor (EGF) and its receptors mediate several tumorigenic cascades that regulate cell differentiation, proliferation, migration and survival of prostate cancer cells. There was significantly higher level of LRF expression in the nucleus of LNCaP and PC-3 cells than RWPE-1 cells. A significant increase in LRF expression was observed with increasing doses of EGF in more aggressive and androgen-sensitive prostate cancer cells suggesting that EGF signaling pathway is critical in upregulating the expression of LRF/Pokemon to promote oncogenesis.

UR - http://www.scopus.com/inward/record.url?scp=79959214020&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959214020&partnerID=8YFLogxK

U2 - 10.1016/j.yexmp.2011.05.006

DO - 10.1016/j.yexmp.2011.05.006

M3 - Article

C2 - 21640721

AN - SCOPUS:79959214020

VL - 91

SP - 496

EP - 501

JO - Experimental and Molecular Pathology

JF - Experimental and Molecular Pathology

SN - 0014-4800

IS - 2

ER -