Abstract
Exposure to ultraviolet (UV) irradiation is the major cause of nonmelanoma skin cancer, the most common form of cancer in the United States. UV irradiation has a variety of effects on the skin associated with carcinogenesis, including DNA damage and effects on signal transduction. The alterations in signaling caused by UV regulate inflammation, cell proliferation, and apoptosis. UV also activates the orphan receptor tyrosine kinase and proto-oncogene Erbb2 (HER2/neu). In this study, we demonstrate that the UV-induced activation of Erbb2 regulates the response of the skin to UV. Inhibition or knockdown of Erbb2 before UV irradiation suppressed cell proliferation, cell survival, and inflammation after UV. In addition, Erbb2 was necessary for the UV-induced expression of numerous proinflammatory genes that are regulated by the transcription factors nuclear factor-κB and Comp1, including interleukin-1β, prostaglandinendoperoxidase synthase 2 (Cyclooxygenase-2), and multiple chemokines. These results reveal the influence of Erbb2 on the UV response and suggest a role for Erbb2 in UV-induced pathologies such as skin cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 1402-1414 |
| Number of pages | 13 |
| Journal | American Journal of Pathology |
| Volume | 169 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 2006 |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
Cite this
Erbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation. / Madson, Justin G.; Lynch, David T.; Tinkum, Kelsey L.; Putta, Sumanth K.; Hansen, Laura A.
In: American Journal of Pathology, Vol. 169, No. 4, 10.2006, p. 1402-1414.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Erbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation
AU - Madson, Justin G.
AU - Lynch, David T.
AU - Tinkum, Kelsey L.
AU - Putta, Sumanth K.
AU - Hansen, Laura A.
PY - 2006/10
Y1 - 2006/10
N2 - Exposure to ultraviolet (UV) irradiation is the major cause of nonmelanoma skin cancer, the most common form of cancer in the United States. UV irradiation has a variety of effects on the skin associated with carcinogenesis, including DNA damage and effects on signal transduction. The alterations in signaling caused by UV regulate inflammation, cell proliferation, and apoptosis. UV also activates the orphan receptor tyrosine kinase and proto-oncogene Erbb2 (HER2/neu). In this study, we demonstrate that the UV-induced activation of Erbb2 regulates the response of the skin to UV. Inhibition or knockdown of Erbb2 before UV irradiation suppressed cell proliferation, cell survival, and inflammation after UV. In addition, Erbb2 was necessary for the UV-induced expression of numerous proinflammatory genes that are regulated by the transcription factors nuclear factor-κB and Comp1, including interleukin-1β, prostaglandinendoperoxidase synthase 2 (Cyclooxygenase-2), and multiple chemokines. These results reveal the influence of Erbb2 on the UV response and suggest a role for Erbb2 in UV-induced pathologies such as skin cancer.
AB - Exposure to ultraviolet (UV) irradiation is the major cause of nonmelanoma skin cancer, the most common form of cancer in the United States. UV irradiation has a variety of effects on the skin associated with carcinogenesis, including DNA damage and effects on signal transduction. The alterations in signaling caused by UV regulate inflammation, cell proliferation, and apoptosis. UV also activates the orphan receptor tyrosine kinase and proto-oncogene Erbb2 (HER2/neu). In this study, we demonstrate that the UV-induced activation of Erbb2 regulates the response of the skin to UV. Inhibition or knockdown of Erbb2 before UV irradiation suppressed cell proliferation, cell survival, and inflammation after UV. In addition, Erbb2 was necessary for the UV-induced expression of numerous proinflammatory genes that are regulated by the transcription factors nuclear factor-κB and Comp1, including interleukin-1β, prostaglandinendoperoxidase synthase 2 (Cyclooxygenase-2), and multiple chemokines. These results reveal the influence of Erbb2 on the UV response and suggest a role for Erbb2 in UV-induced pathologies such as skin cancer.
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U2 - 10.2353/ajpath.2006.060082
DO - 10.2353/ajpath.2006.060082
M3 - Article
VL - 169
SP - 1402
EP - 1414
JO - American Journal of Pathology
JF - American Journal of Pathology
SN - 0002-9440
IS - 4
ER -