Erbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation

Justin G. Madson, David T. Lynch, Kelsey L. Tinkum, Sumanth K. Putta, Laura A. Hansen

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Exposure to ultraviolet (UV) irradiation is the major cause of nonmelanoma skin cancer, the most common form of cancer in the United States. UV irradiation has a variety of effects on the skin associated with carcinogenesis, including DNA damage and effects on signal transduction. The alterations in signaling caused by UV regulate inflammation, cell proliferation, and apoptosis. UV also activates the orphan receptor tyrosine kinase and proto-oncogene Erbb2 (HER2/neu). In this study, we demonstrate that the UV-induced activation of Erbb2 regulates the response of the skin to UV. Inhibition or knockdown of Erbb2 before UV irradiation suppressed cell proliferation, cell survival, and inflammation after UV. In addition, Erbb2 was necessary for the UV-induced expression of numerous proinflammatory genes that are regulated by the transcription factors nuclear factor-κB and Comp1, including interleukin-1β, prostaglandinendoperoxidase synthase 2 (Cyclooxygenase-2), and multiple chemokines. These results reveal the influence of Erbb2 on the UV response and suggest a role for Erbb2 in UV-induced pathologies such as skin cancer.

Original languageEnglish
Pages (from-to)1402-1414
Number of pages13
JournalAmerican Journal of Pathology
Volume169
Issue number4
DOIs
StatePublished - Oct 2006

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Skin Neoplasms
Cell Proliferation
Inflammation
Skin
Proto-Oncogenes
Receptor Protein-Tyrosine Kinases
Cyclooxygenase 2
Interleukin-1
Chemokines
DNA Damage
Signal Transduction
Cell Survival
Carcinogenesis
Transcription Factors
Apoptosis
Pathology
Genes
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Erbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation. / Madson, Justin G.; Lynch, David T.; Tinkum, Kelsey L.; Putta, Sumanth K.; Hansen, Laura A.

In: American Journal of Pathology, Vol. 169, No. 4, 10.2006, p. 1402-1414.

Research output: Contribution to journalArticle

Madson, Justin G. ; Lynch, David T. ; Tinkum, Kelsey L. ; Putta, Sumanth K. ; Hansen, Laura A. / Erbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation. In: American Journal of Pathology. 2006 ; Vol. 169, No. 4. pp. 1402-1414.
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