Escherichia coli: development of carbapenem resistance during therapy.

Tao Hong, Ellen Smith Moland, Baha Abdalhamid, Nancy D. Hanson, Jie Wang, Cindy Sloan, Diane Fabian, Awny Farajallah, Jerome Levine, Kenneth S. Thomson

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

A 76-year-old woman had recurrent urosepsis due to extended-spectrum beta -lactamase-positive Escherichia coli. Imipenem resistance was detected after long-term imipenem-meropenem therapy. The carbapenem-hydrolyzing enzyme gene was identified as blaKPC-3. To our knowledge, this is the first documented case in which carbapenem-resistant E. coli emerged during therapy with imipenem and meropenem, and the first identification of the carbapenem-hydrolyzing enzyme in E. coli isolates.

Original languageEnglish
JournalClinical Infectious Diseases
Volume40
Issue number10
StatePublished - 2005
Externally publishedYes

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meropenem
Carbapenems
Imipenem
Escherichia coli
Enzymes
beta-Lactamases
Therapeutics
Genes

Cite this

Hong, T., Moland, E. S., Abdalhamid, B., Hanson, N. D., Wang, J., Sloan, C., ... Thomson, K. S. (2005). Escherichia coli: development of carbapenem resistance during therapy. Clinical Infectious Diseases, 40(10).

Escherichia coli : development of carbapenem resistance during therapy. / Hong, Tao; Moland, Ellen Smith; Abdalhamid, Baha; Hanson, Nancy D.; Wang, Jie; Sloan, Cindy; Fabian, Diane; Farajallah, Awny; Levine, Jerome; Thomson, Kenneth S.

In: Clinical Infectious Diseases, Vol. 40, No. 10, 2005.

Research output: Contribution to journalArticle

Hong, T, Moland, ES, Abdalhamid, B, Hanson, ND, Wang, J, Sloan, C, Fabian, D, Farajallah, A, Levine, J & Thomson, KS 2005, 'Escherichia coli: development of carbapenem resistance during therapy.', Clinical Infectious Diseases, vol. 40, no. 10.
Hong, Tao ; Moland, Ellen Smith ; Abdalhamid, Baha ; Hanson, Nancy D. ; Wang, Jie ; Sloan, Cindy ; Fabian, Diane ; Farajallah, Awny ; Levine, Jerome ; Thomson, Kenneth S. / Escherichia coli : development of carbapenem resistance during therapy. In: Clinical Infectious Diseases. 2005 ; Vol. 40, No. 10.
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