Abstract
Background: Supraventricular tachyarrhythmias are common after open heart surgery. Possible causative factors for these arrhythmias include operative trauma, atrial ischemia, electrolyte imbalances, pericardial irritation, and excess catecholamines. Two agents commonly used to control ventricular rate in atrial fibrillation or atrial flutter (AF/AFL) are β- blockers and calcium channel blockers. Methods and Results: This randomized study was designed to compare the safety and efficacy of intravenous diltiazem versus intravenous esmolol in patients with postoperative AF/AFL after coronary bypass surgery and/or valve replacement surgery. A comparative cost analysis was also performed. Thirty patients received either esmolol (n = 15) or diltiazem (n = 15) for AF/AFL. During the first 6 hours of treatment, 66.6% of esmolol-treated patients converted to sinus rhythm compared with 13.3% of the diltiazem-treated patients (P <.05). At 24 hours, 66.6% of the diltiazem group converted to SR compared with 80% of the esmolol group (not significant). Drug-induced side effects, time to rate control (
| Original language | English |
|---|---|
| Pages (from-to) | 176-180 |
| Number of pages | 5 |
| Journal | American Heart Journal |
| Volume | 140 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 2000 |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
Cite this
Esmolol versus diltiazem in the treatment of postoperative atrial fibrillation/atrial flutter after open heart surgery. / Mooss, Aryan N.; Wurdeman, Richard L.; Mohiuddin, Syed M.; Reyes, Antonio P.; Sugimoto, Jeffrey T.; Scott, Walter; Hilleman, Daniel E.; Seyedroudbari, Ali.
In: American Heart Journal, Vol. 140, No. 1, 07.2000, p. 176-180.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Esmolol versus diltiazem in the treatment of postoperative atrial fibrillation/atrial flutter after open heart surgery
AU - Mooss, Aryan N.
AU - Wurdeman, Richard L.
AU - Mohiuddin, Syed M.
AU - Reyes, Antonio P.
AU - Sugimoto, Jeffrey T.
AU - Scott, Walter
AU - Hilleman, Daniel E.
AU - Seyedroudbari, Ali
PY - 2000/7
Y1 - 2000/7
N2 - Background: Supraventricular tachyarrhythmias are common after open heart surgery. Possible causative factors for these arrhythmias include operative trauma, atrial ischemia, electrolyte imbalances, pericardial irritation, and excess catecholamines. Two agents commonly used to control ventricular rate in atrial fibrillation or atrial flutter (AF/AFL) are β- blockers and calcium channel blockers. Methods and Results: This randomized study was designed to compare the safety and efficacy of intravenous diltiazem versus intravenous esmolol in patients with postoperative AF/AFL after coronary bypass surgery and/or valve replacement surgery. A comparative cost analysis was also performed. Thirty patients received either esmolol (n = 15) or diltiazem (n = 15) for AF/AFL. During the first 6 hours of treatment, 66.6% of esmolol-treated patients converted to sinus rhythm compared with 13.3% of the diltiazem-treated patients (P <.05). At 24 hours, 66.6% of the diltiazem group converted to SR compared with 80% of the esmolol group (not significant). Drug-induced side effects, time to rate control (
AB - Background: Supraventricular tachyarrhythmias are common after open heart surgery. Possible causative factors for these arrhythmias include operative trauma, atrial ischemia, electrolyte imbalances, pericardial irritation, and excess catecholamines. Two agents commonly used to control ventricular rate in atrial fibrillation or atrial flutter (AF/AFL) are β- blockers and calcium channel blockers. Methods and Results: This randomized study was designed to compare the safety and efficacy of intravenous diltiazem versus intravenous esmolol in patients with postoperative AF/AFL after coronary bypass surgery and/or valve replacement surgery. A comparative cost analysis was also performed. Thirty patients received either esmolol (n = 15) or diltiazem (n = 15) for AF/AFL. During the first 6 hours of treatment, 66.6% of esmolol-treated patients converted to sinus rhythm compared with 13.3% of the diltiazem-treated patients (P <.05). At 24 hours, 66.6% of the diltiazem group converted to SR compared with 80% of the esmolol group (not significant). Drug-induced side effects, time to rate control (
UR - http://www.scopus.com/inward/record.url?scp=0033928714&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033928714&partnerID=8YFLogxK
U2 - 10.1067/mhj.2000.106917
DO - 10.1067/mhj.2000.106917
M3 - Article
C2 - 10874282
AN - SCOPUS:0033928714
VL - 140
SP - 176
EP - 180
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 1
ER -