Establishment of a model to examine the early events involved in the development of virus-induced demyelinating lesions

Kristen M. Drescher, Steven Tracy

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The ability to study the immediate, early events in the demyelinating process has been difficult on account of the lack of model systems that address this phase of lesion development. The vast majority of animal models used to study multiple sclerosis (MS) focuses on the later events of myelin destruction. To address this deficiency, we have modified the currently used Theiler's murine encephalomyelitis virus (TMEV)-induced model of demyelination to precisely identify the area where virus-induced demyelination first occurs. Following surgical exposure of the spinal cord, we directly injected TMEV into the spinal cord of female SJL/J mice. Characterization of the events in the spinal cord in the days following injection of virus support the use of this model to dissect the pathways triggered in the host in the early phases of demyelination. A complete understanding of the genesis of the sclerotic plaque may provide insights into enhanced treatment for patients with central nervous system (CNS) demyelination.

Original languageEnglish (US)
Title of host publicationHow Do We Best Employ Animal Models for Type 1 Diabetesand Multiple Sclerosis
PublisherBlackwell Publishing Inc.
Pages152-156
Number of pages5
ISBN (Print)1573316784, 9781573316781
DOIs
StatePublished - Apr 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1103
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Drescher, K. M., & Tracy, S. (2007). Establishment of a model to examine the early events involved in the development of virus-induced demyelinating lesions. In How Do We Best Employ Animal Models for Type 1 Diabetesand Multiple Sclerosis (pp. 152-156). (Annals of the New York Academy of Sciences; Vol. 1103). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1394.010