Abstract
The ability to study the immediate, early events in the demyelinating process has been difficult on account of the lack of model systems that address this phase of lesion development. The vast majority of animal models used to study multiple sclerosis (MS) focuses on the later events of myelin destruction. To address this deficiency, we have modified the currently used Theiler's murine encephalomyelitis virus (TMEV)-induced model of demyelination to precisely identify the area where virus-induced demyelination first occurs. Following surgical exposure of the spinal cord, we directly injected TMEV into the spinal cord of female SJL/J mice. Characterization of the events in the spinal cord in the days following injection of virus support the use of this model to dissect the pathways triggered in the host in the early phases of demyelination. A complete understanding of the genesis of the sclerotic plaque may provide insights into enhanced treatment for patients with central nervous system (CNS) demyelination.
| Original language | English |
|---|---|
| Title of host publication | How Do We Best Employ Animal Models for Type 1 Diabetesand Multiple Sclerosis |
| Pages | 152-156 |
| Number of pages | 5 |
| Volume | 1103 |
| DOIs | |
| State | Published - Apr 2007 |
Publication series
| Name | Annals of the New York Academy of Sciences |
|---|---|
| Volume | 1103 |
| ISSN (Print) | 00778923 |
| ISSN (Electronic) | 17496632 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Establishment of a model to examine the early events involved in the development of virus-induced demyelinating lesions. / Drescher, Kristen M.; Tracy, Steven.
How Do We Best Employ Animal Models for Type 1 Diabetesand Multiple Sclerosis. Vol. 1103 2007. p. 152-156 (Annals of the New York Academy of Sciences; Vol. 1103).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Establishment of a model to examine the early events involved in the development of virus-induced demyelinating lesions
AU - Drescher, Kristen M.
AU - Tracy, Steven
PY - 2007/4
Y1 - 2007/4
N2 - The ability to study the immediate, early events in the demyelinating process has been difficult on account of the lack of model systems that address this phase of lesion development. The vast majority of animal models used to study multiple sclerosis (MS) focuses on the later events of myelin destruction. To address this deficiency, we have modified the currently used Theiler's murine encephalomyelitis virus (TMEV)-induced model of demyelination to precisely identify the area where virus-induced demyelination first occurs. Following surgical exposure of the spinal cord, we directly injected TMEV into the spinal cord of female SJL/J mice. Characterization of the events in the spinal cord in the days following injection of virus support the use of this model to dissect the pathways triggered in the host in the early phases of demyelination. A complete understanding of the genesis of the sclerotic plaque may provide insights into enhanced treatment for patients with central nervous system (CNS) demyelination.
AB - The ability to study the immediate, early events in the demyelinating process has been difficult on account of the lack of model systems that address this phase of lesion development. The vast majority of animal models used to study multiple sclerosis (MS) focuses on the later events of myelin destruction. To address this deficiency, we have modified the currently used Theiler's murine encephalomyelitis virus (TMEV)-induced model of demyelination to precisely identify the area where virus-induced demyelination first occurs. Following surgical exposure of the spinal cord, we directly injected TMEV into the spinal cord of female SJL/J mice. Characterization of the events in the spinal cord in the days following injection of virus support the use of this model to dissect the pathways triggered in the host in the early phases of demyelination. A complete understanding of the genesis of the sclerotic plaque may provide insights into enhanced treatment for patients with central nervous system (CNS) demyelination.
UR - http://www.scopus.com/inward/record.url?scp=34249025159&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34249025159&partnerID=8YFLogxK
U2 - 10.1196/annals.1394.010
DO - 10.1196/annals.1394.010
M3 - Chapter
SN - 1573316784
SN - 9781573316781
VL - 1103
T3 - Annals of the New York Academy of Sciences
SP - 152
EP - 156
BT - How Do We Best Employ Animal Models for Type 1 Diabetesand Multiple Sclerosis
ER -