TY - JOUR
T1 - Estimation of total incremental health care costs in patients with atrial fibrillation in the united states
AU - Kim, Michael H.
AU - Johnston, Stephen S.
AU - Chu, Bong Chul
AU - Dalal, Mehul R.
AU - Schulman, Kathy L.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2011/5
Y1 - 2011/5
N2 - Background: Detailed information on the cost burden of atrial fibrillation (AF) is limitedTo provide an up-to-date estimate of the national cost of AF, we conducted a retrospective, observational cohort study using administrative claims from the MarketScan Commercial and Medicare Supplemental research data bases, 2004 to 2006Methods and Results: Patients aged ≥20 years with ≥1 inpatient or ≥2 outpatient AF diagnoses in 2005 (first diagnosis=index) and ≥12 months' enrollment before and after index were selectedAF patients were propensity score-matched (1:1) with non-AF control subjectsMedical costs (2008 US$), including AF costs, other cardiovascular, and noncardiovascular costs, were examined over 1 year after indexNational incremental costs of AF were based on age-/sex-specific AF prevalence projections for 2010In total, 89 066 AF patients were matched to non-AF control subjectsOver 1 year, 37.5% of AF versus 17.5% of control subjects were hospitalized and 2.1% versus 0.1% died during hospitalizationFor AF versus control subjects, mean annual inpatient costs per patient were $7841 versus $2622 (incremental cost, $5218), outpatient medical costs were $9225 versus $5629 ($3596), and outpatient pharmacy costs were $3605 versus $3714 (-$109) (all P<0.001)The total incremental cost of AF was $8705 per patientThe national incremental cost of AF was $26.0 billion (AF, $6.0 billion; other cardiovascular, $9.9 billion; noncardiovascular, $10.1 billion)Cardiovascular costs were based on claims with a primary disease diagnosis and may be underestimatesConclusions: On the basis of current US age- and sex-specific prevalence data, the national incremental AF cost is estimated to range from $6.0 to $26.0 billion.
AB - Background: Detailed information on the cost burden of atrial fibrillation (AF) is limitedTo provide an up-to-date estimate of the national cost of AF, we conducted a retrospective, observational cohort study using administrative claims from the MarketScan Commercial and Medicare Supplemental research data bases, 2004 to 2006Methods and Results: Patients aged ≥20 years with ≥1 inpatient or ≥2 outpatient AF diagnoses in 2005 (first diagnosis=index) and ≥12 months' enrollment before and after index were selectedAF patients were propensity score-matched (1:1) with non-AF control subjectsMedical costs (2008 US$), including AF costs, other cardiovascular, and noncardiovascular costs, were examined over 1 year after indexNational incremental costs of AF were based on age-/sex-specific AF prevalence projections for 2010In total, 89 066 AF patients were matched to non-AF control subjectsOver 1 year, 37.5% of AF versus 17.5% of control subjects were hospitalized and 2.1% versus 0.1% died during hospitalizationFor AF versus control subjects, mean annual inpatient costs per patient were $7841 versus $2622 (incremental cost, $5218), outpatient medical costs were $9225 versus $5629 ($3596), and outpatient pharmacy costs were $3605 versus $3714 (-$109) (all P<0.001)The total incremental cost of AF was $8705 per patientThe national incremental cost of AF was $26.0 billion (AF, $6.0 billion; other cardiovascular, $9.9 billion; noncardiovascular, $10.1 billion)Cardiovascular costs were based on claims with a primary disease diagnosis and may be underestimatesConclusions: On the basis of current US age- and sex-specific prevalence data, the national incremental AF cost is estimated to range from $6.0 to $26.0 billion.
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U2 - 10.1161/CIRCOUTCOMES.110.958165
DO - 10.1161/CIRCOUTCOMES.110.958165
M3 - Article
C2 - 21540439
AN - SCOPUS:79959736442
VL - 4
SP - 313
EP - 320
JO - Circulation: Cardiovascular Quality and Outcomes
JF - Circulation: Cardiovascular Quality and Outcomes
SN - 1941-7713
IS - 3
ER -