Abstract
Measurements of true calcium absorption fraction in women were evaluated to see how closely calculations based on a single measurement of serum specific activity after administration of an oral calcium tracer might approximate the absorption value derived from the full, double-isotope absorption procedure. True absorption, body size, and miscible pool turnover could together explain better than 93% of the variance in serum calcium specific activity values 5 hours after a tracer-labeled test meal. Because measurement of pool turnover is not available routinely, it was dropped from the model, and a predictor equation was developed that allowed estimation of true absorption from the 5-hour serum specific activity value, height, and weight. These variables explained 90.8% of the variance in the 5-hour values and gave estimates of true absorption with a 95% confidence interval of +/- 0.055. This small range of uncertainty makes the procedure useful in estimating absorption efficiency for calcium therapy in routine clinical practice.
| Original language | English |
|---|---|
| Pages (from-to) | 516-521 |
| Number of pages | 6 |
| Journal | Annals of Internal Medicine |
| Volume | 103 |
| Issue number | 4 |
| State | Published - Oct 1985 |
| Externally published | Yes |
Fingerprint
All Science Journal Classification (ASJC) codes
- Medicine(all)
Cite this
Estimation of true calcium absorption. / Heaney, R. P.; Recker, Robert R.
In: Annals of Internal Medicine, Vol. 103, No. 4, 10.1985, p. 516-521.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Estimation of true calcium absorption.
AU - Heaney, R. P.
AU - Recker, Robert R.
PY - 1985/10
Y1 - 1985/10
N2 - Measurements of true calcium absorption fraction in women were evaluated to see how closely calculations based on a single measurement of serum specific activity after administration of an oral calcium tracer might approximate the absorption value derived from the full, double-isotope absorption procedure. True absorption, body size, and miscible pool turnover could together explain better than 93% of the variance in serum calcium specific activity values 5 hours after a tracer-labeled test meal. Because measurement of pool turnover is not available routinely, it was dropped from the model, and a predictor equation was developed that allowed estimation of true absorption from the 5-hour serum specific activity value, height, and weight. These variables explained 90.8% of the variance in the 5-hour values and gave estimates of true absorption with a 95% confidence interval of +/- 0.055. This small range of uncertainty makes the procedure useful in estimating absorption efficiency for calcium therapy in routine clinical practice.
AB - Measurements of true calcium absorption fraction in women were evaluated to see how closely calculations based on a single measurement of serum specific activity after administration of an oral calcium tracer might approximate the absorption value derived from the full, double-isotope absorption procedure. True absorption, body size, and miscible pool turnover could together explain better than 93% of the variance in serum calcium specific activity values 5 hours after a tracer-labeled test meal. Because measurement of pool turnover is not available routinely, it was dropped from the model, and a predictor equation was developed that allowed estimation of true absorption from the 5-hour serum specific activity value, height, and weight. These variables explained 90.8% of the variance in the 5-hour values and gave estimates of true absorption with a 95% confidence interval of +/- 0.055. This small range of uncertainty makes the procedure useful in estimating absorption efficiency for calcium therapy in routine clinical practice.
UR - http://www.scopus.com/inward/record.url?scp=0022134597&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022134597&partnerID=8YFLogxK
M3 - Article
VL - 103
SP - 516
EP - 521
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
SN - 0003-4819
IS - 4
ER -