Estrogen Receptor α Gene Polymorphisms and Peak Bone Density in Chinese Nuclear Families

Yue Juan Qin, Hui Shen, Qi Ren Huang, Lan Juan Zhao, Qi Zhou, Miao Xin Li, Jin Wei He, Xiao Yang Mo, Jing Hui Lu, Robert R. Recker, Hong Wen Deng

Research output: Contribution to journalArticle

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Abstract

PBD is an important determinant of osteoporotic fractures. Few studies were performed to search for genes underlying PBD variation in Chinese populations. We tested linkage and/or association of the estrogen receptor α gene polymorphism with PBD in 401 Chinese nuclear families. This study suggests the ER-α gene may have some minor effects on PBM variation in the Chinese population. Low peak bone density (PBD) in adulthood is an important determinant of osteoporotic fractures in the elderly. PBD variation is mainly regulated by genetic factors. Extensive molecular genetics studies have been performed to search for genes underlying PBD variation, largely in whites. Few studies were performed in Chinese populations. In this study, we simultaneously test linkage and/or association of the estrogen receptor α (ER-α) gene polymorphism with PBD in 401 Chinese nuclear families (both parents plus their female children) of 1260 subjects, with the 458 children generally between 20 and 40 years of age. All the subjects were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) at polymorphic PvuII and XbaI sites inside the ER-α gene. Bone mineral density was measured at the lumbar spine (L1-L4) and hip (femoral neck, trochanter, and intertrochanteric region). Raw bone mineral density values were adjusted by age, height, and weight as covariates. We detected marginally significant results for within-family association (transmission disequilibrium; p = 0.054) between the spine bone mineral density variation and the ER-α XbaI genotypes. For the hip bone mineral density variation, significant (p <0.05) linkage results were generally found for the two intragenic markers. Analyses of the haplotypes defined by the two markers confer further evidence for linkage of the ER-α with the hip PBD variation. In conclusion, this study suggests that the ER-α gene may have minor effects on PBD variation in our Chinese population.

Original languageEnglish
Pages (from-to)1028-1035
Number of pages8
JournalJournal of Bone and Mineral Research
Volume18
Issue number6
DOIs
StatePublished - Jun 1 2003

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Nuclear Family
Estrogen Receptors
Bone Density
Genes
Pelvic Bones
Osteoporotic Fractures
Population
Spine
Femur Neck
Restriction Fragment Length Polymorphisms
Femur
Haplotypes
Hip
Molecular Biology
Parents
Genotype

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Qin, Y. J., Shen, H., Huang, Q. R., Zhao, L. J., Zhou, Q., Li, M. X., ... Deng, H. W. (2003). Estrogen Receptor α Gene Polymorphisms and Peak Bone Density in Chinese Nuclear Families. Journal of Bone and Mineral Research, 18(6), 1028-1035. https://doi.org/10.1359/jbmr.2003.18.6.1028

Estrogen Receptor α Gene Polymorphisms and Peak Bone Density in Chinese Nuclear Families. / Qin, Yue Juan; Shen, Hui; Huang, Qi Ren; Zhao, Lan Juan; Zhou, Qi; Li, Miao Xin; He, Jin Wei; Mo, Xiao Yang; Lu, Jing Hui; Recker, Robert R.; Deng, Hong Wen.

In: Journal of Bone and Mineral Research, Vol. 18, No. 6, 01.06.2003, p. 1028-1035.

Research output: Contribution to journalArticle

Qin, YJ, Shen, H, Huang, QR, Zhao, LJ, Zhou, Q, Li, MX, He, JW, Mo, XY, Lu, JH, Recker, RR & Deng, HW 2003, 'Estrogen Receptor α Gene Polymorphisms and Peak Bone Density in Chinese Nuclear Families', Journal of Bone and Mineral Research, vol. 18, no. 6, pp. 1028-1035. https://doi.org/10.1359/jbmr.2003.18.6.1028
Qin, Yue Juan ; Shen, Hui ; Huang, Qi Ren ; Zhao, Lan Juan ; Zhou, Qi ; Li, Miao Xin ; He, Jin Wei ; Mo, Xiao Yang ; Lu, Jing Hui ; Recker, Robert R. ; Deng, Hong Wen. / Estrogen Receptor α Gene Polymorphisms and Peak Bone Density in Chinese Nuclear Families. In: Journal of Bone and Mineral Research. 2003 ; Vol. 18, No. 6. pp. 1028-1035.
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