Estrogens in the prevention of osteoporosis in postmenopausal women

Harry K. Genant, David J. Baylink, J. C. Gallagher

Research output: Contribution to journalArticlepeer-review

144 Scopus citations


Menopausal-related bone loss leaves a woman at high risk for fractures. Estrogen use by postmenopausal women, especially when started within 3 years of the last menstrual period, prevents bone loss and reduces the risk of osteoporotic fractures. Estrogens do not restore lost bone. Withdrawal of estrogen therapy is followed by significant bone loss, thus suggesting that long-term therapy is needed. Concomitant progesterone therapy does not impair estrogen's bone-preserving activity.

Original languageEnglish (US)
Pages (from-to)1842-1846
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Issue number6
StatePublished - 1989

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology


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