Evaluation of quick disintegrating calcium carbonate tablets

Hector Fausett, Charles Gayser, Alekha K. Dash

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The purpose of this investigation was to develop a rapidly disintegrating calcium carbonate (CC) tablet by direct compression and compare it with commercially available calcium tablets. CC tablets were formulated on a Carver press using 3 different forms of CC direct compressed granules (Cal-Carb 4450®, Cal-Carb 4457®, and Cal-Carb 4462®). The breaking strength was measured using a Stokes-Monsanto hardness tester. The disintegration and dissolution properties of the tablets were studied using USP methodology. The calcium concentration was determined by an atomic absorption spectrophotometer. Scanning electron microscopy was used to evaluate the surface topography of the granules and tablets. Breaking strength of Cal-Carb 4450®, Cal-Carb 4457R, and Cal-Carb 4462® tablets was in the range of 7.2 to 7.7 kg, as compared with a hardness of 6.2 kg and 10 kg for the commercially available calcium tablets Citracal® and Tumsr, respectively. The disintegration time for the tablets presented in the order earlier was 4.1, 2.1, 1.9, 2.9, and 9.7 minutes, respectively. The dissolution studies showed that all formulations released 100% of the elemental calcium in simulated gastric fluid in less than 20 minutes. In summary, this study clearly demonstrated that quick disintegrating CC tablets can be formulated without expensive effervescence technology.

Original languageEnglish
JournalAAPS PharmSciTech
Volume1
Issue number3
StatePublished - 2000

Fingerprint

Calcium Carbonate
calcium carbonate
Tablets
calcium
hardness
granules
Calcium
spectrophotometers
Hardness
topography
stomach
scanning electron microscopy
Electron Scanning Microscopy
Stomach
Technology
methodology

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmaceutical Science

Cite this

Evaluation of quick disintegrating calcium carbonate tablets. / Fausett, Hector; Gayser, Charles; Dash, Alekha K.

In: AAPS PharmSciTech, Vol. 1, No. 3, 2000.

Research output: Contribution to journalArticle

Fausett, Hector ; Gayser, Charles ; Dash, Alekha K. / Evaluation of quick disintegrating calcium carbonate tablets. In: AAPS PharmSciTech. 2000 ; Vol. 1, No. 3.
@article{91552bb987944150acdf340652f7234f,
title = "Evaluation of quick disintegrating calcium carbonate tablets",
abstract = "The purpose of this investigation was to develop a rapidly disintegrating calcium carbonate (CC) tablet by direct compression and compare it with commercially available calcium tablets. CC tablets were formulated on a Carver press using 3 different forms of CC direct compressed granules (Cal-Carb 4450{\circledR}, Cal-Carb 4457{\circledR}, and Cal-Carb 4462{\circledR}). The breaking strength was measured using a Stokes-Monsanto hardness tester. The disintegration and dissolution properties of the tablets were studied using USP methodology. The calcium concentration was determined by an atomic absorption spectrophotometer. Scanning electron microscopy was used to evaluate the surface topography of the granules and tablets. Breaking strength of Cal-Carb 4450{\circledR}, Cal-Carb 4457R, and Cal-Carb 4462{\circledR} tablets was in the range of 7.2 to 7.7 kg, as compared with a hardness of 6.2 kg and 10 kg for the commercially available calcium tablets Citracal{\circledR} and Tumsr, respectively. The disintegration time for the tablets presented in the order earlier was 4.1, 2.1, 1.9, 2.9, and 9.7 minutes, respectively. The dissolution studies showed that all formulations released 100{\%} of the elemental calcium in simulated gastric fluid in less than 20 minutes. In summary, this study clearly demonstrated that quick disintegrating CC tablets can be formulated without expensive effervescence technology.",
author = "Hector Fausett and Charles Gayser and Dash, {Alekha K.}",
year = "2000",
language = "English",
volume = "1",
journal = "AAPS PharmSciTech",
issn = "1530-9932",
publisher = "American Association of Pharmaceutical Scientists",
number = "3",

}

TY - JOUR

T1 - Evaluation of quick disintegrating calcium carbonate tablets

AU - Fausett, Hector

AU - Gayser, Charles

AU - Dash, Alekha K.

PY - 2000

Y1 - 2000

N2 - The purpose of this investigation was to develop a rapidly disintegrating calcium carbonate (CC) tablet by direct compression and compare it with commercially available calcium tablets. CC tablets were formulated on a Carver press using 3 different forms of CC direct compressed granules (Cal-Carb 4450®, Cal-Carb 4457®, and Cal-Carb 4462®). The breaking strength was measured using a Stokes-Monsanto hardness tester. The disintegration and dissolution properties of the tablets were studied using USP methodology. The calcium concentration was determined by an atomic absorption spectrophotometer. Scanning electron microscopy was used to evaluate the surface topography of the granules and tablets. Breaking strength of Cal-Carb 4450®, Cal-Carb 4457R, and Cal-Carb 4462® tablets was in the range of 7.2 to 7.7 kg, as compared with a hardness of 6.2 kg and 10 kg for the commercially available calcium tablets Citracal® and Tumsr, respectively. The disintegration time for the tablets presented in the order earlier was 4.1, 2.1, 1.9, 2.9, and 9.7 minutes, respectively. The dissolution studies showed that all formulations released 100% of the elemental calcium in simulated gastric fluid in less than 20 minutes. In summary, this study clearly demonstrated that quick disintegrating CC tablets can be formulated without expensive effervescence technology.

AB - The purpose of this investigation was to develop a rapidly disintegrating calcium carbonate (CC) tablet by direct compression and compare it with commercially available calcium tablets. CC tablets were formulated on a Carver press using 3 different forms of CC direct compressed granules (Cal-Carb 4450®, Cal-Carb 4457®, and Cal-Carb 4462®). The breaking strength was measured using a Stokes-Monsanto hardness tester. The disintegration and dissolution properties of the tablets were studied using USP methodology. The calcium concentration was determined by an atomic absorption spectrophotometer. Scanning electron microscopy was used to evaluate the surface topography of the granules and tablets. Breaking strength of Cal-Carb 4450®, Cal-Carb 4457R, and Cal-Carb 4462® tablets was in the range of 7.2 to 7.7 kg, as compared with a hardness of 6.2 kg and 10 kg for the commercially available calcium tablets Citracal® and Tumsr, respectively. The disintegration time for the tablets presented in the order earlier was 4.1, 2.1, 1.9, 2.9, and 9.7 minutes, respectively. The dissolution studies showed that all formulations released 100% of the elemental calcium in simulated gastric fluid in less than 20 minutes. In summary, this study clearly demonstrated that quick disintegrating CC tablets can be formulated without expensive effervescence technology.

UR - http://www.scopus.com/inward/record.url?scp=23144463961&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23144463961&partnerID=8YFLogxK

M3 - Article

C2 - 14727906

AN - SCOPUS:23144463961

VL - 1

JO - AAPS PharmSciTech

JF - AAPS PharmSciTech

SN - 1530-9932

IS - 3

ER -