Evaluation of the stimulant content of dietary supplements marketed as "Ephedra-Free"

Philip J. Gregory

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Background: With the removal of stimulant herb ephedra from the market, dietary supplement manufacturers are coming out with many ephedra-free products. Some of these products appear to simply replace ephedra with stimulants by another name. Objective: To determine the stimulant content of dietary supplements marketed as ephedra-free. Design: Survey of the ingredients of dietary supplements that are stated as "ephedra-free" in the label or promotional material. Results: Out of 36 products marketed as ephedra-free, 32 (89%) contained a methylxanthine such as caffeine or theobromine, 21 (58%) contained the stimulant synephrine, and 20 (56%) contained both a methylxanthine and synephrine. Limitations: The results of this evaluation pertain only to products discovered through Internet and database searching. Conclusions: Most dietary supplement makers have substituted stimulants by a different name for ephedra in their "ephedra-free" products. Patients need to be advised that ephedra-free products are not necessarily stimulant free and may present a significant risk. Copyright (c) by The Haworth Press, Inc. All rights reserved.

Original languageEnglish (US)
Pages (from-to)65-72
Number of pages8
JournalJournal of Herbal Pharmacotherapy
Issue number1
StatePublished - Jul 10 2007

All Science Journal Classification (ASJC) codes

  • Pharmacology


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