Evaluation, treatment, and prevention of vitamin D deficiency: An endocrine society clinical practice guideline

Michael F. Holick, Neil C. Binkley, Heike A. Bischoff-Ferrari, Catherine M. Gordon, David A. Hanley, Robert P. Heaney, M. Hassan Murad, Connie M. Weaver

Research output: Contribution to journalReview article

4310 Citations (Scopus)

Abstract

Objective: The objective was to provide guidelines to clinicians for the evaluation, treatment, and prevention of vitamin D deficiency with an emphasis on the care of patients who are at risk for deficiency. Participants: The Task Force was composed of a Chair, six additional experts, and a methodologist. The Task Force received no corporate funding or remuneration. Consensus Process: Consensus was guided by systematic reviews of evidence and discussions during several conference calls and e-mail communications. The draft prepared by the Task Force was reviewed successively by The Endocrine Society's Clinical Guidelines Subcommittee, Clinical Affairs Core Committee, and cosponsoring associations, and it was posted on The Endocrine Society website for member review. At each stage of review, the Task Force received written comments and incorporated needed changes. Conclusions: Considering that vitamin D deficiency is very commonin all age groups and that few foods contain vitamin D, the Task Force recommended supplementation at suggested daily intake and tolerable upper limit levels, depending on age and clinical circumstances. The Task Force also suggested the measurement of serum 25-hydroxyvitamin D level by a reliable assay as the initial diagnostic test in patients at risk for deficiency. Treatment with either vitamin D2 or vitamin D3 was recommended for deficient patients. At the present time, there is not sufficient evidence to recommend screening individuals who are not at risk for deficiency or to prescribe vitamin D to attain the noncalcemic benefit for cardiovascular protection.

Original languageEnglish
Pages (from-to)1911-1930
Number of pages20
JournalJournal of Clinical Endocrinology and Metabolism
Volume96
Issue number7
DOIs
StatePublished - Jul 1 2011

Fingerprint

Vitamin D Deficiency
Advisory Committees
Practice Guidelines
Vitamin D
Teleconferencing
Ergocalciferols
Cholecalciferol
Consensus
Therapeutics
Guidelines
Remuneration
No-Observed-Adverse-Effect Level
Websites
Assays
Screening
Postal Service
Routine Diagnostic Tests
Communication
Patient Care
Age Groups

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Holick, M. F., Binkley, N. C., Bischoff-Ferrari, H. A., Gordon, C. M., Hanley, D. A., Heaney, R. P., ... Weaver, C. M. (2011). Evaluation, treatment, and prevention of vitamin D deficiency: An endocrine society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism, 96(7), 1911-1930. https://doi.org/10.1210/jc.2011-0385

Evaluation, treatment, and prevention of vitamin D deficiency : An endocrine society clinical practice guideline. / Holick, Michael F.; Binkley, Neil C.; Bischoff-Ferrari, Heike A.; Gordon, Catherine M.; Hanley, David A.; Heaney, Robert P.; Murad, M. Hassan; Weaver, Connie M.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 96, No. 7, 01.07.2011, p. 1911-1930.

Research output: Contribution to journalReview article

Holick, MF, Binkley, NC, Bischoff-Ferrari, HA, Gordon, CM, Hanley, DA, Heaney, RP, Murad, MH & Weaver, CM 2011, 'Evaluation, treatment, and prevention of vitamin D deficiency: An endocrine society clinical practice guideline', Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 7, pp. 1911-1930. https://doi.org/10.1210/jc.2011-0385
Holick, Michael F. ; Binkley, Neil C. ; Bischoff-Ferrari, Heike A. ; Gordon, Catherine M. ; Hanley, David A. ; Heaney, Robert P. ; Murad, M. Hassan ; Weaver, Connie M. / Evaluation, treatment, and prevention of vitamin D deficiency : An endocrine society clinical practice guideline. In: Journal of Clinical Endocrinology and Metabolism. 2011 ; Vol. 96, No. 7. pp. 1911-1930.
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