Evidence-based criteria in the nutritional context

Jeffrey Blumberg, Robert P. Heaney, Michael Huncharek, Theresa Scholl, Meir Stampfer, Reinhold Vieth, Connie M. Weaver, Steven H. Zeisel

Research output: Contribution to journalReview article

102 Citations (Scopus)

Abstract

During the last decade, approaches to evidence-based medicine, with its heavy reliance on the randomized clinical trial (RCT), have been adapted to nutrition science and policy. However, there are distinct differences between the evidence that can be obtained for the testing of drugs using RCTs and those needed for the development of nutrient requirements or dietary guidelines. Although RCTs present one approach toward understanding the efficacy of nutrient interventions, the innate complexities of nutrient actions and interactions cannot always be adequately addressed through any single research design. Because of the limitations inherent in RCTs, particularly of nutrients, it is suggested that nutrient policy decisions will have to be made using the totality of the available evidence. This may mean action at a level of certainty that is different fromwhatwould be needed in the evaluation of drug efficacy. Similarly, it is judged that the level of confidence needed in defining nutrient requirements or dietary recommendations to prevent disease can be different from that needed to make recommendations to treat disease. In brief, advancing evidence-based nutrition will depend upon research approaches that include RCTs but go beyond them. Also necessary to this advance is the assessing, in future human studies, of covariates such as biomarkers of exposure and response, and the archiving of samples for future evaluation by emerging technologies.

Original languageEnglish
Pages (from-to)478-484
Number of pages7
JournalNutrition Reviews
Volume68
Issue number8
DOIs
StatePublished - 2010

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Food
Nutrition Policy
Nutritional Sciences
Nutritional Requirements
Drug Evaluation
Evidence-Based Medicine
Research Design
Randomized Controlled Trials
Biomarkers
Technology
Research
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Medicine(all)

Cite this

Blumberg, J., Heaney, R. P., Huncharek, M., Scholl, T., Stampfer, M., Vieth, R., ... Zeisel, S. H. (2010). Evidence-based criteria in the nutritional context. Nutrition Reviews, 68(8), 478-484. https://doi.org/10.1111/j.1753-4887.2010.00307.x

Evidence-based criteria in the nutritional context. / Blumberg, Jeffrey; Heaney, Robert P.; Huncharek, Michael; Scholl, Theresa; Stampfer, Meir; Vieth, Reinhold; Weaver, Connie M.; Zeisel, Steven H.

In: Nutrition Reviews, Vol. 68, No. 8, 2010, p. 478-484.

Research output: Contribution to journalReview article

Blumberg, J, Heaney, RP, Huncharek, M, Scholl, T, Stampfer, M, Vieth, R, Weaver, CM & Zeisel, SH 2010, 'Evidence-based criteria in the nutritional context', Nutrition Reviews, vol. 68, no. 8, pp. 478-484. https://doi.org/10.1111/j.1753-4887.2010.00307.x
Blumberg J, Heaney RP, Huncharek M, Scholl T, Stampfer M, Vieth R et al. Evidence-based criteria in the nutritional context. Nutrition Reviews. 2010;68(8):478-484. https://doi.org/10.1111/j.1753-4887.2010.00307.x
Blumberg, Jeffrey ; Heaney, Robert P. ; Huncharek, Michael ; Scholl, Theresa ; Stampfer, Meir ; Vieth, Reinhold ; Weaver, Connie M. ; Zeisel, Steven H. / Evidence-based criteria in the nutritional context. In: Nutrition Reviews. 2010 ; Vol. 68, No. 8. pp. 478-484.
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