Evidence for a similar receptor site for binding of [3H]leukotriene E4 and [3H]leukotriene D4 to the guinea-pig crude lung membrane

John B. Cheng, Robert G. Townley

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To determine whether the action of leukotriene E4 is mediated by its cross reaction with leukotriene D4 receptor sites, we compared [3H]leukotriene E4 and [3H]leukotriene D4 binding activities in selected tissues as well as their competition results in the guinea-pig crude lung membrane. We demonstrated good correlation of [3H]leukotriene E4 and [3H]leukotriene D4 binding activities among the tissues studied. A significant correlation was demonstrated between the ability of leukotriene C4, D4 and E4, FPL-55712 and arachidonic acid to inhibit lung [3H]leukotriene E4 and [3H]leukotriene D4 binding. These correlations suggest that leukotriene E4 binds to a site which is similar to or close to the leukotrine D4 receptor.

Original languageEnglish (US)
Pages (from-to)949-954
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number3
StatePublished - Aug 16 1984

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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