Abstract
To determine whether the action of leukotriene E4 is mediated by its cross reaction with leukotriene D4 receptor sites, we compared [3H]leukotriene E4 and [3H]leukotriene D4 binding activities in selected tissues as well as their competition results in the guinea-pig crude lung membrane. We demonstrated good correlation of [3H]leukotriene E4 and [3H]leukotriene D4 binding activities among the tissues studied. A significant correlation was demonstrated between the ability of leukotriene C4, D4 and E4, FPL-55712 and arachidonic acid to inhibit lung [3H]leukotriene E4 and [3H]leukotriene D4 binding. These correlations suggest that leukotriene E4 binds to a site which is similar to or close to the leukotrine D4 receptor.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 949-954 |
| Number of pages | 6 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 122 |
| Issue number | 3 |
| DOIs | |
| State | Published - Aug 16 1984 |
All Science Journal Classification (ASJC) codes
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology
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Cheng, J. B., & Townley, R. G. (1984). Evidence for a similar receptor site for binding of [3H]leukotriene E4 and [3H]leukotriene D4 to the guinea-pig crude lung membrane. Biochemical and Biophysical Research Communications, 122(3), 949-954. https://doi.org/10.1016/0006-291X(84)91183-5