Evidence for aluminum absorption from the gastrointestinal tract and bone deposition by aluminum carbonate ingestion with normal renal function

Robert R. Recker, A. J. Blotcky, J. A. Leffler, E. P. Rack

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

The question of whether aluminum is toxic in patients ingesting large oral loads, either for phosphate binding in renal dialysis or as an antacid for peptic ulcer, has been raised. The permeability of the gut barrier for aluminum has not been established because of the lack of precise analytical techniques. Urine aluminum was measured in this study before and during oral aluminum carbonate loading in six subjects with normal renal function, one of which had peptic ulcer disease and a 25-year history of high oral aluminum ingestion. The analytical procedure involved destructive neutron activation analysis. Aluminum was present in the urine in all instances before loading and rose in every case from 4-fold to 10-fold. Bone aluminum was measured in six autopsy specimens, three dialysis patients, three nondialysis patients, and in an iliac crest biopsy from the peptic ulcer patient who had osteoporosis. The bone biopsy aluminum level in the ulcer patient was intermediate between those of 'normal subjects' and patients on dialysis. These results show that the gut barrier is permeable to heavy aluminum load and suggest that bone aluminum deposition occurs in humans with normal renal function.

Original languageEnglish
Pages (from-to)810-815
Number of pages6
JournalThe Journal of Laboratory and Clinical Medicine
Volume90
Issue number5
StatePublished - 1977

Fingerprint

Carbonates
Aluminum
Gastrointestinal Tract
Bone
Eating
Kidney
Bone and Bones
Dialysis
Peptic Ulcer
Biopsy
Urine
Neutron Activation Analysis
Antacids
Neutron activation analysis
Poisons
Osteoporosis
Ulcer
Renal Dialysis
Autopsy
Permeability

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this

Evidence for aluminum absorption from the gastrointestinal tract and bone deposition by aluminum carbonate ingestion with normal renal function. / Recker, Robert R.; Blotcky, A. J.; Leffler, J. A.; Rack, E. P.

In: The Journal of Laboratory and Clinical Medicine, Vol. 90, No. 5, 1977, p. 810-815.

Research output: Contribution to journalArticle

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