Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala

Ronald T. Riley, Olga Torres, Jorge Matute, Simon G. Gregory, Allison E. Ashley-Koch, Jency L. Showker, Trevor Mitchell, Kenneth A. Voss, Joyce R. Maddox, Janee Gelineau-van Waes

Research output: Contribution to journalArticle

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Abstract

Scope: Fumonisin (FB) occurs in maize and is an inhibitor of ceramide synthase (CerS). We determined the urinary FB1 (UFB1) and sphingoid base 1-phosphate levels in blood from women consuming maize in high and low FB exposure communities in Guatemala. Methods and results: FB1 intake was estimated using the UFB1. Sphinganine 1-phosphate (Sa 1-P), sphingosine 1-phosphate (So 1-P), and the Sa 1-P/So 1-P ratio were determined in blood spots collected on absorbent paper at the same time as urine collection. In the first study, blood spots and urine were collected every 3 months (March 2011 to February 2012) from women living in low (Chimaltenango and Escuintla) and high (Jutiapa) FB exposure communities (1240 total recruits). The UFB1, Sa 1-P/So 1-P ratio, and Sa 1-P/mL in blood spots were significantly higher in the high FB1 intake community compared to the low FB1 intake communities. The results were confirmed in a follow-up study (February 2013) involving 299 women living in low (Sacatepéquez) and high (Santa Rosa and Chiquimula) FB exposure communities. Conclusions: High levels of FB1 intake are correlated with changes in Sa 1-P and the Sa 1-P/So 1-P ratio in human blood in a manner consistent with FB1 inhibition of CerS.

Original languageEnglish
JournalMolecular Nutrition and Food Research
DOIs
StateAccepted/In press - 2015

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Guatemala
Fumonisins
fumonisins
Zea mays
phosphates
Food
corn
sphingosine
blood
Urine Specimen Collection
dihydrosphingosine 1-phosphate
dihydroceramide desaturase
sphingosine N-acyltransferase
urine
Phosphates
Urine
absorbents
sphingosine 1-phosphate
Rosa

All Science Journal Classification (ASJC) codes

  • Food Science
  • Biotechnology

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Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala. / Riley, Ronald T.; Torres, Olga; Matute, Jorge; Gregory, Simon G.; Ashley-Koch, Allison E.; Showker, Jency L.; Mitchell, Trevor; Voss, Kenneth A.; Maddox, Joyce R.; Gelineau-van Waes, Janee.

In: Molecular Nutrition and Food Research, 2015.

Research output: Contribution to journalArticle

Riley, Ronald T. ; Torres, Olga ; Matute, Jorge ; Gregory, Simon G. ; Ashley-Koch, Allison E. ; Showker, Jency L. ; Mitchell, Trevor ; Voss, Kenneth A. ; Maddox, Joyce R. ; Gelineau-van Waes, Janee. / Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala. In: Molecular Nutrition and Food Research. 2015.
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abstract = "Scope: Fumonisin (FB) occurs in maize and is an inhibitor of ceramide synthase (CerS). We determined the urinary FB1 (UFB1) and sphingoid base 1-phosphate levels in blood from women consuming maize in high and low FB exposure communities in Guatemala. Methods and results: FB1 intake was estimated using the UFB1. Sphinganine 1-phosphate (Sa 1-P), sphingosine 1-phosphate (So 1-P), and the Sa 1-P/So 1-P ratio were determined in blood spots collected on absorbent paper at the same time as urine collection. In the first study, blood spots and urine were collected every 3 months (March 2011 to February 2012) from women living in low (Chimaltenango and Escuintla) and high (Jutiapa) FB exposure communities (1240 total recruits). The UFB1, Sa 1-P/So 1-P ratio, and Sa 1-P/mL in blood spots were significantly higher in the high FB1 intake community compared to the low FB1 intake communities. The results were confirmed in a follow-up study (February 2013) involving 299 women living in low (Sacatep{\'e}quez) and high (Santa Rosa and Chiquimula) FB exposure communities. Conclusions: High levels of FB1 intake are correlated with changes in Sa 1-P and the Sa 1-P/So 1-P ratio in human blood in a manner consistent with FB1 inhibition of CerS.",
author = "Riley, {Ronald T.} and Olga Torres and Jorge Matute and Gregory, {Simon G.} and Ashley-Koch, {Allison E.} and Showker, {Jency L.} and Trevor Mitchell and Voss, {Kenneth A.} and Maddox, {Joyce R.} and {Gelineau-van Waes}, Janee",
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AU - Riley, Ronald T.

AU - Torres, Olga

AU - Matute, Jorge

AU - Gregory, Simon G.

AU - Ashley-Koch, Allison E.

AU - Showker, Jency L.

AU - Mitchell, Trevor

AU - Voss, Kenneth A.

AU - Maddox, Joyce R.

AU - Gelineau-van Waes, Janee

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N2 - Scope: Fumonisin (FB) occurs in maize and is an inhibitor of ceramide synthase (CerS). We determined the urinary FB1 (UFB1) and sphingoid base 1-phosphate levels in blood from women consuming maize in high and low FB exposure communities in Guatemala. Methods and results: FB1 intake was estimated using the UFB1. Sphinganine 1-phosphate (Sa 1-P), sphingosine 1-phosphate (So 1-P), and the Sa 1-P/So 1-P ratio were determined in blood spots collected on absorbent paper at the same time as urine collection. In the first study, blood spots and urine were collected every 3 months (March 2011 to February 2012) from women living in low (Chimaltenango and Escuintla) and high (Jutiapa) FB exposure communities (1240 total recruits). The UFB1, Sa 1-P/So 1-P ratio, and Sa 1-P/mL in blood spots were significantly higher in the high FB1 intake community compared to the low FB1 intake communities. The results were confirmed in a follow-up study (February 2013) involving 299 women living in low (Sacatepéquez) and high (Santa Rosa and Chiquimula) FB exposure communities. Conclusions: High levels of FB1 intake are correlated with changes in Sa 1-P and the Sa 1-P/So 1-P ratio in human blood in a manner consistent with FB1 inhibition of CerS.

AB - Scope: Fumonisin (FB) occurs in maize and is an inhibitor of ceramide synthase (CerS). We determined the urinary FB1 (UFB1) and sphingoid base 1-phosphate levels in blood from women consuming maize in high and low FB exposure communities in Guatemala. Methods and results: FB1 intake was estimated using the UFB1. Sphinganine 1-phosphate (Sa 1-P), sphingosine 1-phosphate (So 1-P), and the Sa 1-P/So 1-P ratio were determined in blood spots collected on absorbent paper at the same time as urine collection. In the first study, blood spots and urine were collected every 3 months (March 2011 to February 2012) from women living in low (Chimaltenango and Escuintla) and high (Jutiapa) FB exposure communities (1240 total recruits). The UFB1, Sa 1-P/So 1-P ratio, and Sa 1-P/mL in blood spots were significantly higher in the high FB1 intake community compared to the low FB1 intake communities. The results were confirmed in a follow-up study (February 2013) involving 299 women living in low (Sacatepéquez) and high (Santa Rosa and Chiquimula) FB exposure communities. Conclusions: High levels of FB1 intake are correlated with changes in Sa 1-P and the Sa 1-P/So 1-P ratio in human blood in a manner consistent with FB1 inhibition of CerS.

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