Evidence that neuromedin U may regulate gut motility in reptiles but not in mammals

Charles S. Bockman, Peter W. Abel, James W. Hicks, J. Michael Conlon

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Neuromedin U-8 induced a monophasic and concentration-dependent contraction of intact small intestine from the turtle, Pseudemys scripta, whereas the peptide had no effect upon the motility of rat and guinea pig gut. The maximum response produced by neuromedin U-8 was 56% of that produced by acetylcholine and 62% of that produced by potassium chloride. The potency and maximum response to neuromedin U-8 were unaffected by tetrodotoxin and atropine. The data suggest that neuromedin U may play a role in regulation of gut motility in lower vertebrates but not in mammals.

Original languageEnglish (US)
Pages (from-to)255-257
Number of pages3
JournalEuropean Journal of Pharmacology
Volume171
Issue number2-3
DOIs
StatePublished - Nov 21 1989

All Science Journal Classification (ASJC) codes

  • Pharmacology

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