Evolution and development of the vertebrate ear

B. Fritzsch, Kirk Beisel

Research output: Contribution to journalReview article

54 Citations (Scopus)

Abstract

This review outlines major aspects of development and evolution of the ear, specifically addressing issues of cell fate commitment and the emerging molecular governance of these decisions. Available data support the notion of homology of subsets of mechanosensors across phyla (proprioreceptive mechanosensory neurons in insects, hair cells in vertebrates). It is argued that this conservation is primarily related to the specific transducing environment needed to achieve mechanosensation. Achieving this requires highly conserved transcription factors that regulate the expression of the relevant structural genes for mechanosensory transduction. While conserved at the level of some cell fate assignment genes (atonal and its mammalian homologue), the ear has also radically reorganized its development by implementing genes used for cell fate assignment in other parts of the developing nervous systems (e.g., neurogenin 1) and by evolving novel sets of genes specifically associated with the novel formation of sensory neurons that contact hair cells (neurotrophins and their receptors). Numerous genes have been identified that regulate morphogenesis, but there is only one common feature that emerges at the moment: the ear appears to have co-opted genes from a large variety of other parts of the developing body (forebrain, limbs, kidneys) and establishes, in combination with existing transcription factors, an environment in which those genes govern novel, ear-related morphogenetic aspects. The ear thus represents a unique mix of highly conserved developmental elements combined with co-opted and newly evolved developmental elements.

Original languageEnglish
Pages (from-to)711-721
Number of pages11
JournalBrain Research Bulletin
Volume55
Issue number6
DOIs
StatePublished - 2001

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Ear
Vertebrates
Genes
Cellular Mechanotransduction
Transcription Factors
Nerve Growth Factor Receptors
Sensory Receptor Cells
Prosencephalon
Morphogenesis
Human Body
Nervous System
Insects
Extremities
Kidney
Neurons

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Evolution and development of the vertebrate ear. / Fritzsch, B.; Beisel, Kirk.

In: Brain Research Bulletin, Vol. 55, No. 6, 2001, p. 711-721.

Research output: Contribution to journalReview article

Fritzsch, B. ; Beisel, Kirk. / Evolution and development of the vertebrate ear. In: Brain Research Bulletin. 2001 ; Vol. 55, No. 6. pp. 711-721.
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