Exacerbation of diabetes mellitus by antibodies to exogenous insulin

M. Rendell, R. G. Hamilton, H. M. Drew, N. F. Adkinson

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Three nonobese maturity-onset diabetic patients had worsening hyperglycemia and ketonuria unresponsive to marked increases in dose of beef/pork insulin. In each case, significant cross-reactivity with human insulin of anti-insulin antibodies generated by exogenous insulin therapy was demonstrated by competition experiments using solid phase radioimmunoassay. Normal or near normal levels of endogenous insulin secretion as determined by C-peptide radioimmunoassay were measured in the three cases. The sequence of events that we postulate to explain the initial presentation with severe hyperglycemia in each case begins with a slight deficiency in endogenous insulin reserve. Mild hyperglycemia then led to treatment with beef/pork insulin. The beef component elicited an antibody response that not only bound exogenous insulin, reducing its effectiveness, but also inactivated each patient's endogenous human insulin, provoking an exacerbation of underlying mild diabetes.

Original languageEnglish
Pages (from-to)18-26
Number of pages9
JournalAmerican Journal of the Medical Sciences
Volume282
Issue number1
StatePublished - 1981
Externally publishedYes

Fingerprint

Diabetes Mellitus
Insulin
Antibodies
Hyperglycemia
Radioimmunoassay
Insulin Antibodies
Ketosis
C-Peptide
Antibody Formation
Anti-Idiotypic Antibodies
Red Meat
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Rendell, M., Hamilton, R. G., Drew, H. M., & Adkinson, N. F. (1981). Exacerbation of diabetes mellitus by antibodies to exogenous insulin. American Journal of the Medical Sciences, 282(1), 18-26.

Exacerbation of diabetes mellitus by antibodies to exogenous insulin. / Rendell, M.; Hamilton, R. G.; Drew, H. M.; Adkinson, N. F.

In: American Journal of the Medical Sciences, Vol. 282, No. 1, 1981, p. 18-26.

Research output: Contribution to journalArticle

Rendell, M, Hamilton, RG, Drew, HM & Adkinson, NF 1981, 'Exacerbation of diabetes mellitus by antibodies to exogenous insulin', American Journal of the Medical Sciences, vol. 282, no. 1, pp. 18-26.
Rendell, M. ; Hamilton, R. G. ; Drew, H. M. ; Adkinson, N. F. / Exacerbation of diabetes mellitus by antibodies to exogenous insulin. In: American Journal of the Medical Sciences. 1981 ; Vol. 282, No. 1. pp. 18-26.
@article{95b06ed9511f471b8d95c222d8522f9c,
title = "Exacerbation of diabetes mellitus by antibodies to exogenous insulin",
abstract = "Three nonobese maturity-onset diabetic patients had worsening hyperglycemia and ketonuria unresponsive to marked increases in dose of beef/pork insulin. In each case, significant cross-reactivity with human insulin of anti-insulin antibodies generated by exogenous insulin therapy was demonstrated by competition experiments using solid phase radioimmunoassay. Normal or near normal levels of endogenous insulin secretion as determined by C-peptide radioimmunoassay were measured in the three cases. The sequence of events that we postulate to explain the initial presentation with severe hyperglycemia in each case begins with a slight deficiency in endogenous insulin reserve. Mild hyperglycemia then led to treatment with beef/pork insulin. The beef component elicited an antibody response that not only bound exogenous insulin, reducing its effectiveness, but also inactivated each patient's endogenous human insulin, provoking an exacerbation of underlying mild diabetes.",
author = "M. Rendell and Hamilton, {R. G.} and Drew, {H. M.} and Adkinson, {N. F.}",
year = "1981",
language = "English",
volume = "282",
pages = "18--26",
journal = "American Journal of the Medical Sciences",
issn = "0002-9629",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Exacerbation of diabetes mellitus by antibodies to exogenous insulin

AU - Rendell, M.

AU - Hamilton, R. G.

AU - Drew, H. M.

AU - Adkinson, N. F.

PY - 1981

Y1 - 1981

N2 - Three nonobese maturity-onset diabetic patients had worsening hyperglycemia and ketonuria unresponsive to marked increases in dose of beef/pork insulin. In each case, significant cross-reactivity with human insulin of anti-insulin antibodies generated by exogenous insulin therapy was demonstrated by competition experiments using solid phase radioimmunoassay. Normal or near normal levels of endogenous insulin secretion as determined by C-peptide radioimmunoassay were measured in the three cases. The sequence of events that we postulate to explain the initial presentation with severe hyperglycemia in each case begins with a slight deficiency in endogenous insulin reserve. Mild hyperglycemia then led to treatment with beef/pork insulin. The beef component elicited an antibody response that not only bound exogenous insulin, reducing its effectiveness, but also inactivated each patient's endogenous human insulin, provoking an exacerbation of underlying mild diabetes.

AB - Three nonobese maturity-onset diabetic patients had worsening hyperglycemia and ketonuria unresponsive to marked increases in dose of beef/pork insulin. In each case, significant cross-reactivity with human insulin of anti-insulin antibodies generated by exogenous insulin therapy was demonstrated by competition experiments using solid phase radioimmunoassay. Normal or near normal levels of endogenous insulin secretion as determined by C-peptide radioimmunoassay were measured in the three cases. The sequence of events that we postulate to explain the initial presentation with severe hyperglycemia in each case begins with a slight deficiency in endogenous insulin reserve. Mild hyperglycemia then led to treatment with beef/pork insulin. The beef component elicited an antibody response that not only bound exogenous insulin, reducing its effectiveness, but also inactivated each patient's endogenous human insulin, provoking an exacerbation of underlying mild diabetes.

UR - http://www.scopus.com/inward/record.url?scp=0019480429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019480429&partnerID=8YFLogxK

M3 - Article

C2 - 7270568

AN - SCOPUS:0019480429

VL - 282

SP - 18

EP - 26

JO - American Journal of the Medical Sciences

JF - American Journal of the Medical Sciences

SN - 0002-9629

IS - 1

ER -