Abstract
Background: Aluminum (Al) contamination of parenteral nutrition (PN) solutions remains a concern for long-term PN patients. Al accumulates particularly in bone. Excessive exposure to Al may result in increased Al body burden and impaired bone formation and mineralization, leading to bone disease. Although the U.S. Food and Drug Administration (FDA) has limited Al contamination in large-volume parenteral solutions, small-volume parenterals may still contribute considerable amounts of Al to PN solutions. The goal of this study is to determine whether or not long-term adult PN patients remain at risk for increased bone Al accumulation. Methods: We measured Al accumulation in autopsy bones from 7 patients who had received PN for 2-21 years and compared bone Al levels with those in living control patients undergoing hip or knee replacement. Electrothermal atomic absorption spectrometry was used for bone Al measurements. Results: When compared with bone Al content in controls, markedly elevated Al levels (P
| Original language | English |
|---|---|
| Pages (from-to) | 728-735 |
| Number of pages | 8 |
| Journal | Journal of Parenteral and Enteral Nutrition |
| Volume | 38 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2014 |
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All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Nutrition and Dietetics
- Medicine(all)
Cite this
Excessive aluminum accumulation in the bones of patients on long-term parenteral nutrition : Postmortem analysis by electrothermal atomic absorption spectrometry. / Kruger, Pamela C.; Parsons, Patrick J.; Galusha, Aubrey L.; Morrissette, Michelle; Recker, Robert R.; Howard, Lyn J.
In: Journal of Parenteral and Enteral Nutrition, Vol. 38, No. 6, 2014, p. 728-735.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Excessive aluminum accumulation in the bones of patients on long-term parenteral nutrition
T2 - Postmortem analysis by electrothermal atomic absorption spectrometry
AU - Kruger, Pamela C.
AU - Parsons, Patrick J.
AU - Galusha, Aubrey L.
AU - Morrissette, Michelle
AU - Recker, Robert R.
AU - Howard, Lyn J.
PY - 2014
Y1 - 2014
N2 - Background: Aluminum (Al) contamination of parenteral nutrition (PN) solutions remains a concern for long-term PN patients. Al accumulates particularly in bone. Excessive exposure to Al may result in increased Al body burden and impaired bone formation and mineralization, leading to bone disease. Although the U.S. Food and Drug Administration (FDA) has limited Al contamination in large-volume parenteral solutions, small-volume parenterals may still contribute considerable amounts of Al to PN solutions. The goal of this study is to determine whether or not long-term adult PN patients remain at risk for increased bone Al accumulation. Methods: We measured Al accumulation in autopsy bones from 7 patients who had received PN for 2-21 years and compared bone Al levels with those in living control patients undergoing hip or knee replacement. Electrothermal atomic absorption spectrometry was used for bone Al measurements. Results: When compared with bone Al content in controls, markedly elevated Al levels (P
AB - Background: Aluminum (Al) contamination of parenteral nutrition (PN) solutions remains a concern for long-term PN patients. Al accumulates particularly in bone. Excessive exposure to Al may result in increased Al body burden and impaired bone formation and mineralization, leading to bone disease. Although the U.S. Food and Drug Administration (FDA) has limited Al contamination in large-volume parenteral solutions, small-volume parenterals may still contribute considerable amounts of Al to PN solutions. The goal of this study is to determine whether or not long-term adult PN patients remain at risk for increased bone Al accumulation. Methods: We measured Al accumulation in autopsy bones from 7 patients who had received PN for 2-21 years and compared bone Al levels with those in living control patients undergoing hip or knee replacement. Electrothermal atomic absorption spectrometry was used for bone Al measurements. Results: When compared with bone Al content in controls, markedly elevated Al levels (P
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U2 - 10.1177/0148607113491981
DO - 10.1177/0148607113491981
M3 - Article
VL - 38
SP - 728
EP - 735
JO - Journal of Parenteral and Enteral Nutrition
JF - Journal of Parenteral and Enteral Nutrition
SN - 0148-6071
IS - 6
ER -