Excessive aluminum accumulation in the bones of patients on long-term parenteral nutrition

Postmortem analysis by electrothermal atomic absorption spectrometry

Pamela C. Kruger, Patrick J. Parsons, Aubrey L. Galusha, Michelle Morrissette, Robert R. Recker, Lyn J. Howard

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Aluminum (Al) contamination of parenteral nutrition (PN) solutions remains a concern for long-term PN patients. Al accumulates particularly in bone. Excessive exposure to Al may result in increased Al body burden and impaired bone formation and mineralization, leading to bone disease. Although the U.S. Food and Drug Administration (FDA) has limited Al contamination in large-volume parenteral solutions, small-volume parenterals may still contribute considerable amounts of Al to PN solutions. The goal of this study is to determine whether or not long-term adult PN patients remain at risk for increased bone Al accumulation. Methods: We measured Al accumulation in autopsy bones from 7 patients who had received PN for 2-21 years and compared bone Al levels with those in living control patients undergoing hip or knee replacement. Electrothermal atomic absorption spectrometry was used for bone Al measurements. Results: When compared with bone Al content in controls, markedly elevated Al levels (P

Original languageEnglish
Pages (from-to)728-735
Number of pages8
JournalJournal of Parenteral and Enteral Nutrition
Volume38
Issue number6
DOIs
StatePublished - 2014

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Parenteral Nutrition
Aluminum
Spectrum Analysis
Bone and Bones
Parenteral Nutrition Solutions
Body Burden
Physiologic Calcification
Bone Diseases
United States Food and Drug Administration
Osteogenesis
Hip
Autopsy
Knee

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Medicine(all)

Cite this

Excessive aluminum accumulation in the bones of patients on long-term parenteral nutrition : Postmortem analysis by electrothermal atomic absorption spectrometry. / Kruger, Pamela C.; Parsons, Patrick J.; Galusha, Aubrey L.; Morrissette, Michelle; Recker, Robert R.; Howard, Lyn J.

In: Journal of Parenteral and Enteral Nutrition, Vol. 38, No. 6, 2014, p. 728-735.

Research output: Contribution to journalArticle

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AU - Kruger, Pamela C.

AU - Parsons, Patrick J.

AU - Galusha, Aubrey L.

AU - Morrissette, Michelle

AU - Recker, Robert R.

AU - Howard, Lyn J.

PY - 2014

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AB - Background: Aluminum (Al) contamination of parenteral nutrition (PN) solutions remains a concern for long-term PN patients. Al accumulates particularly in bone. Excessive exposure to Al may result in increased Al body burden and impaired bone formation and mineralization, leading to bone disease. Although the U.S. Food and Drug Administration (FDA) has limited Al contamination in large-volume parenteral solutions, small-volume parenterals may still contribute considerable amounts of Al to PN solutions. The goal of this study is to determine whether or not long-term adult PN patients remain at risk for increased bone Al accumulation. Methods: We measured Al accumulation in autopsy bones from 7 patients who had received PN for 2-21 years and compared bone Al levels with those in living control patients undergoing hip or knee replacement. Electrothermal atomic absorption spectrometry was used for bone Al measurements. Results: When compared with bone Al content in controls, markedly elevated Al levels (P

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