Excretion of sweat and urine pyridinoline crosslinks in healthy controls and subjects with established metabolic bone disease

M. Sarno, L. Sarno, D. Baylink, B. Drinkwater, S. Farley, M. Kleerekoper, R. Lang, J. Lappe, A. Licata, M. McClung, P. Miller, S. Nattrass, R. Recker, E. N. Schwartz, J. R. Tucci, S. Wolf, H. Powell, G. Tjersland, G. Russell Warnick

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Convenient techniques for measuring rates of bone turnover have been developed in recent years with the advent of biochemical markers of bone metabolism. One recent of these techniques is a collection method and quantitative enzyme immunoassay for free pyridinoline crosslinks in human sweat. The concentrations of pyridinoline crosslinks in 5-day sweat collections and first morning void and 24-hour urine collections from healthy subjects and subjects with established metabolic bone disorders were determined. T-scores were higher in the sweat system than in the urine system by up to 10-fold in postmenopausal subjects, women with hyperparathyroidism, and subjects with postmenopausal osteoporosis. For subjects with postmenopausal osteoporosis, receiver-operating characteristic curve analysis yielded areas under the curve of 0.699, 0.629, and 0.520 for sweat pyridinoline, first morning void urine pyridinoline, and 24 hour urine pyridinoline respectively. The areas under the curve of the sweat and first morning void urine measurements were significantly greater (p

Original languageEnglish (US)
Pages (from-to)223-228
Number of pages6
JournalClinical Chemistry and Laboratory Medicine
Volume39
Issue number3
DOIs
StatePublished - May 12 2001

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

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    Sarno, M., Sarno, L., Baylink, D., Drinkwater, B., Farley, S., Kleerekoper, M., Lang, R., Lappe, J., Licata, A., McClung, M., Miller, P., Nattrass, S., Recker, R., Schwartz, E. N., Tucci, J. R., Wolf, S., Powell, H., Tjersland, G., & Russell Warnick, G. (2001). Excretion of sweat and urine pyridinoline crosslinks in healthy controls and subjects with established metabolic bone disease. Clinical Chemistry and Laboratory Medicine, 39(3), 223-228. https://doi.org/10.1515/CCLM.2001.035