Abstract
Convenient techniques for measuring rates of bone turnover have been developed in recent years with the advent of biochemical markers of bone metabolism. One recent of these techniques is a collection method and quantitative enzyme immunoassay for free pyridinoline crosslinks in human sweat. The concentrations of pyridinoline crosslinks in 5-day sweat collections and first morning void and 24-hour urine collections from healthy subjects and subjects with established metabolic bone disorders were determined. T-scores were higher in the sweat system than in the urine system by up to 10-fold in postmenopausal subjects, women with hyperparathyroidism, and subjects with postmenopausal osteoporosis. For subjects with postmenopausal osteoporosis, receiver-operating characteristic curve analysis yielded areas under the curve of 0.699, 0.629, and 0.520 for sweat pyridinoline, first morning void urine pyridinoline, and 24 hour urine pyridinoline respectively. The areas under the curve of the sweat and first morning void urine measurements were significantly greater (p
| Original language | English |
|---|---|
| Pages (from-to) | 223-228 |
| Number of pages | 6 |
| Journal | Clinical Chemistry and Laboratory Medicine |
| Volume | 39 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2001 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Clinical Biochemistry
Cite this
Excretion of sweat and urine pyridinoline crosslinks in healthy controls and subjects with established metabolic bone disease. / Sarno, M.; Sarno, L.; Baylink, D.; Drinkwater, B.; Farley, S.; Kleerekoper, M.; Lang, R.; Lappe, Joan M.; Licata, A.; McClung, M.; Miller, P.; Nattrass, S.; Recker, Robert R.; Schwartz, E. N.; Tucci, J. R.; Wolf, S.; Powell, H.; Tjersland, G.; Russell Warnick, G.
In: Clinical Chemistry and Laboratory Medicine, Vol. 39, No. 3, 2001, p. 223-228.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Excretion of sweat and urine pyridinoline crosslinks in healthy controls and subjects with established metabolic bone disease
AU - Sarno, M.
AU - Sarno, L.
AU - Baylink, D.
AU - Drinkwater, B.
AU - Farley, S.
AU - Kleerekoper, M.
AU - Lang, R.
AU - Lappe, Joan M.
AU - Licata, A.
AU - McClung, M.
AU - Miller, P.
AU - Nattrass, S.
AU - Recker, Robert R.
AU - Schwartz, E. N.
AU - Tucci, J. R.
AU - Wolf, S.
AU - Powell, H.
AU - Tjersland, G.
AU - Russell Warnick, G.
PY - 2001
Y1 - 2001
N2 - Convenient techniques for measuring rates of bone turnover have been developed in recent years with the advent of biochemical markers of bone metabolism. One recent of these techniques is a collection method and quantitative enzyme immunoassay for free pyridinoline crosslinks in human sweat. The concentrations of pyridinoline crosslinks in 5-day sweat collections and first morning void and 24-hour urine collections from healthy subjects and subjects with established metabolic bone disorders were determined. T-scores were higher in the sweat system than in the urine system by up to 10-fold in postmenopausal subjects, women with hyperparathyroidism, and subjects with postmenopausal osteoporosis. For subjects with postmenopausal osteoporosis, receiver-operating characteristic curve analysis yielded areas under the curve of 0.699, 0.629, and 0.520 for sweat pyridinoline, first morning void urine pyridinoline, and 24 hour urine pyridinoline respectively. The areas under the curve of the sweat and first morning void urine measurements were significantly greater (p
AB - Convenient techniques for measuring rates of bone turnover have been developed in recent years with the advent of biochemical markers of bone metabolism. One recent of these techniques is a collection method and quantitative enzyme immunoassay for free pyridinoline crosslinks in human sweat. The concentrations of pyridinoline crosslinks in 5-day sweat collections and first morning void and 24-hour urine collections from healthy subjects and subjects with established metabolic bone disorders were determined. T-scores were higher in the sweat system than in the urine system by up to 10-fold in postmenopausal subjects, women with hyperparathyroidism, and subjects with postmenopausal osteoporosis. For subjects with postmenopausal osteoporosis, receiver-operating characteristic curve analysis yielded areas under the curve of 0.699, 0.629, and 0.520 for sweat pyridinoline, first morning void urine pyridinoline, and 24 hour urine pyridinoline respectively. The areas under the curve of the sweat and first morning void urine measurements were significantly greater (p
UR - http://www.scopus.com/inward/record.url?scp=17744383983&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17744383983&partnerID=8YFLogxK
U2 - 10.1515/CCLM.2001.035
DO - 10.1515/CCLM.2001.035
M3 - Article
C2 - 11350019
AN - SCOPUS:17744383983
VL - 39
SP - 223
EP - 228
JO - Clinical Chemistry and Laboratory Medicine
JF - Clinical Chemistry and Laboratory Medicine
SN - 1434-6621
IS - 3
ER -