Abstract
MicroRNAs (miRNAs), small non-coding regulatory RNAs that regulate gene expression at the post-transcriptional level, are master regulators of a wide array of cellular processes. Altered miRNA expression could be a determinant of disease development and/or progression and manipulation of miRNA expression represents a potential avenue of therapy. Exosomes are cell-derived extracellular vesicles that promote cell-cell communication and immunoregulatory functions. These "bioactive vesicles" shuttle various molecules, including miRNAs, to recipient cells. Inappropriate release of miRNAs from exosomes may cause significant alterations in biological pathways that affect disease development, supporting the concept that miRNA-containing exosomes could serve as targeted therapies for particular diseases. This review briefly summarizes recent advances in the biology, function, and therapeutic potential of exosomal miRNAs.
| Original language | English |
|---|---|
| Article number | Article 56 |
| Journal | Frontiers in Genetics |
| Volume | 3 |
| Issue number | APR |
| DOIs | |
| State | Published - 2012 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Genetics
- Molecular Medicine
- Genetics(clinical)
Cite this
Exosomal miRNAs : Biological properties and therapeutic potential. / Hu, Guoku; Drescher, Kristen M.; Chen, Xian-Ming.
In: Frontiers in Genetics, Vol. 3, No. APR, Article 56, 2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Exosomal miRNAs
T2 - Biological properties and therapeutic potential
AU - Hu, Guoku
AU - Drescher, Kristen M.
AU - Chen, Xian-Ming
PY - 2012
Y1 - 2012
N2 - MicroRNAs (miRNAs), small non-coding regulatory RNAs that regulate gene expression at the post-transcriptional level, are master regulators of a wide array of cellular processes. Altered miRNA expression could be a determinant of disease development and/or progression and manipulation of miRNA expression represents a potential avenue of therapy. Exosomes are cell-derived extracellular vesicles that promote cell-cell communication and immunoregulatory functions. These "bioactive vesicles" shuttle various molecules, including miRNAs, to recipient cells. Inappropriate release of miRNAs from exosomes may cause significant alterations in biological pathways that affect disease development, supporting the concept that miRNA-containing exosomes could serve as targeted therapies for particular diseases. This review briefly summarizes recent advances in the biology, function, and therapeutic potential of exosomal miRNAs.
AB - MicroRNAs (miRNAs), small non-coding regulatory RNAs that regulate gene expression at the post-transcriptional level, are master regulators of a wide array of cellular processes. Altered miRNA expression could be a determinant of disease development and/or progression and manipulation of miRNA expression represents a potential avenue of therapy. Exosomes are cell-derived extracellular vesicles that promote cell-cell communication and immunoregulatory functions. These "bioactive vesicles" shuttle various molecules, including miRNAs, to recipient cells. Inappropriate release of miRNAs from exosomes may cause significant alterations in biological pathways that affect disease development, supporting the concept that miRNA-containing exosomes could serve as targeted therapies for particular diseases. This review briefly summarizes recent advances in the biology, function, and therapeutic potential of exosomal miRNAs.
UR - http://www.scopus.com/inward/record.url?scp=84869212180&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84869212180&partnerID=8YFLogxK
U2 - 10.3389/fgene.2012.00056
DO - 10.3389/fgene.2012.00056
M3 - Article
C2 - 22529849
AN - SCOPUS:84869212180
VL - 3
JO - Frontiers in Genetics
JF - Frontiers in Genetics
SN - 1664-8021
IS - APR
M1 - Article 56
ER -