Experimental Chronic Wasting Disease (CWD) in the Ferret

C. J. Sigurdson, C. K. Mathiason, M. R. Perrott, G. A. Eliason, T. R. Spraker, M. Glatzel, G. Manco, Jason C. Bartz, M. W. Miller, E. A. Hoover

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Chronic wasting disease (CWD), a prion disease of North American deer, elk and moose, affects both free-ranging and captive cervids. The potential host range for CWD remains uncertain. The susceptibility of the ferret to CWD was examined experimentally by administering infectious brain material by the intracerebral (IC) or oral (PO) route. Between 15 and 20 months after IC inoculation, ferrets developed neurological signs consistent with prion disease, including polyphagia, somnolence, piloerection, lordosis and ataxia. Upon first sub-passage of ferret-adapted CWD, the incubation period decreased to 5 months. Spongiform change in the neuropil was most marked in the basal ganglia, thalamus, midbrain and pons. The deposition of PrPCWD was granular and was occasionally closely associated with, or localized within, neurons. There were no plaque-like or perivascular PrP aggregates as seen in CWD-infected cervids. In western blots, the PrPCWD glycoform profile resembled that of CWD in deer, typified by a dominant diglycosylated glycoform. CWD disease in ferrets followed IC but not PO inoculation, even after 31 months of observation. These findings indicate that CWD-infected ferrets share microscopical and biochemical features of CWD in cervids, but appear to be relatively resistant to oral infection by primary CWD inoculum of deer origin.

Original languageEnglish
Pages (from-to)189-196
Number of pages8
JournalJournal of Comparative Pathology
Volume138
Issue number4
DOIs
StatePublished - May 2008

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Chronic Wasting Disease
chronic wasting disease
Ferrets
ferrets
Deer
deer
Prion Diseases
prion diseases
mouth
Piloerection
brain
Lordosis
Hyperphagia
Neuropil
thalamus
Pons
Alces alces
elks
Host Specificity
Ataxia

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology

Cite this

Sigurdson, C. J., Mathiason, C. K., Perrott, M. R., Eliason, G. A., Spraker, T. R., Glatzel, M., ... Hoover, E. A. (2008). Experimental Chronic Wasting Disease (CWD) in the Ferret. Journal of Comparative Pathology, 138(4), 189-196. https://doi.org/10.1016/j.jcpa.2008.01.004

Experimental Chronic Wasting Disease (CWD) in the Ferret. / Sigurdson, C. J.; Mathiason, C. K.; Perrott, M. R.; Eliason, G. A.; Spraker, T. R.; Glatzel, M.; Manco, G.; Bartz, Jason C.; Miller, M. W.; Hoover, E. A.

In: Journal of Comparative Pathology, Vol. 138, No. 4, 05.2008, p. 189-196.

Research output: Contribution to journalArticle

Sigurdson, CJ, Mathiason, CK, Perrott, MR, Eliason, GA, Spraker, TR, Glatzel, M, Manco, G, Bartz, JC, Miller, MW & Hoover, EA 2008, 'Experimental Chronic Wasting Disease (CWD) in the Ferret', Journal of Comparative Pathology, vol. 138, no. 4, pp. 189-196. https://doi.org/10.1016/j.jcpa.2008.01.004
Sigurdson CJ, Mathiason CK, Perrott MR, Eliason GA, Spraker TR, Glatzel M et al. Experimental Chronic Wasting Disease (CWD) in the Ferret. Journal of Comparative Pathology. 2008 May;138(4):189-196. https://doi.org/10.1016/j.jcpa.2008.01.004
Sigurdson, C. J. ; Mathiason, C. K. ; Perrott, M. R. ; Eliason, G. A. ; Spraker, T. R. ; Glatzel, M. ; Manco, G. ; Bartz, Jason C. ; Miller, M. W. ; Hoover, E. A. / Experimental Chronic Wasting Disease (CWD) in the Ferret. In: Journal of Comparative Pathology. 2008 ; Vol. 138, No. 4. pp. 189-196.
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