Abstract
An animal model for cobalt-induced cardiac disease is reported. Cardiac lesions involving the pericardium, the myocardium, and the endocardium were produced in guinea pigs by oral administration of 20 mg. per kilogram per day of cobalt. Light and electron-microscopic features and electrocardiographic findings of experimentally produced cobalt lesions were strikingly similar to those observed in Quebec beer drinkers' cardiomyopathy. Addition of 2 Gm. of ethyl alcohol to the cobalt regimen failed to modify the incidence or the severity of the disease.
| Original language | English |
|---|---|
| Pages (from-to) | 532-543 |
| Number of pages | 12 |
| Journal | American Heart Journal |
| Volume | 80 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1970 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
Cite this
Experimental cobalt cardiomyopathy. / Mohiuddin, Syed M.; Taskar, P. K.; Rheault, Michel; Roy, Paul E.; Chenard, Jacques; Morin, Yves.
In: American Heart Journal, Vol. 80, No. 4, 1970, p. 532-543.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Experimental cobalt cardiomyopathy
AU - Mohiuddin, Syed M.
AU - Taskar, P. K.
AU - Rheault, Michel
AU - Roy, Paul E.
AU - Chenard, Jacques
AU - Morin, Yves
PY - 1970
Y1 - 1970
N2 - An animal model for cobalt-induced cardiac disease is reported. Cardiac lesions involving the pericardium, the myocardium, and the endocardium were produced in guinea pigs by oral administration of 20 mg. per kilogram per day of cobalt. Light and electron-microscopic features and electrocardiographic findings of experimentally produced cobalt lesions were strikingly similar to those observed in Quebec beer drinkers' cardiomyopathy. Addition of 2 Gm. of ethyl alcohol to the cobalt regimen failed to modify the incidence or the severity of the disease.
AB - An animal model for cobalt-induced cardiac disease is reported. Cardiac lesions involving the pericardium, the myocardium, and the endocardium were produced in guinea pigs by oral administration of 20 mg. per kilogram per day of cobalt. Light and electron-microscopic features and electrocardiographic findings of experimentally produced cobalt lesions were strikingly similar to those observed in Quebec beer drinkers' cardiomyopathy. Addition of 2 Gm. of ethyl alcohol to the cobalt regimen failed to modify the incidence or the severity of the disease.
UR - http://www.scopus.com/inward/record.url?scp=0014866291&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0014866291&partnerID=8YFLogxK
U2 - 10.1016/0002-8703(70)90202-4
DO - 10.1016/0002-8703(70)90202-4
M3 - Article
VL - 80
SP - 532
EP - 543
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 4
ER -