Experimental cobalt cardiomyopathy

Syed M. Mohiuddin, P. K. Taskar, Michel Rheault, Paul E. Roy, Jacques Chenard, Yves Morin

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

An animal model for cobalt-induced cardiac disease is reported. Cardiac lesions involving the pericardium, the myocardium, and the endocardium were produced in guinea pigs by oral administration of 20 mg. per kilogram per day of cobalt. Light and electron-microscopic features and electrocardiographic findings of experimentally produced cobalt lesions were strikingly similar to those observed in Quebec beer drinkers' cardiomyopathy. Addition of 2 Gm. of ethyl alcohol to the cobalt regimen failed to modify the incidence or the severity of the disease.

Original languageEnglish
Pages (from-to)532-543
Number of pages12
JournalAmerican Heart Journal
Volume80
Issue number4
DOIs
StatePublished - 1970
Externally publishedYes

Fingerprint

Cobalt
Cardiomyopathies
Endocardium
Quebec
Pericardium
Oral Administration
Heart Diseases
Myocardium
Guinea Pigs
Ethanol
Animal Models
Electrons
Light
Incidence

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Mohiuddin, S. M., Taskar, P. K., Rheault, M., Roy, P. E., Chenard, J., & Morin, Y. (1970). Experimental cobalt cardiomyopathy. American Heart Journal, 80(4), 532-543. https://doi.org/10.1016/0002-8703(70)90202-4

Experimental cobalt cardiomyopathy. / Mohiuddin, Syed M.; Taskar, P. K.; Rheault, Michel; Roy, Paul E.; Chenard, Jacques; Morin, Yves.

In: American Heart Journal, Vol. 80, No. 4, 1970, p. 532-543.

Research output: Contribution to journalArticle

Mohiuddin, SM, Taskar, PK, Rheault, M, Roy, PE, Chenard, J & Morin, Y 1970, 'Experimental cobalt cardiomyopathy', American Heart Journal, vol. 80, no. 4, pp. 532-543. https://doi.org/10.1016/0002-8703(70)90202-4
Mohiuddin SM, Taskar PK, Rheault M, Roy PE, Chenard J, Morin Y. Experimental cobalt cardiomyopathy. American Heart Journal. 1970;80(4):532-543. https://doi.org/10.1016/0002-8703(70)90202-4
Mohiuddin, Syed M. ; Taskar, P. K. ; Rheault, Michel ; Roy, Paul E. ; Chenard, Jacques ; Morin, Yves. / Experimental cobalt cardiomyopathy. In: American Heart Journal. 1970 ; Vol. 80, No. 4. pp. 532-543.
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