Experimental cobalt cardiomyopathy

Syed M. Mohiuddin, P. K. Taskar, Michel Rheault, Paul E. Roy, Jacques Chenard, Yves Morin

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

An animal model for cobalt-induced cardiac disease is reported. Cardiac lesions involving the pericardium, the myocardium, and the endocardium were produced in guinea pigs by oral administration of 20 mg. per kilogram per day of cobalt. Light and electron-microscopic features and electrocardiographic findings of experimentally produced cobalt lesions were strikingly similar to those observed in Quebec beer drinkers' cardiomyopathy. Addition of 2 Gm. of ethyl alcohol to the cobalt regimen failed to modify the incidence or the severity of the disease.

Original languageEnglish (US)
Pages (from-to)532-543
Number of pages12
JournalAmerican Heart Journal
Volume80
Issue number4
DOIs
StatePublished - Oct 1970
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Mohiuddin, S. M., Taskar, P. K., Rheault, M., Roy, P. E., Chenard, J., & Morin, Y. (1970). Experimental cobalt cardiomyopathy. American Heart Journal, 80(4), 532-543. https://doi.org/10.1016/0002-8703(70)90202-4