Experimental cobalt cardiomyopathy

Syed M. Mohiuddin; P. K. Taskar; Michel Rheault; Paul E. Roy; Jacques Chenard; Yves Morin

doi:10.1016/0002-8703(70)90202-4

Experimental cobalt cardiomyopathy

Syed M. Mohiuddin, P. K. Taskar, Michel Rheault, Paul E. Roy, Jacques Chenard, Yves Morin

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31 Scopus citations

Abstract

An animal model for cobalt-induced cardiac disease is reported. Cardiac lesions involving the pericardium, the myocardium, and the endocardium were produced in guinea pigs by oral administration of 20 mg. per kilogram per day of cobalt. Light and electron-microscopic features and electrocardiographic findings of experimentally produced cobalt lesions were strikingly similar to those observed in Quebec beer drinkers' cardiomyopathy. Addition of 2 Gm. of ethyl alcohol to the cobalt regimen failed to modify the incidence or the severity of the disease.

Original language	English (US)
Pages (from-to)	532-543
Number of pages	12
Journal	American Heart Journal
Volume	80
Issue number	4
DOIs	https://doi.org/10.1016/0002-8703(70)90202-4
State	Published - Oct 1970
Externally published	Yes

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All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

Cite this

Mohiuddin, S. M., Taskar, P. K., Rheault, M., Roy, P. E., Chenard, J., & Morin, Y. (1970). Experimental cobalt cardiomyopathy. American Heart Journal, 80(4), 532-543. https://doi.org/10.1016/0002-8703(70)90202-4

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AU - Morin, Yves

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AB - An animal model for cobalt-induced cardiac disease is reported. Cardiac lesions involving the pericardium, the myocardium, and the endocardium were produced in guinea pigs by oral administration of 20 mg. per kilogram per day of cobalt. Light and electron-microscopic features and electrocardiographic findings of experimentally produced cobalt lesions were strikingly similar to those observed in Quebec beer drinkers' cardiomyopathy. Addition of 2 Gm. of ethyl alcohol to the cobalt regimen failed to modify the incidence or the severity of the disease.

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10.1016/0002-8703(70)90202-4