Experimental cobalt cardiomyopathy

Syed M. Mohiuddin; P. K. Taskar; Michel Rheault; Paul E. Roy; Jacques Chenard; Yves Morin

doi:10.1016/0002-8703(70)90202-4

Experimental cobalt cardiomyopathy

Syed M. Mohiuddin, P. K. Taskar, Michel Rheault, Paul E. Roy, Jacques Chenard, Yves Morin

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

An animal model for cobalt-induced cardiac disease is reported. Cardiac lesions involving the pericardium, the myocardium, and the endocardium were produced in guinea pigs by oral administration of 20 mg. per kilogram per day of cobalt. Light and electron-microscopic features and electrocardiographic findings of experimentally produced cobalt lesions were strikingly similar to those observed in Quebec beer drinkers' cardiomyopathy. Addition of 2 Gm. of ethyl alcohol to the cobalt regimen failed to modify the incidence or the severity of the disease.

Original language	English (US)
Pages (from-to)	532-543
Number of pages	12
Journal	American Heart Journal
Volume	80
Issue number	4
DOIs	https://doi.org/10.1016/0002-8703(70)90202-4
State	Published - Oct 1970
Externally published	Yes

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

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10.1016/0002-8703(70)90202-4

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title = "Experimental cobalt cardiomyopathy",

abstract = "An animal model for cobalt-induced cardiac disease is reported. Cardiac lesions involving the pericardium, the myocardium, and the endocardium were produced in guinea pigs by oral administration of 20 mg. per kilogram per day of cobalt. Light and electron-microscopic features and electrocardiographic findings of experimentally produced cobalt lesions were strikingly similar to those observed in Quebec beer drinkers' cardiomyopathy. Addition of 2 Gm. of ethyl alcohol to the cobalt regimen failed to modify the incidence or the severity of the disease.",

author = "Mohiuddin, {Syed M.} and Taskar, {P. K.} and Michel Rheault and Roy, {Paul E.} and Jacques Chenard and Yves Morin",

note = "Funding Information: From the Institut de Cardiolosie de Quebec. Lava1 Cnivereity, This work was supported by research grants from the Medical Foundation. Received for publication Feb. 2, 1970. Reprint requests to: Dr. I{\textquoteright}ves Morin. Institut de Cardiologie Canada. *This work was presented in part at the Annual Meeting of the Canadian Ontario. Canada, Jan. 16 to 17, 1968.",

year = "1970",

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doi = "10.1016/0002-8703(70)90202-4",

language = "English (US)",

volume = "80",

pages = "532--543",

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TY - JOUR

T1 - Experimental cobalt cardiomyopathy

AU - Mohiuddin, Syed M.

AU - Taskar, P. K.

AU - Rheault, Michel

AU - Roy, Paul E.

AU - Chenard, Jacques

AU - Morin, Yves

N1 - Funding Information: From the Institut de Cardiolosie de Quebec. Lava1 Cnivereity, This work was supported by research grants from the Medical Foundation. Received for publication Feb. 2, 1970. Reprint requests to: Dr. I’ves Morin. Institut de Cardiologie Canada. *This work was presented in part at the Annual Meeting of the Canadian Ontario. Canada, Jan. 16 to 17, 1968.

PY - 1970/10

Y1 - 1970/10

N2 - An animal model for cobalt-induced cardiac disease is reported. Cardiac lesions involving the pericardium, the myocardium, and the endocardium were produced in guinea pigs by oral administration of 20 mg. per kilogram per day of cobalt. Light and electron-microscopic features and electrocardiographic findings of experimentally produced cobalt lesions were strikingly similar to those observed in Quebec beer drinkers' cardiomyopathy. Addition of 2 Gm. of ethyl alcohol to the cobalt regimen failed to modify the incidence or the severity of the disease.

AB - An animal model for cobalt-induced cardiac disease is reported. Cardiac lesions involving the pericardium, the myocardium, and the endocardium were produced in guinea pigs by oral administration of 20 mg. per kilogram per day of cobalt. Light and electron-microscopic features and electrocardiographic findings of experimentally produced cobalt lesions were strikingly similar to those observed in Quebec beer drinkers' cardiomyopathy. Addition of 2 Gm. of ethyl alcohol to the cobalt regimen failed to modify the incidence or the severity of the disease.

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Experimental cobalt cardiomyopathy

Abstract

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