Expression of intestinal MUC17 membrane-bound mucin in inflammatory and neoplastic diseases of the colon

Shantibhusan Senapati, Samuel B. Ho, Poonam K Sharma, Srustidhar Das, Subhankar Chakraborty, Sukhwinder Kaur, Gloria Niehans, Surinder K. Batra

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Abstract

Aim: To determine the cellular location and expression of MUC17 mucin in specimens of normal, inflamed and neoplastic colon. Methods: Immunohistochemical analysis of human surgical resection specimens (n=106) was performed with a specific antibody to the MUC17 apomucin protein. A semi-quantitative scoring system was used to measure MUC17 expression. In various colon cancer cell lines, the MUC17 expression was examined by immunoblot analysis and normal RT-PCR. Results: MUC17 was highly expressed on the surface epithelium and crypts of colonic mucosa. In contrast, the expression of MUC17 was significantly decreased in colonic mucosa of chronic ulcerative colitis (p

Original languageEnglish
Pages (from-to)702-707
Number of pages6
JournalJournal of Clinical Pathology - Clinical Molecular Pathology
Volume63
Issue number8
DOIs
StatePublished - Aug 2010

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All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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