TY - JOUR
T1 - Expression of intestinal MUC17 membrane-bound mucin in inflammatory and neoplastic diseases of the colon
AU - Senapati, Shantibhusan
AU - Ho, Samuel B.
AU - Sharma, Poonam
AU - Das, Srustidhar
AU - Chakraborty, Subhankar
AU - Kaur, Sukhwinder
AU - Niehans, Gloria
AU - Batra, Surinder K.
PY - 2010/8
Y1 - 2010/8
N2 - Aim: To determine the cellular location and expression of MUC17 mucin in specimens of normal, inflamed and neoplastic colon. Methods: Immunohistochemical analysis of human surgical resection specimens (n=106) was performed with a specific antibody to the MUC17 apomucin protein. A semi-quantitative scoring system was used to measure MUC17 expression. In various colon cancer cell lines, the MUC17 expression was examined by immunoblot analysis and normal RT-PCR. Results: MUC17 was highly expressed on the surface epithelium and crypts of colonic mucosa. In contrast, the expression of MUC17 was significantly decreased in colonic mucosa of chronic ulcerative colitis (p
AB - Aim: To determine the cellular location and expression of MUC17 mucin in specimens of normal, inflamed and neoplastic colon. Methods: Immunohistochemical analysis of human surgical resection specimens (n=106) was performed with a specific antibody to the MUC17 apomucin protein. A semi-quantitative scoring system was used to measure MUC17 expression. In various colon cancer cell lines, the MUC17 expression was examined by immunoblot analysis and normal RT-PCR. Results: MUC17 was highly expressed on the surface epithelium and crypts of colonic mucosa. In contrast, the expression of MUC17 was significantly decreased in colonic mucosa of chronic ulcerative colitis (p
UR - http://www.scopus.com/inward/record.url?scp=77955722731&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955722731&partnerID=8YFLogxK
U2 - 10.1136/jcp.2010.078717
DO - 10.1136/jcp.2010.078717
M3 - Article
C2 - 20702471
AN - SCOPUS:77955722731
VL - 63
SP - 702
EP - 707
JO - Molecular pathology : MP
JF - Molecular pathology : MP
SN - 0021-9746
IS - 8
ER -