Expression of potassium channels in gerbil outer hair cells during development does not require neural induction

David Z.Z. He; Peter Dallos

doi:10.1016/S0165-3806(97)00120-X

Expression of potassium channels in gerbil outer hair cells during development does not require neural induction

David Z.Z. He, Peter Dallos

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Mammalian outer hair cells (OHCs) contain Ca and K channels in their synaptic pole. We questioned if the ontogeny of potassium currents of OHCs depends on the neural induction of early afferent contact. By recording whole-cell currents of OHCs grown in organotypic cultures deprived of afferent innervation, we show that a Ca-activated K channel is expressed in these cells, suggesting that the ontogeny of the K channel is an intrinsic process.

Original language	English (US)
Pages (from-to)	95-97
Number of pages	3
Journal	Developmental Brain Research
Volume	103
Issue number	1
DOIs	https://doi.org/10.1016/S0165-3806(97)00120-X
State	Published - Oct 20 1997
Externally published	Yes

All Science Journal Classification (ASJC) codes

Developmental Neuroscience
Developmental Biology

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10.1016/S0165-3806(97)00120-X

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title = "Expression of potassium channels in gerbil outer hair cells during development does not require neural induction",

abstract = "Mammalian outer hair cells (OHCs) contain Ca and K channels in their synaptic pole. We questioned if the ontogeny of potassium currents of OHCs depends on the neural induction of early afferent contact. By recording whole-cell currents of OHCs grown in organotypic cultures deprived of afferent innervation, we show that a Ca-activated K channel is expressed in these cells, suggesting that the ontogeny of the K channel is an intrinsic process.",

author = "He, {David Z.Z.} and Peter Dallos",

note = "Funding Information: We wish to thank Drs. Xi Lin and Xintian Hu and Mary Ann Cheatham for technical assistance and helpful discussions. This work has been supported by NIH grant DC 00708 from the National Institute of Deafness and Other Communication Disorders to P.D.",

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AU - He, David Z.Z.

AU - Dallos, Peter

N1 - Funding Information: We wish to thank Drs. Xi Lin and Xintian Hu and Mary Ann Cheatham for technical assistance and helpful discussions. This work has been supported by NIH grant DC 00708 from the National Institute of Deafness and Other Communication Disorders to P.D.

PY - 1997/10/20

Y1 - 1997/10/20

N2 - Mammalian outer hair cells (OHCs) contain Ca and K channels in their synaptic pole. We questioned if the ontogeny of potassium currents of OHCs depends on the neural induction of early afferent contact. By recording whole-cell currents of OHCs grown in organotypic cultures deprived of afferent innervation, we show that a Ca-activated K channel is expressed in these cells, suggesting that the ontogeny of the K channel is an intrinsic process.

AB - Mammalian outer hair cells (OHCs) contain Ca and K channels in their synaptic pole. We questioned if the ontogeny of potassium currents of OHCs depends on the neural induction of early afferent contact. By recording whole-cell currents of OHCs grown in organotypic cultures deprived of afferent innervation, we show that a Ca-activated K channel is expressed in these cells, suggesting that the ontogeny of the K channel is an intrinsic process.

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JF - Developmental Brain Research

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Expression of potassium channels in gerbil outer hair cells during development does not require neural induction

Abstract

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