Extracolonic cancer in hereditary nonpolyposis colorectal cancer

P. Watson, Henry T. Lynch

Research output: Contribution to journalArticle

633 Citations (Scopus)

Abstract

Background. It has been hypothesized that in some but not all families with hereditary nonpolyposis colorectal cancer (HNPCC) there is a high risk of certain cancers other than colon cancer. Methods. The authors compared the observed frequency of cancer at specific sites in more than 1300 high-risk members of 23 kindreds with HNPCC with expectations based on general population incidence and evaluated the hypothesis that there was heterogeneity in cancer frequency among families. Results. The authors observed significantly increased numbers of cancers of the stomach, small intestine, upper urologic tract (renal pelvis and ureter), and ovary. No excess was seen in other cancer types that have been associated previously with HNPCC, including cancer of the breast, pancreas, and urinary bladder. Significant heterogeneity among families was observed in the frequencies of endometrial, ovarian, and upper urologic system cancer. Conclusion. In addition to early onset cancers of the colorectum, HNPCC family members are at increased risk for cancers of other gastrointestinal tract organs, and, especially in some families, cancers of the upper urologic and female genital tract.

Original languageEnglish
Pages (from-to)677-685
Number of pages9
JournalCancer
Volume71
Issue number3
DOIs
StatePublished - 1993

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Hereditary Nonpolyposis Colorectal Neoplasms
Urologic Neoplasms
Neoplasms
Colonic Neoplasms
Kidney Pelvis
Gastrointestinal Neoplasms
Ureter
Pancreatic Neoplasms
Small Intestine
Stomach Neoplasms
Ovary
Urinary Bladder
Breast Neoplasms
Incidence
Population

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

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Extracolonic cancer in hereditary nonpolyposis colorectal cancer. / Watson, P.; Lynch, Henry T.

In: Cancer, Vol. 71, No. 3, 1993, p. 677-685.

Research output: Contribution to journalArticle

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