Abstract
OBJECTIVE: Our purpose was to describe histologically verified endometrial carcinoma and other cancer types manifested through three generations in a pedigree, where these findings do not fit any classic hereditary cancer syndrome. STUDY DESIGN: Our family study protocol used, detailed patient interviews whenever possible and questionnaires with permission forms that, when signed, enabled retrieval of pertinent medical-genetic and pathologic, study documents. RESULTS: Endometrial carcinoma was histologically verified in five women through three consecutive generations. The triad of obesity, hypertension, and diabetes mellitus was not observed. Primary carcinomas of both the endometrium and ovary and endometrium and lymphoma were documented in two relatives in the direct genetic lineage of the pedigree. CONCLUSION: An aggregation of endometrial carcinoma in families, even when classic hereditary cancer syndrome identification is lacking, nevertheless merits surveillance and management strategies targeted to putative-high-risk family members.
| Original language | English |
|---|---|
| Pages (from-to) | 24-27 |
| Number of pages | 4 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 171 |
| Issue number | 1 |
| State | Published - Jul 1994 |
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All Science Journal Classification (ASJC) codes
- Obstetrics and Gynecology
- Medicine(all)
Cite this
Familial aggregation of carcinoma of the endometrium. / Lynch, Henry T.; Lynch, Jane; Conway, Theresa; Watson, Patrice; Coleman, Robert L.
In: American Journal of Obstetrics and Gynecology, Vol. 171, No. 1, 07.1994, p. 24-27.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Familial aggregation of carcinoma of the endometrium
AU - Lynch, Henry T.
AU - Lynch, Jane
AU - Conway, Theresa
AU - Watson, Patrice
AU - Coleman, Robert L.
PY - 1994/7
Y1 - 1994/7
N2 - OBJECTIVE: Our purpose was to describe histologically verified endometrial carcinoma and other cancer types manifested through three generations in a pedigree, where these findings do not fit any classic hereditary cancer syndrome. STUDY DESIGN: Our family study protocol used, detailed patient interviews whenever possible and questionnaires with permission forms that, when signed, enabled retrieval of pertinent medical-genetic and pathologic, study documents. RESULTS: Endometrial carcinoma was histologically verified in five women through three consecutive generations. The triad of obesity, hypertension, and diabetes mellitus was not observed. Primary carcinomas of both the endometrium and ovary and endometrium and lymphoma were documented in two relatives in the direct genetic lineage of the pedigree. CONCLUSION: An aggregation of endometrial carcinoma in families, even when classic hereditary cancer syndrome identification is lacking, nevertheless merits surveillance and management strategies targeted to putative-high-risk family members.
AB - OBJECTIVE: Our purpose was to describe histologically verified endometrial carcinoma and other cancer types manifested through three generations in a pedigree, where these findings do not fit any classic hereditary cancer syndrome. STUDY DESIGN: Our family study protocol used, detailed patient interviews whenever possible and questionnaires with permission forms that, when signed, enabled retrieval of pertinent medical-genetic and pathologic, study documents. RESULTS: Endometrial carcinoma was histologically verified in five women through three consecutive generations. The triad of obesity, hypertension, and diabetes mellitus was not observed. Primary carcinomas of both the endometrium and ovary and endometrium and lymphoma were documented in two relatives in the direct genetic lineage of the pedigree. CONCLUSION: An aggregation of endometrial carcinoma in families, even when classic hereditary cancer syndrome identification is lacking, nevertheless merits surveillance and management strategies targeted to putative-high-risk family members.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027965160&partnerID=8YFLogxK
M3 - Article
C2 - 8030707
AN - SCOPUS:0027965160
VL - 171
SP - 24
EP - 27
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 1
ER -