Familial association of breast/ovarian carcinoma

Henry T. Lynch, R. E. Harris, H. A. Guirgis, K. Maloney, L. L. Carmody, J. F. Lynch

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

Twelve pedigrees which show clustering of breast/ovarian cancer among female relatives are analyzed from a medical-genetic standpoint. The significant linear decline in estimates of cumulative breast/ovarian cancer risk to females with diminishing genetic relationship to probands and index cases, plus the lack of excessive site-specific cancer risk to male relatives, supports a sex-limited genetic etiology. Breast/ovarian cancer typically occurred at an early age (x = 50.6 years) in these kindreds compared to the general population, which is another characteristic of hereditary cancer. Examples of apparent mother to daughter and father to daughter genetic transmission of proclivity for breast/ovarian carcinoma were prevalent in the 12 pedigrees. Excluding probands and index cases, the estimated cumulative risk of breast/ovarian cancer to female progeny of affected mothers was 46% for the age interval 20-80 years, suggesting that affected mothers in the pedigrees are transmitting a deleterious cancer-predisposing gene to one-half of their daughters. Eight sibships involving putative carrier males contain a total of 15 female progeny over age 20. Of these, six have manifested breast cancer and five have had ovarian cancer. These results underscore the need for physicians to be cognizant of both males and females as potential transmitters of cancer in this familial tumor association.

Original languageEnglish
Pages (from-to)1543-1549
Number of pages7
JournalCancer
Volume41
Issue number4
DOIs
StatePublished - 1978

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Ovarian Neoplasms
Breast Neoplasms
Pedigree
Nuclear Family
Mothers
Neoplasms
Neoplasm Genes
Medical Genetics
Fathers
Cluster Analysis
Physicians
Population

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Lynch, H. T., Harris, R. E., Guirgis, H. A., Maloney, K., Carmody, L. L., & Lynch, J. F. (1978). Familial association of breast/ovarian carcinoma. Cancer, 41(4), 1543-1549. https://doi.org/10.1002/1097-0142(197804)41:4<1543::AID-CNCR2820410444>3.0.CO;2-Y

Familial association of breast/ovarian carcinoma. / Lynch, Henry T.; Harris, R. E.; Guirgis, H. A.; Maloney, K.; Carmody, L. L.; Lynch, J. F.

In: Cancer, Vol. 41, No. 4, 1978, p. 1543-1549.

Research output: Contribution to journalArticle

Lynch, HT, Harris, RE, Guirgis, HA, Maloney, K, Carmody, LL & Lynch, JF 1978, 'Familial association of breast/ovarian carcinoma', Cancer, vol. 41, no. 4, pp. 1543-1549. https://doi.org/10.1002/1097-0142(197804)41:4<1543::AID-CNCR2820410444>3.0.CO;2-Y
Lynch, Henry T. ; Harris, R. E. ; Guirgis, H. A. ; Maloney, K. ; Carmody, L. L. ; Lynch, J. F. / Familial association of breast/ovarian carcinoma. In: Cancer. 1978 ; Vol. 41, No. 4. pp. 1543-1549.
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