Abstract
Genetic analysis was performed on four kindreds with clinical and pathological verification of the FAMMM syndrome. There were 80 affected or at risk members in these families. A segregation ratio of 0.47 was observed, which is consistent with an autosomal dominant mode of inheritance. Three obligate gene carriers who lacked any FAMMM phenotypic manifestations were observed and the rate of penetrance for the FAMMM gene was calculated to be 0.93. Cancer at all anatomical sites (exclusive of cutaneous malignant melanoma and intraocular malignant melanoma) showed a five-fold increase (p
| Original language | English |
|---|---|
| Pages (from-to) | 342-344 |
| Number of pages | 3 |
| Journal | Journal of Medical Genetics |
| Volume | 20 |
| Issue number | 5 |
| State | Published - 1983 |
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All Science Journal Classification (ASJC) codes
- Genetics
- Genetics(clinical)
Cite this
Familial atypical multiple mole-melanoma (FAMMM) syndrome : Segregation analysis. / Lynch, Henry T.; Fusaro, R. M.; Kimberling, W. J.; Lynch, J. F.; Danes, B. S.
In: Journal of Medical Genetics, Vol. 20, No. 5, 1983, p. 342-344.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Familial atypical multiple mole-melanoma (FAMMM) syndrome
T2 - Segregation analysis
AU - Lynch, Henry T.
AU - Fusaro, R. M.
AU - Kimberling, W. J.
AU - Lynch, J. F.
AU - Danes, B. S.
PY - 1983
Y1 - 1983
N2 - Genetic analysis was performed on four kindreds with clinical and pathological verification of the FAMMM syndrome. There were 80 affected or at risk members in these families. A segregation ratio of 0.47 was observed, which is consistent with an autosomal dominant mode of inheritance. Three obligate gene carriers who lacked any FAMMM phenotypic manifestations were observed and the rate of penetrance for the FAMMM gene was calculated to be 0.93. Cancer at all anatomical sites (exclusive of cutaneous malignant melanoma and intraocular malignant melanoma) showed a five-fold increase (p
AB - Genetic analysis was performed on four kindreds with clinical and pathological verification of the FAMMM syndrome. There were 80 affected or at risk members in these families. A segregation ratio of 0.47 was observed, which is consistent with an autosomal dominant mode of inheritance. Three obligate gene carriers who lacked any FAMMM phenotypic manifestations were observed and the rate of penetrance for the FAMMM gene was calculated to be 0.93. Cancer at all anatomical sites (exclusive of cutaneous malignant melanoma and intraocular malignant melanoma) showed a five-fold increase (p
UR - http://www.scopus.com/inward/record.url?scp=0020557521&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020557521&partnerID=8YFLogxK
M3 - Article
VL - 20
SP - 342
EP - 344
JO - Journal of Medical Genetics
JF - Journal of Medical Genetics
SN - 0022-2593
IS - 5
ER -