Abstract
Genetic analysis was performed on four kindreds with clinical and pathological verification of the FAMMM syndrome. There were 80 affected or at risk members in these families. A segregation ratio of 0.47 was observed, which is consistent with an autosomal dominant mode of inheritance. Three obligate gene carriers who lacked any FAMMM phenotypic manifestations were observed and the rate of penetrance for the FAMMM gene was calculated to be 0.93. Cancer at all anatomical sites (exclusive of cutaneous malignant melanoma and intraocular malignant melanoma) showed a five-fold increase (p
| Original language | English |
|---|---|
| Pages (from-to) | 342-344 |
| Number of pages | 3 |
| Journal | Journal of Medical Genetics |
| Volume | 20 |
| Issue number | 5 |
| Publication status | Published - 1983 |
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All Science Journal Classification (ASJC) codes
- Genetics
- Genetics(clinical)
Cite this
Lynch, H. T., Fusaro, R. M., Kimberling, W. J., Lynch, J. F., & Danes, B. S. (1983). Familial atypical multiple mole-melanoma (FAMMM) syndrome: Segregation analysis. Journal of Medical Genetics, 20(5), 342-344.