Familial atypical multiple mole-melanoma syndrome

H. T. Lynch, B. C. Frichot, J. F. Lynch

Research output: Contribution to journalArticlepeer-review

263 Scopus citations


A family is described showing concordance for malignant melanoma and a cutaneous phenotype characterised by multiple large moles of variable size and colour (reddish-brown to bright red) with pigmentary leakage. Transmission of the cutaneous phenotype in the subject family, and in several others currently under investigation, shows an inheritance pattern consistent with a simple autosomal dominant factor. This cutaneous phenotype signifying melanoma risk may now be added to an increasing body of knowledge dealing with cancer-related genodermatoses.

Original languageEnglish (US)
Pages (from-to)352-356
Number of pages5
JournalJournal of Medical Genetics
Issue number5
StatePublished - 1978
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)


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