Familial breast-ovarian cancer locus on chromosome 17q12-q23

S. A. Narod, J. Feunteun, Henry T. Lynch, P. Watson, T. Conway, J. Lynch, G. M. Lenoir

Research output: Contribution to journalArticle

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Abstract

Familial breast cancer has been linked to the D17S74 locus on chromosome 17q. To confirm this finding and to investigate whether ovarian cancer is also linked to this locus, five large families with a hereditary predisposition to cancer of the breast and ovary were investigated. Three families were positive for linkage. For the largest family the lod score was 2.72. These findings suggest that the chromosomal region 17q12-q23, previously shown to contain a gene for early-onset breast cancer, is also associated with a proportion of hereditary ovarian cancers.

Original languageEnglish (US)
Pages (from-to)82-83
Number of pages2
JournalLancet
Volume338
Issue number8759
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

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Ovarian Neoplasms
Chromosomes
Breast Neoplasms
Lod Score
Genes
Familial Breast Cancer

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Narod, S. A., Feunteun, J., Lynch, H. T., Watson, P., Conway, T., Lynch, J., & Lenoir, G. M. (1991). Familial breast-ovarian cancer locus on chromosome 17q12-q23. Lancet, 338(8759), 82-83. https://doi.org/10.1016/0140-6736(91)90076-2

Familial breast-ovarian cancer locus on chromosome 17q12-q23. / Narod, S. A.; Feunteun, J.; Lynch, Henry T.; Watson, P.; Conway, T.; Lynch, J.; Lenoir, G. M.

In: Lancet, Vol. 338, No. 8759, 01.01.1991, p. 82-83.

Research output: Contribution to journalArticle

Narod, SA, Feunteun, J, Lynch, HT, Watson, P, Conway, T, Lynch, J & Lenoir, GM 1991, 'Familial breast-ovarian cancer locus on chromosome 17q12-q23', Lancet, vol. 338, no. 8759, pp. 82-83. https://doi.org/10.1016/0140-6736(91)90076-2
Narod SA, Feunteun J, Lynch HT, Watson P, Conway T, Lynch J et al. Familial breast-ovarian cancer locus on chromosome 17q12-q23. Lancet. 1991 Jan 1;338(8759):82-83. https://doi.org/10.1016/0140-6736(91)90076-2
Narod, S. A. ; Feunteun, J. ; Lynch, Henry T. ; Watson, P. ; Conway, T. ; Lynch, J. ; Lenoir, G. M. / Familial breast-ovarian cancer locus on chromosome 17q12-q23. In: Lancet. 1991 ; Vol. 338, No. 8759. pp. 82-83.
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