Abstract
Family N, a family with an extraordinarily high frequency of adenocarcinoma in specific branches of the family, consistent with the cancer family syndrome, has been extensively investigated. During an eight-year period, cancer was found to have occurred in 21 additional family members. Six of the individuals in whom cancer had been previously ascertained, 28% of those who developed cancer during this eight-year period, were found to have acquired additional primary cancers. One of them had four separate primary cancers, and another one had three. Pedigree analyses have shown repeatedly that individuals from particular lineages tend to develop cancers of specific anatomic sites. It is suggested that gene-transmitted constitutional differences may interact with nongenetic factors, possibly oncogenic viruses, to produce cancer in such family members who are at relatively high risk. Cancer control programs utilizing established familial risk information should be developed for better management of these familial cancer problems.
| Original language | English |
|---|---|
| Pages (from-to) | 931-938 |
| Number of pages | 8 |
| Journal | Archives of Internal Medicine |
| Volume | 134 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1974 |
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All Science Journal Classification (ASJC) codes
- Internal Medicine
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Familial Cancer Prevalence Spanning Eight Years : Family N. / Lynch, Henry T.
In: Archives of Internal Medicine, Vol. 134, No. 5, 1974, p. 931-938.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Familial Cancer Prevalence Spanning Eight Years
T2 - Family N
AU - Lynch, Henry T.
PY - 1974
Y1 - 1974
N2 - Family N, a family with an extraordinarily high frequency of adenocarcinoma in specific branches of the family, consistent with the cancer family syndrome, has been extensively investigated. During an eight-year period, cancer was found to have occurred in 21 additional family members. Six of the individuals in whom cancer had been previously ascertained, 28% of those who developed cancer during this eight-year period, were found to have acquired additional primary cancers. One of them had four separate primary cancers, and another one had three. Pedigree analyses have shown repeatedly that individuals from particular lineages tend to develop cancers of specific anatomic sites. It is suggested that gene-transmitted constitutional differences may interact with nongenetic factors, possibly oncogenic viruses, to produce cancer in such family members who are at relatively high risk. Cancer control programs utilizing established familial risk information should be developed for better management of these familial cancer problems.
AB - Family N, a family with an extraordinarily high frequency of adenocarcinoma in specific branches of the family, consistent with the cancer family syndrome, has been extensively investigated. During an eight-year period, cancer was found to have occurred in 21 additional family members. Six of the individuals in whom cancer had been previously ascertained, 28% of those who developed cancer during this eight-year period, were found to have acquired additional primary cancers. One of them had four separate primary cancers, and another one had three. Pedigree analyses have shown repeatedly that individuals from particular lineages tend to develop cancers of specific anatomic sites. It is suggested that gene-transmitted constitutional differences may interact with nongenetic factors, possibly oncogenic viruses, to produce cancer in such family members who are at relatively high risk. Cancer control programs utilizing established familial risk information should be developed for better management of these familial cancer problems.
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UR - http://www.scopus.com/inward/citedby.url?scp=0016352650&partnerID=8YFLogxK
U2 - 10.1001/archinte.1974.00320230141026
DO - 10.1001/archinte.1974.00320230141026
M3 - Article
VL - 134
SP - 931
EP - 938
JO - JAMA Internal Medicine
JF - JAMA Internal Medicine
SN - 2168-6106
IS - 5
ER -