Familial cancer syndromes

a survey

Henry T. Lynch, H. A. Guirgis, P. M. Lynch, J. F. Lynch, R. E. Harris

Research output: Contribution to journalReview article

43 Citations (Scopus)

Abstract

Several pre-malignant diseases are known to have a genetic etiology. This study focuses attention upon precancerous disorders wherein the mode of inheritance is either well established or wherein it remains unclear even though familial aggregation of the particular diseases has been amply documented. These conditions will be discussed as useful for systematic investigations of the host etiologic component in carcinogenesis. This survey of hereditary pre-cancerous syndromes includes multiple polyposis of the coli, the multiple mucosal neuroma syndrome, the Cancer Family Syndrome, Sipple's syndrome, Von Recklinghausen's neurofibromatosus, the multiple nevoid basal cell carcinoma syndrome, tuberous sclerosis, familial cutaneous malignant melanoma, and carcinoma of the breast. The heterogeneous character of many forms of familial cancer is emphasized. Familial breast cancer associations clearly show such hetrogeneity, as do colon cancer syndromes. Certain of these precancerous states are characterized by phenotypes which are clinically apparent, polyposis coli being the classic example. Others, such as Sipple's syndrome are amenable to routine screening for biochemical markers. The bulk of putative genetic cancer-predisposing problems require further basic investigation of modes of inheritance. Cancer control may be enhanced through communication of useful genetic and diagnostic information to primary care physicians. Referral of cancer clusters of possible genetic etiology from clinicians to human geneticists facilitates the necessary basic research.

Original languageEnglish
Pages (from-to)1867-1881
Number of pages15
JournalCancer
Volume39
Issue number4 Sup
StatePublished - 1977

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Multiple Endocrine Neoplasia Type 2a
Adenomatous Polyposis Coli
Neoplasms
Multiple Endocrine Neoplasia Type 2b
Basal Cell Nevus Syndrome
Tuberous Sclerosis
Primary Care Physicians
Colonic Neoplasms
Carcinogenesis
Referral and Consultation
Biomarkers
Communication
Surveys and Questionnaires
Breast Neoplasms
Phenotype
Research
Multiple basal cell carcinoma
Familial Breast Cancer
Cutaneous Malignant Melanoma

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Lynch, H. T., Guirgis, H. A., Lynch, P. M., Lynch, J. F., & Harris, R. E. (1977). Familial cancer syndromes: a survey. Cancer, 39(4 Sup), 1867-1881.

Familial cancer syndromes : a survey. / Lynch, Henry T.; Guirgis, H. A.; Lynch, P. M.; Lynch, J. F.; Harris, R. E.

In: Cancer, Vol. 39, No. 4 Sup, 1977, p. 1867-1881.

Research output: Contribution to journalReview article

Lynch, HT, Guirgis, HA, Lynch, PM, Lynch, JF & Harris, RE 1977, 'Familial cancer syndromes: a survey', Cancer, vol. 39, no. 4 Sup, pp. 1867-1881.
Lynch HT, Guirgis HA, Lynch PM, Lynch JF, Harris RE. Familial cancer syndromes: a survey. Cancer. 1977;39(4 Sup):1867-1881.
Lynch, Henry T. ; Guirgis, H. A. ; Lynch, P. M. ; Lynch, J. F. ; Harris, R. E. / Familial cancer syndromes : a survey. In: Cancer. 1977 ; Vol. 39, No. 4 Sup. pp. 1867-1881.
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