Familial Excess of Cancer of the Ovary and Other Anatomic Sites

Henry T. Lynch, Lynn Black, Jane F. Lynch, William Albano, James Recabaren, Robert Pierson

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

In a family with a high incidence of cancer, the proband manifested early-onset colon cancer at age 39 years. His mother, her twin sister, and their daughters had ovarian carcinoma. In the proband's sibship, six of eight had cancer of differing anatomic sites. The susceptibility to ovarian carcinoma appeared to have been transmitted through the men; one was cancer free while two had cancer. Thus, eight close relatives had ovarian carcinoma. Examinations of 51 blood relatives failed to show cutaneous stigmata or congenital abnormalities of known hereditary cancer or precancer syndromes. (JAMA 1981;245:261-264).

Original languageEnglish (US)
Pages (from-to)261-264
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Volume245
Issue number3
DOIs
StatePublished - Jan 16 1981

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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