Abstract
In a family with a high incidence of cancer, the proband manifested early-onset colon cancer at age 39 years. His mother, her twin sister, and their daughters had ovarian carcinoma. In the proband's sibship, six of eight had cancer of differing anatomic sites. The susceptibility to ovarian carcinoma appeared to have been transmitted through the men; one was cancer free while two had cancer. Thus, eight close relatives had ovarian carcinoma. Examinations of 51 blood relatives failed to show cutaneous stigmata or congenital abnormalities of known hereditary cancer or precancer syndromes. (JAMA 1981;245:261-264).
| Original language | English |
|---|---|
| Pages (from-to) | 261-264 |
| Number of pages | 4 |
| Journal | JAMA - Journal of the American Medical Association |
| Volume | 245 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 16 1981 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
Cite this
Familial Excess of Cancer of the Ovary and Other Anatomic Sites. / Lynch, Henry T.; Black, Lynn; Lynch, Jane F.; Albano, William; Recabaren, James; Pierson, Robert.
In: JAMA - Journal of the American Medical Association, Vol. 245, No. 3, 16.01.1981, p. 261-264.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Familial Excess of Cancer of the Ovary and Other Anatomic Sites
AU - Lynch, Henry T.
AU - Black, Lynn
AU - Lynch, Jane F.
AU - Albano, William
AU - Recabaren, James
AU - Pierson, Robert
PY - 1981/1/16
Y1 - 1981/1/16
N2 - In a family with a high incidence of cancer, the proband manifested early-onset colon cancer at age 39 years. His mother, her twin sister, and their daughters had ovarian carcinoma. In the proband's sibship, six of eight had cancer of differing anatomic sites. The susceptibility to ovarian carcinoma appeared to have been transmitted through the men; one was cancer free while two had cancer. Thus, eight close relatives had ovarian carcinoma. Examinations of 51 blood relatives failed to show cutaneous stigmata or congenital abnormalities of known hereditary cancer or precancer syndromes. (JAMA 1981;245:261-264).
AB - In a family with a high incidence of cancer, the proband manifested early-onset colon cancer at age 39 years. His mother, her twin sister, and their daughters had ovarian carcinoma. In the proband's sibship, six of eight had cancer of differing anatomic sites. The susceptibility to ovarian carcinoma appeared to have been transmitted through the men; one was cancer free while two had cancer. Thus, eight close relatives had ovarian carcinoma. Examinations of 51 blood relatives failed to show cutaneous stigmata or congenital abnormalities of known hereditary cancer or precancer syndromes. (JAMA 1981;245:261-264).
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UR - http://www.scopus.com/inward/citedby.url?scp=84944660641&partnerID=8YFLogxK
U2 - 10.1001/jama.1981.03310280037025
DO - 10.1001/jama.1981.03310280037025
M3 - Article
VL - 245
SP - 261
EP - 264
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
SN - 0002-9955
IS - 3
ER -