Familial Excess of Cancer of the Ovary and Other Anatomic Sites

Henry T. Lynch; Lynn Black; Jane F. Lynch; William Albano; James Recabaren; Robert Pierson

doi:10.1001/jama.1981.03310280037025

Familial Excess of Cancer of the Ovary and Other Anatomic Sites

Henry T. Lynch, Lynn Black, Jane F. Lynch, William Albano, James Recabaren, Robert Pierson

Department of Preventive Medicine

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

In a family with a high incidence of cancer, the proband manifested early-onset colon cancer at age 39 years. His mother, her twin sister, and their daughters had ovarian carcinoma. In the proband's sibship, six of eight had cancer of differing anatomic sites. The susceptibility to ovarian carcinoma appeared to have been transmitted through the men; one was cancer free while two had cancer. Thus, eight close relatives had ovarian carcinoma. Examinations of 51 blood relatives failed to show cutaneous stigmata or congenital abnormalities of known hereditary cancer or precancer syndromes. (JAMA 1981;245:261-264).

Original language	English (US)
Pages (from-to)	261-264
Number of pages	4
Journal	JAMA: The Journal of the American Medical Association
Volume	245
Issue number	3
DOIs	https://doi.org/10.1001/jama.1981.03310280037025
State	Published - Jan 16 1981

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.1001/jama.1981.03310280037025

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title = "Familial Excess of Cancer of the Ovary and Other Anatomic Sites",

abstract = "In a family with a high incidence of cancer, the proband manifested early-onset colon cancer at age 39 years. His mother, her twin sister, and their daughters had ovarian carcinoma. In the proband's sibship, six of eight had cancer of differing anatomic sites. The susceptibility to ovarian carcinoma appeared to have been transmitted through the men; one was cancer free while two had cancer. Thus, eight close relatives had ovarian carcinoma. Examinations of 51 blood relatives failed to show cutaneous stigmata or congenital abnormalities of known hereditary cancer or precancer syndromes. (JAMA 1981;245:261-264).",

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T1 - Familial Excess of Cancer of the Ovary and Other Anatomic Sites

AU - Lynch, Henry T.

AU - Black, Lynn

AU - Lynch, Jane F.

AU - Albano, William

AU - Recabaren, James

AU - Pierson, Robert

PY - 1981/1/16

Y1 - 1981/1/16

N2 - In a family with a high incidence of cancer, the proband manifested early-onset colon cancer at age 39 years. His mother, her twin sister, and their daughters had ovarian carcinoma. In the proband's sibship, six of eight had cancer of differing anatomic sites. The susceptibility to ovarian carcinoma appeared to have been transmitted through the men; one was cancer free while two had cancer. Thus, eight close relatives had ovarian carcinoma. Examinations of 51 blood relatives failed to show cutaneous stigmata or congenital abnormalities of known hereditary cancer or precancer syndromes. (JAMA 1981;245:261-264).

AB - In a family with a high incidence of cancer, the proband manifested early-onset colon cancer at age 39 years. His mother, her twin sister, and their daughters had ovarian carcinoma. In the proband's sibship, six of eight had cancer of differing anatomic sites. The susceptibility to ovarian carcinoma appeared to have been transmitted through the men; one was cancer free while two had cancer. Thus, eight close relatives had ovarian carcinoma. Examinations of 51 blood relatives failed to show cutaneous stigmata or congenital abnormalities of known hereditary cancer or precancer syndromes. (JAMA 1981;245:261-264).

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