Familial Excess of Cancer of the Ovary and Other Anatomic Sites

Henry T. Lynch; Lynn Black; Jane F. Lynch; William Albano; James Recabaren; Robert Pierson

doi:10.1001/jama.1981.03310280037025

Familial Excess of Cancer of the Ovary and Other Anatomic Sites

Henry T. Lynch, Lynn Black, Jane F. Lynch, William Albano, James Recabaren, Robert Pierson

Department of Preventive Medicine

Research output: Contribution to journal › Article

35 Scopus citations

Abstract

In a family with a high incidence of cancer, the proband manifested early-onset colon cancer at age 39 years. His mother, her twin sister, and their daughters had ovarian carcinoma. In the proband's sibship, six of eight had cancer of differing anatomic sites. The susceptibility to ovarian carcinoma appeared to have been transmitted through the men; one was cancer free while two had cancer. Thus, eight close relatives had ovarian carcinoma. Examinations of 51 blood relatives failed to show cutaneous stigmata or congenital abnormalities of known hereditary cancer or precancer syndromes. (JAMA 1981;245:261-264).

Original language	English
Pages (from-to)	261-264
Number of pages	4
Journal	JAMA - Journal of the American Medical Association
Volume	245
Issue number	3
DOIs	https://doi.org/10.1001/jama.1981.03310280037025
Publication status	Published - Jan 16 1981

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All Science Journal Classification (ASJC) codes

Medicine(all)

Cite this

Lynch, H. T., Black, L., Lynch, J. F., Albano, W., Recabaren, J., & Pierson, R. (1981). Familial Excess of Cancer of the Ovary and Other Anatomic Sites. JAMA - Journal of the American Medical Association, 245(3), 261-264. https://doi.org/10.1001/jama.1981.03310280037025

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10.1001/jama.1981.03310280037025