Familial factors in bladder carcinoma

Henry T. Lynch, M. P. Walzak, R. Fried, A. H. Domina, J. F. Lynch

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Surprinsingly, little is known about host factors in cases of bladder carcinoma. We investigated 2 families prone to transitional cell carcinoma of the bladder. A high degree of pathology verification of cancer of all anatomic sites and a meticulous recording of genealogy, associated diseases and environmental exposures, when known, have allowed a more cogent appraisal of cancer etiology. It is reasonable to assume that members of the subject families may be more susceptible to variable carcinogenic exposures, a concept that is in accord with a genetic-environmental interaction hypothesis for cancer etiology. In addition to increased surveillance of high risk patients for earlier detection of bladder cancer, cancer control measures also should take into consideration preventive programs directed toward the avoidance of known carcinogenic exposures, such as cigarette smoking in high risk relatives of cancer-affected probands. We propose that the etiology of familial bladder cancer may be complex, involving possible other associated malignant neoplasms and/or certain non-neoplastic disorders, in addition to specific carcinogenic exposures. There is a serious need for the detailed reporting of families prone to bladder cancer wherein all of these potentially important associated factors are considered, so that a fuller appraisal of etiology might be achieved.

Original languageEnglish
Pages (from-to)458-461
Number of pages4
JournalJournal of Urology
Volume122
Issue number4
StatePublished - 1979

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Urinary Bladder
Carcinoma
Urinary Bladder Neoplasms
Neoplasms
Preventive Health Services
Genealogy and Heraldry
Transitional Cell Carcinoma
Environmental Exposure
Early Detection of Cancer
Smoking
Pathology

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Lynch, H. T., Walzak, M. P., Fried, R., Domina, A. H., & Lynch, J. F. (1979). Familial factors in bladder carcinoma. Journal of Urology, 122(4), 458-461.

Familial factors in bladder carcinoma. / Lynch, Henry T.; Walzak, M. P.; Fried, R.; Domina, A. H.; Lynch, J. F.

In: Journal of Urology, Vol. 122, No. 4, 1979, p. 458-461.

Research output: Contribution to journalArticle

Lynch, HT, Walzak, MP, Fried, R, Domina, AH & Lynch, JF 1979, 'Familial factors in bladder carcinoma', Journal of Urology, vol. 122, no. 4, pp. 458-461.
Lynch HT, Walzak MP, Fried R, Domina AH, Lynch JF. Familial factors in bladder carcinoma. Journal of Urology. 1979;122(4):458-461.
Lynch, Henry T. ; Walzak, M. P. ; Fried, R. ; Domina, A. H. ; Lynch, J. F. / Familial factors in bladder carcinoma. In: Journal of Urology. 1979 ; Vol. 122, No. 4. pp. 458-461.
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