Familial Hodgkin's disease and associated cancer. A clinical pathologic study

Henry T. Lynch, V. A. Saldivar, H. A. Guirgis, P. I. Terasaki, W. A. Bardawil, R. E. Harris, J. F. Lynch, R. Thomas

Research output: Contribution to journalArticle

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Abstract

The etiology of Hodgkin's disease is complex, as is evident in studies suggesting the importance of horizontal transmission, occupational factors, racial and ethnic background, and familial, genetic factors, or both, including HL A associations. The present study is of a remarkable kindred in which Hodgkin's disease was histologically verified in 2 sibships involving second cousins related through maternal great grandparents. Cancer of the lung, breast, endometrium, ovary, pancreas, and brain, as well as leukemia and Wilms' tumor, occurred in first and second degree relatives of the Hodgkin's patients. HL A haplotypes in patients with Hodgkin's disease in this family showed HL AB5 or HL ABW35, an association confirmed in other reports. The findings of associated malignant neoplasms in familial Hodgkin's disease, here and elsewhere in the literature, suggest that in the quest for etiology of Hodgkin's disease one must view the disorder eclectically, with a painstaking search for multiple etiologies, genetic and environmental.

Original languageEnglish
Pages (from-to)2033-2041
Number of pages9
JournalCancer
Volume38
Issue number5
StatePublished - 1976
Externally publishedYes

Fingerprint

Hodgkin Disease
Neoplasms
Wilms Tumor
Endometrium
Haplotypes
Clinical Studies
Pancreas
Ovary
Lung Neoplasms
Leukemia
Mothers
Breast Neoplasms
Brain

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Lynch, H. T., Saldivar, V. A., Guirgis, H. A., Terasaki, P. I., Bardawil, W. A., Harris, R. E., ... Thomas, R. (1976). Familial Hodgkin's disease and associated cancer. A clinical pathologic study. Cancer, 38(5), 2033-2041.

Familial Hodgkin's disease and associated cancer. A clinical pathologic study. / Lynch, Henry T.; Saldivar, V. A.; Guirgis, H. A.; Terasaki, P. I.; Bardawil, W. A.; Harris, R. E.; Lynch, J. F.; Thomas, R.

In: Cancer, Vol. 38, No. 5, 1976, p. 2033-2041.

Research output: Contribution to journalArticle

Lynch, HT, Saldivar, VA, Guirgis, HA, Terasaki, PI, Bardawil, WA, Harris, RE, Lynch, JF & Thomas, R 1976, 'Familial Hodgkin's disease and associated cancer. A clinical pathologic study', Cancer, vol. 38, no. 5, pp. 2033-2041.
Lynch HT, Saldivar VA, Guirgis HA, Terasaki PI, Bardawil WA, Harris RE et al. Familial Hodgkin's disease and associated cancer. A clinical pathologic study. Cancer. 1976;38(5):2033-2041.
Lynch, Henry T. ; Saldivar, V. A. ; Guirgis, H. A. ; Terasaki, P. I. ; Bardawil, W. A. ; Harris, R. E. ; Lynch, J. F. ; Thomas, R. / Familial Hodgkin's disease and associated cancer. A clinical pathologic study. In: Cancer. 1976 ; Vol. 38, No. 5. pp. 2033-2041.
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