TY - JOUR
T1 - Familial Hodgkin's disease and associated cancer. A Clinical‐Pathologic Study
AU - Lynch, Henry T.
AU - Saldivar, Victor A.
AU - Guirgis, Hoda A.
AU - Terasaki, Paul I.
AU - Bardawil, Wadi A.
AU - Harris, Randall E.
AU - Lynch, Jane F.
AU - Thomas, Robert
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1976/11
Y1 - 1976/11
N2 - The etiology of Hodgkin's disease is complex, as is evident in studies suggesting the importance of horizontal transmission, occupational factors, racial and ethnic background, and familial, genetic factors, or both, including HL A associations. The present study is of a remarkable kindred in which Hodgkin's disease was histologically verified in 2 sibships involving second cousins related through maternal great grandparents. Cancer of the lung, breast, endometrium, ovary, pancreas, and brain, as well as leukemia and Wilms' tumor, occurred in first and second degree relatives of the Hodgkin's patients. HL A haplotypes in patients with Hodgkin's disease in this family showed HL AB5 or HL ABW35, an association confirmed in other reports. The findings of associated malignant neoplasms in familial Hodgkin's disease, here and elsewhere in the literature, suggest that in the quest for etiology of Hodgkin's disease one must view the disorder eclectically, with a painstaking search for multiple etiologies, genetic and environmental.
AB - The etiology of Hodgkin's disease is complex, as is evident in studies suggesting the importance of horizontal transmission, occupational factors, racial and ethnic background, and familial, genetic factors, or both, including HL A associations. The present study is of a remarkable kindred in which Hodgkin's disease was histologically verified in 2 sibships involving second cousins related through maternal great grandparents. Cancer of the lung, breast, endometrium, ovary, pancreas, and brain, as well as leukemia and Wilms' tumor, occurred in first and second degree relatives of the Hodgkin's patients. HL A haplotypes in patients with Hodgkin's disease in this family showed HL AB5 or HL ABW35, an association confirmed in other reports. The findings of associated malignant neoplasms in familial Hodgkin's disease, here and elsewhere in the literature, suggest that in the quest for etiology of Hodgkin's disease one must view the disorder eclectically, with a painstaking search for multiple etiologies, genetic and environmental.
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U2 - 10.1002/1097-0142(197611)38:5<2033::AID-CNCR2820380528>3.0.CO;2-P
DO - 10.1002/1097-0142(197611)38:5<2033::AID-CNCR2820380528>3.0.CO;2-P
M3 - Article
C2 - 991117
AN - SCOPUS:0017192830
VL - 38
SP - 2033
EP - 2041
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 5
ER -