Familial Hodgkin's disease and associated cancer. A Clinical‐Pathologic Study

Henry T. Lynch, Victor A. Saldivar, Hoda A. Guirgis, Paul I. Terasaki, Wadi A. Bardawil, Randall E. Harris, Jane F. Lynch, Robert Thomas

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The etiology of Hodgkin's disease is complex, as is evident in studies suggesting the importance of horizontal transmission, occupational factors, racial and ethnic background, and familial, genetic factors, or both, including HL A associations. The present study is of a remarkable kindred in which Hodgkin's disease was histologically verified in 2 sibships involving second cousins related through maternal great grandparents. Cancer of the lung, breast, endometrium, ovary, pancreas, and brain, as well as leukemia and Wilms' tumor, occurred in first and second degree relatives of the Hodgkin's patients. HL A haplotypes in patients with Hodgkin's disease in this family showed HL AB5 or HL ABW35, an association confirmed in other reports. The findings of associated malignant neoplasms in familial Hodgkin's disease, here and elsewhere in the literature, suggest that in the quest for etiology of Hodgkin's disease one must view the disorder eclectically, with a painstaking search for multiple etiologies, genetic and environmental.

Original languageEnglish (US)
Pages (from-to)2033-2041
Number of pages9
JournalCancer
Volume38
Issue number5
DOIs
StatePublished - Nov 1976
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Familial Hodgkin's disease and associated cancer. A Clinical‐Pathologic Study'. Together they form a unique fingerprint.

  • Cite this

    Lynch, H. T., Saldivar, V. A., Guirgis, H. A., Terasaki, P. I., Bardawil, W. A., Harris, R. E., Lynch, J. F., & Thomas, R. (1976). Familial Hodgkin's disease and associated cancer. A Clinical‐Pathologic Study. Cancer, 38(5), 2033-2041. https://doi.org/10.1002/1097-0142(197611)38:5<2033::AID-CNCR2820380528>3.0.CO;2-P