Familial ovarian carcinoma. Clinical nuances

Henry T. Lynch; Chhanda Bewtra; Jane F. Lynch

doi:10.1016/0002-9343(86)90411-0

Familial ovarian carcinoma. Clinical nuances

Henry T. Lynch, Chhanda Bewtra, Jane F. Lynch

Department of Preventive Medicine

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Familial ovarian carcinoma has been recognized with increased frequency during the past decade commensurate with physician attention to family history. Putative autosomal dominant inheritance of this heterogeneous problem mandates attention to both paternal and maternal lineages. A family with probable paternal transmission of breast/ovarian carcinoma is presented. One family member had findings consonant with papillary serous adenocarcinoma of ovarian origin, which may have arisen directly from extra-ovarian pelvic mesothelium. These and other clinical nuances of familial ovarian carcinoma are discussed in order to aid physicians in understanding the natural history, surveillance, and management of familial ovarian carcinoma.

Original language	English (US)
Pages (from-to)	1073-1076
Number of pages	4
Journal	The American Journal of Medicine
Volume	81
Issue number	6
DOIs	https://doi.org/10.1016/0002-9343(86)90411-0
State	Published - Dec 1986

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Medicine(all)

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title = "Familial ovarian carcinoma. Clinical nuances",

abstract = "Familial ovarian carcinoma has been recognized with increased frequency during the past decade commensurate with physician attention to family history. Putative autosomal dominant inheritance of this heterogeneous problem mandates attention to both paternal and maternal lineages. A family with probable paternal transmission of breast/ovarian carcinoma is presented. One family member had findings consonant with papillary serous adenocarcinoma of ovarian origin, which may have arisen directly from extra-ovarian pelvic mesothelium. These and other clinical nuances of familial ovarian carcinoma are discussed in order to aid physicians in understanding the natural history, surveillance, and management of familial ovarian carcinoma.",

author = "Lynch, {Henry T.} and Chhanda Bewtra and Lynch, {Jane F.}",

note = "Funding Information: From the Department of Preventive Medicine/ Public Health and the Department of Pathology, Creighton University School of Medicine, and the Hereditary Cancer Institute, Omaha, Nebraska. This study was supported by the Council for Tobacco Research, U.S.A., Inc. (Grant 1297B). Requests for reprints should be addressed to Dr. Henry T. Lynch, Department of Preventive Medicine/Public Health, Creighton University School of Medicine, California at 24th Street, Omaha, Nebraska 68178. Manuscript submitted January 2, 1986, and accepted January 28, 1986.",

year = "1986",

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doi = "10.1016/0002-9343(86)90411-0",

language = "English (US)",

volume = "81",

pages = "1073--1076",

journal = "American Journal of Medicine",

issn = "0002-9343",

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AU - Lynch, Henry T.

AU - Bewtra, Chhanda

AU - Lynch, Jane F.

N1 - Funding Information: From the Department of Preventive Medicine/ Public Health and the Department of Pathology, Creighton University School of Medicine, and the Hereditary Cancer Institute, Omaha, Nebraska. This study was supported by the Council for Tobacco Research, U.S.A., Inc. (Grant 1297B). Requests for reprints should be addressed to Dr. Henry T. Lynch, Department of Preventive Medicine/Public Health, Creighton University School of Medicine, California at 24th Street, Omaha, Nebraska 68178. Manuscript submitted January 2, 1986, and accepted January 28, 1986.

PY - 1986/12

Y1 - 1986/12

N2 - Familial ovarian carcinoma has been recognized with increased frequency during the past decade commensurate with physician attention to family history. Putative autosomal dominant inheritance of this heterogeneous problem mandates attention to both paternal and maternal lineages. A family with probable paternal transmission of breast/ovarian carcinoma is presented. One family member had findings consonant with papillary serous adenocarcinoma of ovarian origin, which may have arisen directly from extra-ovarian pelvic mesothelium. These and other clinical nuances of familial ovarian carcinoma are discussed in order to aid physicians in understanding the natural history, surveillance, and management of familial ovarian carcinoma.

AB - Familial ovarian carcinoma has been recognized with increased frequency during the past decade commensurate with physician attention to family history. Putative autosomal dominant inheritance of this heterogeneous problem mandates attention to both paternal and maternal lineages. A family with probable paternal transmission of breast/ovarian carcinoma is presented. One family member had findings consonant with papillary serous adenocarcinoma of ovarian origin, which may have arisen directly from extra-ovarian pelvic mesothelium. These and other clinical nuances of familial ovarian carcinoma are discussed in order to aid physicians in understanding the natural history, surveillance, and management of familial ovarian carcinoma.

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Familial ovarian carcinoma. Clinical nuances

Abstract

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