Familial pancreatic cancer

Henry T. Lynch, Jane F. Lynch, Stephen J. Lanspa

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Pancreatic cancer's high mortality rate equates closely with its incidence, thereby showing the need for development of biomarkers of its increased risk and a better understanding of its genetics, so that high-risk patients can be better targeted for screening and early potential lifesaving diagnosis. Its phenotypic and genotypic heterogeneity is extensive and requires careful scrutiny of its pattern of cancer associations, such as malignant melanoma associated with pancreatic cancer, in the familial atypical multiple mole melanoma syndrome, due to the CDKN2A germline mutation. This review is designed to depict several of the hereditary pancreatic cancer syndromes with particular attention given to the clinical application of this knowledge into improved control of pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)1861-1883
Number of pages23
JournalCancers
Volume2
Issue number4
DOIs
StatePublished - Dec 2010

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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