Abstract
The etiology of pancreatic cancer remains elusive. Recent attention has been given to host factors, as evidenced by the recognition of familial aggregations of this disease and its association with several hereditary cancer-prone disorders. We have investigated a remarkable family wherein pancreatic cancer has been documented through three generations, including progeny from two of the progenitor’s three marriages. The protocol involved a search for documentation of cancer of all anatomic sites. We did not find any pattern of extrapancreatic cancer occurrences, and age at onset of pancreatic cancer corresponded to population expectations. The recognition of patients at high risk for pancreatic cancer should lead to research into potential environmental factors interacting with host susceptibility for elucidation of etiology and for earlier diagnosis.
| Original language | English |
|---|---|
| Pages (from-to) | 511-515 |
| Number of pages | 5 |
| Journal | Pancreas |
| Volume | 7 |
| Issue number | 5 |
| State | Published - 1992 |
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All Science Journal Classification (ASJC) codes
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Hepatology
- Internal Medicine
- Gastroenterology
Cite this
Familial pancreatic cancer : A family study. / Lynch, Henry T.; Fusaro, Lavonne; Lynch, Jane F.
In: Pancreas, Vol. 7, No. 5, 1992, p. 511-515.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Familial pancreatic cancer
T2 - A family study
AU - Lynch, Henry T.
AU - Fusaro, Lavonne
AU - Lynch, Jane F.
PY - 1992
Y1 - 1992
N2 - The etiology of pancreatic cancer remains elusive. Recent attention has been given to host factors, as evidenced by the recognition of familial aggregations of this disease and its association with several hereditary cancer-prone disorders. We have investigated a remarkable family wherein pancreatic cancer has been documented through three generations, including progeny from two of the progenitor’s three marriages. The protocol involved a search for documentation of cancer of all anatomic sites. We did not find any pattern of extrapancreatic cancer occurrences, and age at onset of pancreatic cancer corresponded to population expectations. The recognition of patients at high risk for pancreatic cancer should lead to research into potential environmental factors interacting with host susceptibility for elucidation of etiology and for earlier diagnosis.
AB - The etiology of pancreatic cancer remains elusive. Recent attention has been given to host factors, as evidenced by the recognition of familial aggregations of this disease and its association with several hereditary cancer-prone disorders. We have investigated a remarkable family wherein pancreatic cancer has been documented through three generations, including progeny from two of the progenitor’s three marriages. The protocol involved a search for documentation of cancer of all anatomic sites. We did not find any pattern of extrapancreatic cancer occurrences, and age at onset of pancreatic cancer corresponded to population expectations. The recognition of patients at high risk for pancreatic cancer should lead to research into potential environmental factors interacting with host susceptibility for elucidation of etiology and for earlier diagnosis.
UR - http://www.scopus.com/inward/record.url?scp=0026784163&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026784163&partnerID=8YFLogxK
M3 - Article
C2 - 1513799
AN - SCOPUS:0026784163
VL - 7
SP - 511
EP - 515
JO - Pancreas
JF - Pancreas
SN - 0885-3177
IS - 5
ER -