Familial pancreatic cancer

A review

Henry T. Lynch, T. Smyrk, S. E. Kern, R. H. Hruban, C. J. Lightdale, S. J. Lemon, J. F. Lynch, L. R. Fusaro, R. M. Fusaro, P. Ghadirian

Research output: Contribution to journalReview article

191 Citations (Scopus)

Abstract

The cause of pancreatic cancer remains elusive. The most consistently identified epidemiological risk factor is cigarette smoking. Genetic factors are known to play a significant role in perhaps 5% of the total pancreatic cancer burden. Recent discoveries in molecular biology, particularly germline mutations in inherited conditions which feature pancreatic cancer as an integral part of the tumor spectrum such as in familial adenomatosis polyposis and hereditary nonpolyposis colorectal cancer, provide powerful incentive to search for other 'cancer genes' in this heterogeneous disease. Early detection of this dreadful disease is crucial because its mortality rate approximates its incidence; the ability to identify highrisk patients on the basis of genetic analysis would significantly enhance the potential for early diagnosis. This review addresses the genetic epidemiology of pancreatic cancer and updates our views on screening, surgery, chemotherapy, and genetic counseling, all of which must be used to gain value from genetic predictability of risk status.

Original languageEnglish
Pages (from-to)251-275
Number of pages25
JournalSeminars in Oncology
Volume23
Issue number2
StatePublished - 1996

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Pancreatic Neoplasms
Early Diagnosis
Hereditary Nonpolyposis Colorectal Neoplasms
Aptitude
Molecular Epidemiology
Germ-Line Mutation
Neoplasm Genes
Genetic Counseling
Motivation
Molecular Biology
Smoking
Drug Therapy
Mortality
Incidence
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Lynch, H. T., Smyrk, T., Kern, S. E., Hruban, R. H., Lightdale, C. J., Lemon, S. J., ... Ghadirian, P. (1996). Familial pancreatic cancer: A review. Seminars in Oncology, 23(2), 251-275.

Familial pancreatic cancer : A review. / Lynch, Henry T.; Smyrk, T.; Kern, S. E.; Hruban, R. H.; Lightdale, C. J.; Lemon, S. J.; Lynch, J. F.; Fusaro, L. R.; Fusaro, R. M.; Ghadirian, P.

In: Seminars in Oncology, Vol. 23, No. 2, 1996, p. 251-275.

Research output: Contribution to journalReview article

Lynch, HT, Smyrk, T, Kern, SE, Hruban, RH, Lightdale, CJ, Lemon, SJ, Lynch, JF, Fusaro, LR, Fusaro, RM & Ghadirian, P 1996, 'Familial pancreatic cancer: A review', Seminars in Oncology, vol. 23, no. 2, pp. 251-275.
Lynch HT, Smyrk T, Kern SE, Hruban RH, Lightdale CJ, Lemon SJ et al. Familial pancreatic cancer: A review. Seminars in Oncology. 1996;23(2):251-275.
Lynch, Henry T. ; Smyrk, T. ; Kern, S. E. ; Hruban, R. H. ; Lightdale, C. J. ; Lemon, S. J. ; Lynch, J. F. ; Fusaro, L. R. ; Fusaro, R. M. ; Ghadirian, P. / Familial pancreatic cancer : A review. In: Seminars in Oncology. 1996 ; Vol. 23, No. 2. pp. 251-275.
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