Familial peritoneal ovarian carcinomatosis

A new clinical entity?

Henry T. Lynch, Chhanda Bewtra, Jane F. Lynch

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A familial form of ovarian carcinoma is now widely recognized. There are at least several ovarian cancer-prone genotypes, consistent with genetic heterogeneity. Prophylactic oophorectomy has been employed for women who were judged to be at 50% risk for this disease by virtue of their position in the pedigree. However, recent evidence has disclosed that a fraction of such patients who underwent prophylactic oophorectomy and who had ovaries which appeared to be histologically normal at surgical resection, subsequently developed intraabdominal carcinomatosis with histologic findings showing the lesions to be indistinguishable from ovarian carcinoma. Given the embryologic derivatives of the ovary, which comprise gonadal ridges composed of mesodermal cells covered by coelomic epithelium, we postulate that patients with hereditary predisposition to ovarian carcinoma harbor the first germinal hit in both the epithelial cells of the ovary as well as their derivatives in the coelomic mesothelium. These patients may then be inordinately susceptible to carcinogenesis from the second (somatic) hit in these same tissues.

Original languageEnglish
Pages (from-to)171-177
Number of pages7
JournalMedical Hypotheses
Volume21
Issue number2
DOIs
StatePublished - 1986

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Carcinoma
Ovary
Ovariectomy
Epithelium
Genetic Heterogeneity
Pedigree
Ovarian Neoplasms
Carcinogenesis
Epithelial Cells
Genotype

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Medicine(all)
  • Drug Discovery

Cite this

Familial peritoneal ovarian carcinomatosis : A new clinical entity? / Lynch, Henry T.; Bewtra, Chhanda; Lynch, Jane F.

In: Medical Hypotheses, Vol. 21, No. 2, 1986, p. 171-177.

Research output: Contribution to journalArticle

Lynch, Henry T. ; Bewtra, Chhanda ; Lynch, Jane F. / Familial peritoneal ovarian carcinomatosis : A new clinical entity?. In: Medical Hypotheses. 1986 ; Vol. 21, No. 2. pp. 171-177.
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