Family studies of malignant melanoma and associated cancer

H. T. Lynch, B. C. Frichot, P. Lynch, J. Lynch, H. A. Gurigis

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


This study comprises five cancer prone families with one or more occurrences of melanoma in context with a variety of other histologic types of cancer, including an excess of multiple primary malignant tumors. The genetic mode of transmission of cancer in each family was consistent with a dominant factor which has seemingly predisposed these patients to a general cancer diathesis. The tumor spectrum included melanoma and cancers of the breast, gastrointestinal tract, lung and lymphoproliferative system. Recently, S 1 an S 2 antigens were noted to occur with melanoma and the same variety of tumors which have occurred in these five families.

Original languageEnglish (US)
Pages (from-to)517-522
Number of pages6
JournalSurgery Gynecology and Obstetrics
Issue number4
StatePublished - Dec 1 1975

All Science Journal Classification (ASJC) codes

  • Surgery
  • Obstetrics and Gynecology


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