Fatal Case of Burkholderia gladioli Pneumonia in a Patient With COVID-19

Sanu Rajendraprasad, Zachary A. Creech, Gia Thinh D. Truong, Toan Nguyen, Mounika Addula, Neil Mendoza, Manasa Velagapudi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Burkholderia gladioli (B gladioli) is a rare, gram-negative rod that was initially regarded as a plant pathogen. However, B gladioli has been reported as the primary pathogen causing pneumonia in organ transplant recipients and in patients with cystic fibrosis. We report a case of bacterial pneumonia caused by B gladioli in a patient hospitalized for coronavirus disease 2019 (COVID-19). Case Report: A 68-year-old male was admitted for acute hypoxic respiratory failure secondary to COVID-19 pneumonia. He was treated with dexamethasone and convalescent plasma, resulting in improvement in the hypoxemia. However, during the latter part of his inpatient stay, the patient developed pneumonia caused by B gladioli. The isolate of B gladioli was sensitive to meropenem, levofloxacin, and trimethoprim/sulfamethoxazole and intermediate to ceftazidime. He was treated with meropenem and levofloxacin. Despite treatment, the patient developed acute respiratory distress syndrome with multiorgan failure, suffered cardiac arrest, and died. Conclusion: To the best of our knowledge, this case is the first report of B gladioli coinfection in a patient hospitalized for COVID-19 and provides insight into the possible detrimental outcome of B gladioli and COVID-19 coinfection.

Original languageEnglish (US)
Pages (from-to)349-352
Number of pages4
JournalOchsner Journal
Volume22
Issue number4
DOIs
StatePublished - Dec 2022

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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