Fibronectin levels in plasma after platelet-activating factor inhalation

Makoto Nabe; Hidefumi Miyagawa; Russell J. Hopp; Devendra K. Agrawal; Againdra K. Bewtra; Robert G. Townley

doi:10.1159/000235100

Fibronectin levels in plasma after platelet-activating factor inhalation

Makoto Nabe, Hidefumi Miyagawa, Russell J. Hopp, Devendra K. Agrawal, Againdra K. Bewtra, Robert G. Townley

Department of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We evaluated fibronectin levels in plasma and blood leukocyte counts after platelet-activating fac-tor-acether (PAF) inhalation to examine whether PAF may cause pulmonary vascular injury. PAF inhalation challenges were performed on 5 normal subjects and 5 atopic asthmatics. Fibronectin levels in plasma were significantly increased at 5 min (342.5 ± 36.9 ug/ml) after PAF challenge as compared with the baseline values of 277.1 ±33.0 ug/ml (p<0.024). Total white blood cell and neutrophil counts were significantly decreased 5 min after PAF inhalation (WBC from 5, 360 ±460 to 4, 260 ±380/mm³ p<0.028; neutrophils from 3, 113 ±441 to 2, 214 ± 344/mm³, p<0.043). Our study shows that plasma fibronectin levels transiently increase and that peripheral total WBC counts decrease after PAF inhalation. Elevated fibronectin levels may provide evidence of pulmonary vascular injury due to neutrophils which might be primed and recruited to pulmonary circulation by PAF.

Original language	English (US)
Pages (from-to)	113-117
Number of pages	5
Journal	International Archives of Allergy and Immunology
Volume	91
Issue number	2
DOIs	https://doi.org/10.1159/000235100
State	Published - Jan 1 1990

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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title = "Fibronectin levels in plasma after platelet-activating factor inhalation",

abstract = "We evaluated fibronectin levels in plasma and blood leukocyte counts after platelet-activating fac-tor-acether (PAF) inhalation to examine whether PAF may cause pulmonary vascular injury. PAF inhalation challenges were performed on 5 normal subjects and 5 atopic asthmatics. Fibronectin levels in plasma were significantly increased at 5 min (342.5 ± 36.9 ug/ml) after PAF challenge as compared with the baseline values of 277.1 ±33.0 ug/ml (p<0.024). Total white blood cell and neutrophil counts were significantly decreased 5 min after PAF inhalation (WBC from 5, 360 ±460 to 4, 260 ±380/mm3 p<0.028; neutrophils from 3, 113 ±441 to 2, 214 ± 344/mm3, p<0.043). Our study shows that plasma fibronectin levels transiently increase and that peripheral total WBC counts decrease after PAF inhalation. Elevated fibronectin levels may provide evidence of pulmonary vascular injury due to neutrophils which might be primed and recruited to pulmonary circulation by PAF.",

author = "Makoto Nabe and Hidefumi Miyagawa and Hopp, {Russell J.} and Agrawal, {Devendra K.} and Bewtra, {Againdra K.} and Townley, {Robert G.}",

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doi = "10.1159/000235100",

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AU - Nabe, Makoto

AU - Miyagawa, Hidefumi

AU - Hopp, Russell J.

AU - Agrawal, Devendra K.

AU - Bewtra, Againdra K.

AU - Townley, Robert G.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - We evaluated fibronectin levels in plasma and blood leukocyte counts after platelet-activating fac-tor-acether (PAF) inhalation to examine whether PAF may cause pulmonary vascular injury. PAF inhalation challenges were performed on 5 normal subjects and 5 atopic asthmatics. Fibronectin levels in plasma were significantly increased at 5 min (342.5 ± 36.9 ug/ml) after PAF challenge as compared with the baseline values of 277.1 ±33.0 ug/ml (p<0.024). Total white blood cell and neutrophil counts were significantly decreased 5 min after PAF inhalation (WBC from 5, 360 ±460 to 4, 260 ±380/mm3 p<0.028; neutrophils from 3, 113 ±441 to 2, 214 ± 344/mm3, p<0.043). Our study shows that plasma fibronectin levels transiently increase and that peripheral total WBC counts decrease after PAF inhalation. Elevated fibronectin levels may provide evidence of pulmonary vascular injury due to neutrophils which might be primed and recruited to pulmonary circulation by PAF.

AB - We evaluated fibronectin levels in plasma and blood leukocyte counts after platelet-activating fac-tor-acether (PAF) inhalation to examine whether PAF may cause pulmonary vascular injury. PAF inhalation challenges were performed on 5 normal subjects and 5 atopic asthmatics. Fibronectin levels in plasma were significantly increased at 5 min (342.5 ± 36.9 ug/ml) after PAF challenge as compared with the baseline values of 277.1 ±33.0 ug/ml (p<0.024). Total white blood cell and neutrophil counts were significantly decreased 5 min after PAF inhalation (WBC from 5, 360 ±460 to 4, 260 ±380/mm3 p<0.028; neutrophils from 3, 113 ±441 to 2, 214 ± 344/mm3, p<0.043). Our study shows that plasma fibronectin levels transiently increase and that peripheral total WBC counts decrease after PAF inhalation. Elevated fibronectin levels may provide evidence of pulmonary vascular injury due to neutrophils which might be primed and recruited to pulmonary circulation by PAF.

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Fibronectin levels in plasma after platelet-activating factor inhalation

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