Abstract
We evaluated fibronectin levels in plasma and blood leukocyte counts after platelet-activating fac-tor-acether (PAF) inhalation to examine whether PAF may cause pulmonary vascular injury. PAF inhalation challenges were performed on 5 normal subjects and 5 atopic asthmatics. Fibronectin levels in plasma were significantly increased at 5 min (342.5 ± 36.9 ug/ml) after PAF challenge as compared with the baseline values of 277.1 ±33.0 ug/ml (p<0.024). Total white blood cell and neutrophil counts were significantly decreased 5 min after PAF inhalation (WBC from 5, 360 ±460 to 4, 260 ±380/mm3 p<0.028; neutrophils from 3, 113 ±441 to 2, 214 ± 344/mm3, p<0.043). Our study shows that plasma fibronectin levels transiently increase and that peripheral total WBC counts decrease after PAF inhalation. Elevated fibronectin levels may provide evidence of pulmonary vascular injury due to neutrophils which might be primed and recruited to pulmonary circulation by PAF.
| Original language | English |
|---|---|
| Pages (from-to) | 113-117 |
| Number of pages | 5 |
| Journal | International Archives of Allergy and Immunology |
| Volume | 91 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1990 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Immunology
- Immunology and Allergy
Cite this
Fibronectin levels in plasma after platelet-activating factor inhalation. / Nabe, Makoto; Miyagawa, Hidefumi; Hopp, Russell J.; Agrawal, Devendra K.; Bewtra, Againdra K.; Townley, Robert G.
In: International Archives of Allergy and Immunology, Vol. 91, No. 2, 1990, p. 113-117.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fibronectin levels in plasma after platelet-activating factor inhalation
AU - Nabe, Makoto
AU - Miyagawa, Hidefumi
AU - Hopp, Russell J.
AU - Agrawal, Devendra K.
AU - Bewtra, Againdra K.
AU - Townley, Robert G.
PY - 1990
Y1 - 1990
N2 - We evaluated fibronectin levels in plasma and blood leukocyte counts after platelet-activating fac-tor-acether (PAF) inhalation to examine whether PAF may cause pulmonary vascular injury. PAF inhalation challenges were performed on 5 normal subjects and 5 atopic asthmatics. Fibronectin levels in plasma were significantly increased at 5 min (342.5 ± 36.9 ug/ml) after PAF challenge as compared with the baseline values of 277.1 ±33.0 ug/ml (p<0.024). Total white blood cell and neutrophil counts were significantly decreased 5 min after PAF inhalation (WBC from 5, 360 ±460 to 4, 260 ±380/mm3 p<0.028; neutrophils from 3, 113 ±441 to 2, 214 ± 344/mm3, p<0.043). Our study shows that plasma fibronectin levels transiently increase and that peripheral total WBC counts decrease after PAF inhalation. Elevated fibronectin levels may provide evidence of pulmonary vascular injury due to neutrophils which might be primed and recruited to pulmonary circulation by PAF.
AB - We evaluated fibronectin levels in plasma and blood leukocyte counts after platelet-activating fac-tor-acether (PAF) inhalation to examine whether PAF may cause pulmonary vascular injury. PAF inhalation challenges were performed on 5 normal subjects and 5 atopic asthmatics. Fibronectin levels in plasma were significantly increased at 5 min (342.5 ± 36.9 ug/ml) after PAF challenge as compared with the baseline values of 277.1 ±33.0 ug/ml (p<0.024). Total white blood cell and neutrophil counts were significantly decreased 5 min after PAF inhalation (WBC from 5, 360 ±460 to 4, 260 ±380/mm3 p<0.028; neutrophils from 3, 113 ±441 to 2, 214 ± 344/mm3, p<0.043). Our study shows that plasma fibronectin levels transiently increase and that peripheral total WBC counts decrease after PAF inhalation. Elevated fibronectin levels may provide evidence of pulmonary vascular injury due to neutrophils which might be primed and recruited to pulmonary circulation by PAF.
UR - http://www.scopus.com/inward/record.url?scp=0025368529&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025368529&partnerID=8YFLogxK
U2 - 10.1159/000235100
DO - 10.1159/000235100
M3 - Article
C2 - 2341190
AN - SCOPUS:0025368529
VL - 91
SP - 113
EP - 117
JO - International Archives of Allergy and Immunology
JF - International Archives of Allergy and Immunology
SN - 1018-2438
IS - 2
ER -