Fibronectin levels in plasma after platelet-activating factor inhalation

Makoto Nabe, Hidefumi Miyagawa, Russell J. Hopp, Devendra K. Agrawal, Againdra K. Bewtra, Robert G. Townley

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We evaluated fibronectin levels in plasma and blood leukocyte counts after platelet-activating fac-tor-acether (PAF) inhalation to examine whether PAF may cause pulmonary vascular injury. PAF inhalation challenges were performed on 5 normal subjects and 5 atopic asthmatics. Fibronectin levels in plasma were significantly increased at 5 min (342.5 ± 36.9 ug/ml) after PAF challenge as compared with the baseline values of 277.1 ±33.0 ug/ml (p<0.024). Total white blood cell and neutrophil counts were significantly decreased 5 min after PAF inhalation (WBC from 5, 360 ±460 to 4, 260 ±380/mm3 p<0.028; neutrophils from 3, 113 ±441 to 2, 214 ± 344/mm3, p<0.043). Our study shows that plasma fibronectin levels transiently increase and that peripheral total WBC counts decrease after PAF inhalation. Elevated fibronectin levels may provide evidence of pulmonary vascular injury due to neutrophils which might be primed and recruited to pulmonary circulation by PAF.

Original languageEnglish
Pages (from-to)113-117
Number of pages5
JournalInternational Archives of Allergy and Immunology
Volume91
Issue number2
DOIs
StatePublished - 1990

Fingerprint

Platelet Activating Factor
Fibronectins
Inhalation
Blood Platelets
Neutrophils
Vascular System Injuries
Lung Injury
Leukocyte Count
Pulmonary Circulation

All Science Journal Classification (ASJC) codes

  • Immunology
  • Immunology and Allergy

Cite this

Fibronectin levels in plasma after platelet-activating factor inhalation. / Nabe, Makoto; Miyagawa, Hidefumi; Hopp, Russell J.; Agrawal, Devendra K.; Bewtra, Againdra K.; Townley, Robert G.

In: International Archives of Allergy and Immunology, Vol. 91, No. 2, 1990, p. 113-117.

Research output: Contribution to journalArticle

Nabe, Makoto ; Miyagawa, Hidefumi ; Hopp, Russell J. ; Agrawal, Devendra K. ; Bewtra, Againdra K. ; Townley, Robert G. / Fibronectin levels in plasma after platelet-activating factor inhalation. In: International Archives of Allergy and Immunology. 1990 ; Vol. 91, No. 2. pp. 113-117.
@article{f8217623d6074d5daa48cadfad2daece,
title = "Fibronectin levels in plasma after platelet-activating factor inhalation",
abstract = "We evaluated fibronectin levels in plasma and blood leukocyte counts after platelet-activating fac-tor-acether (PAF) inhalation to examine whether PAF may cause pulmonary vascular injury. PAF inhalation challenges were performed on 5 normal subjects and 5 atopic asthmatics. Fibronectin levels in plasma were significantly increased at 5 min (342.5 ± 36.9 ug/ml) after PAF challenge as compared with the baseline values of 277.1 ±33.0 ug/ml (p<0.024). Total white blood cell and neutrophil counts were significantly decreased 5 min after PAF inhalation (WBC from 5, 360 ±460 to 4, 260 ±380/mm3 p<0.028; neutrophils from 3, 113 ±441 to 2, 214 ± 344/mm3, p<0.043). Our study shows that plasma fibronectin levels transiently increase and that peripheral total WBC counts decrease after PAF inhalation. Elevated fibronectin levels may provide evidence of pulmonary vascular injury due to neutrophils which might be primed and recruited to pulmonary circulation by PAF.",
author = "Makoto Nabe and Hidefumi Miyagawa and Hopp, {Russell J.} and Agrawal, {Devendra K.} and Bewtra, {Againdra K.} and Townley, {Robert G.}",
year = "1990",
doi = "10.1159/000235100",
language = "English",
volume = "91",
pages = "113--117",
journal = "International Archives of Allergy and Immunology",
issn = "1018-2438",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Fibronectin levels in plasma after platelet-activating factor inhalation

AU - Nabe, Makoto

AU - Miyagawa, Hidefumi

AU - Hopp, Russell J.

AU - Agrawal, Devendra K.

AU - Bewtra, Againdra K.

AU - Townley, Robert G.

PY - 1990

Y1 - 1990

N2 - We evaluated fibronectin levels in plasma and blood leukocyte counts after platelet-activating fac-tor-acether (PAF) inhalation to examine whether PAF may cause pulmonary vascular injury. PAF inhalation challenges were performed on 5 normal subjects and 5 atopic asthmatics. Fibronectin levels in plasma were significantly increased at 5 min (342.5 ± 36.9 ug/ml) after PAF challenge as compared with the baseline values of 277.1 ±33.0 ug/ml (p<0.024). Total white blood cell and neutrophil counts were significantly decreased 5 min after PAF inhalation (WBC from 5, 360 ±460 to 4, 260 ±380/mm3 p<0.028; neutrophils from 3, 113 ±441 to 2, 214 ± 344/mm3, p<0.043). Our study shows that plasma fibronectin levels transiently increase and that peripheral total WBC counts decrease after PAF inhalation. Elevated fibronectin levels may provide evidence of pulmonary vascular injury due to neutrophils which might be primed and recruited to pulmonary circulation by PAF.

AB - We evaluated fibronectin levels in plasma and blood leukocyte counts after platelet-activating fac-tor-acether (PAF) inhalation to examine whether PAF may cause pulmonary vascular injury. PAF inhalation challenges were performed on 5 normal subjects and 5 atopic asthmatics. Fibronectin levels in plasma were significantly increased at 5 min (342.5 ± 36.9 ug/ml) after PAF challenge as compared with the baseline values of 277.1 ±33.0 ug/ml (p<0.024). Total white blood cell and neutrophil counts were significantly decreased 5 min after PAF inhalation (WBC from 5, 360 ±460 to 4, 260 ±380/mm3 p<0.028; neutrophils from 3, 113 ±441 to 2, 214 ± 344/mm3, p<0.043). Our study shows that plasma fibronectin levels transiently increase and that peripheral total WBC counts decrease after PAF inhalation. Elevated fibronectin levels may provide evidence of pulmonary vascular injury due to neutrophils which might be primed and recruited to pulmonary circulation by PAF.

UR - http://www.scopus.com/inward/record.url?scp=0025368529&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025368529&partnerID=8YFLogxK

U2 - 10.1159/000235100

DO - 10.1159/000235100

M3 - Article

C2 - 2341190

AN - SCOPUS:0025368529

VL - 91

SP - 113

EP - 117

JO - International Archives of Allergy and Immunology

JF - International Archives of Allergy and Immunology

SN - 1018-2438

IS - 2

ER -