Fibronectin levels in plasma after platelet-activating factor inhalation

Makoto Nabe, Hidefumi Miyagawa, Russell J. Hopp, Devendra K. Agrawal, Againdra K. Bewtra, Robert G. Townley

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Abstract

We evaluated fibronectin levels in plasma and blood leukocyte counts after platelet-activating fac-tor-acether (PAF) inhalation to examine whether PAF may cause pulmonary vascular injury. PAF inhalation challenges were performed on 5 normal subjects and 5 atopic asthmatics. Fibronectin levels in plasma were significantly increased at 5 min (342.5 ± 36.9 ug/ml) after PAF challenge as compared with the baseline values of 277.1 ±33.0 ug/ml (p<0.024). Total white blood cell and neutrophil counts were significantly decreased 5 min after PAF inhalation (WBC from 5, 360 ±460 to 4, 260 ±380/mm3 p<0.028; neutrophils from 3, 113 ±441 to 2, 214 ± 344/mm3, p<0.043). Our study shows that plasma fibronectin levels transiently increase and that peripheral total WBC counts decrease after PAF inhalation. Elevated fibronectin levels may provide evidence of pulmonary vascular injury due to neutrophils which might be primed and recruited to pulmonary circulation by PAF.

Original languageEnglish
Pages (from-to)113-117
Number of pages5
JournalInternational Archives of Allergy and Immunology
Volume91
Issue number2
DOIs
Publication statusPublished - 1990

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All Science Journal Classification (ASJC) codes

  • Immunology
  • Immunology and Allergy

Cite this

Nabe, M., Miyagawa, H., Hopp, R. J., Agrawal, D. K., Bewtra, A. K., & Townley, R. G. (1990). Fibronectin levels in plasma after platelet-activating factor inhalation. International Archives of Allergy and Immunology, 91(2), 113-117. https://doi.org/10.1159/000235100